Adam Freund
Adam Freund
Founder and CEO, Arda Therapeutics
Verified email at
Cited by
Cited by
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
F Rodier, JP Coppé, CK Patil, WAM Hoeijmakers, DP Muñoz, SR Raza, ...
Nature cell biology 11 (8), 973-979, 2009
Inflammatory networks during cellular senescence: causes and consequences
A Freund, AV Orjalo, PY Desprez, J Campisi
Trends in molecular medicine 16 (5), 238-246, 2010
p38MAPK is a novel DNA damage response‐independent regulator of the senescence‐associated secretory phenotype
A Freund, CK Patil, J Campisi
The EMBO journal 30 (8), 1536-1548, 2011
MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
RM Laberge, YU Sun, AV Orjalo, CK Patil, A Freund, L Zhou, SC Curran, ...
Nature cell biology 17 (8), 1049-1061, 2015
Mitochondrial dysfunction induces senescence with a distinct secretory phenotype
CD Wiley, MC Velarde, P Lecot, SU Liu, EA Sarnoski, A Freund, ...
Cell metabolism 23 (2), 303-314, 2016
Lamin B1 loss is a senescence-associated biomarker
A Freund, RM Laberge, M Demaria, J Campisi
Molecular biology of the cell 23 (11), 2066-2075, 2012
Tumor suppressor and aging biomarker p16INK4a induces cellular senescence without the associated inflammatory secretory phenotype
JP Coppé, F Rodier, CK Patil, A Freund, PY Desprez, J Campisi
Journal of Biological Chemistry 286 (42), 36396-36403, 2011
Dual SMAD signaling inhibition enables long-term expansion of diverse epithelial basal cells
H Mou, V Vinarsky, PR Tata, K Brazauskas, SH Choi, AK Crooke, B Zhang, ...
Cell stem cell 19 (2), 217-231, 2016
TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends
FL Zhong, LFZ Batista, A Freund, MF Pech, AS Venteicher, SE Artandi
Cell 150 (3), 481-494, 2012
Glucocorticoids suppress selected components of the senescence‐associated secretory phenotype
RM Laberge, L Zhou, MR Sarantos, F Rodier, A Freund, PLJ de Keizer, ...
Aging cell 11 (4), 569-578, 2012
Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1
A Freund, FL Zhong, AS Venteicher, Z Meng, TD Veenstra, J Frydman, ...
Cell 159 (6), 1389-1403, 2014
Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging
DP Muñoz, SM Yannone, A Daemen, Y Sun, F Vakar-Lopez, M Kawahara, ...
JCI insight 4 (14), 2019
An activity switch in human telomerase based on RNA conformation and shaped by TCAB1
L Chen, CM Roake, A Freund, PJ Batista, S Tian, YA Yin, CR Gajera, ...
Cell 174 (1), 218-230. e13, 2018
ARDD 2020: from aging mechanisms to interventions
GV Mkrtchyan, K Abdelmohsen, P Andreux, I Bagdonaite, N Barzilai, ...
Aging (Albany NY) 12 (24), 24484, 2020
Novel insights from a multiomics dissection of the Hayflick limit
M Chan, H Yuan, I Soifer, TM Maile, RY Wang, A Ireland, JJ O'Brien, ...
Elife 11, e70283, 2022
Untangling aging using dynamic, organism-level phenotypic networks
A Freund
Cell systems 8 (3), 172-181, 2019
Age and diet shape the genetic architecture of body weight in diversity outbred mice
KM Wright, AG Deighan, A Di Francesco, A Freund, V Jojic, GA Churchill, ...
Elife 11, e64329, 2022
Automated, high-dimensional evaluation of physiological aging and resilience in outbred mice
Z Chen, A Raj, GV Prateek, A Di Francesco, J Liu, BE Keyes, G Kolumam, ...
Elife 11, e72664, 2022
Inhibition of longevity regulator PAPP‐A modulates tissue homeostasis via restraint of mesenchymal stromal cells
M Mohrin, J Liu, J Zavala‐Solorio, S Bhargava, J Maxwell Trumble, A Brito, ...
Aging Cell 20 (3), e13313, 2021
Intermittent fasting and caloric restriction interact with genetics to shape physiological health in mice
G Zhang, A Deighan, A Raj, L Robinson, HJ Donato, G Garland, M Leland, ...
Genetics 220 (1), iyab157, 2022
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