| Development of a novel lead that targets M. tuberculosis Polyketide Synthase 13 A Aggarwal, MK Parai, N Shetty, D Wallis, L Woolhiser, C Hastings, ... Cell 170 (2), 249-259. e25, 2017 | 153 | 2017 |
| An Antibacterial β‐Lactone Kills Mycobacterium tuberculosis by Disrupting Mycolic Acid Biosynthesis J Lehmann, TY Cheng, A Aggarwal, AS Park, E Zeiler, RM Raju, ... Angewandte Chemie International Edition 57 (1), 348-353, 2018 | 66 | 2018 |
| Structural basis of BAK activation in mitochondrial apoptosis initiation G Singh, CD Guibao, J Seetharaman, A Aggarwal, CR Grace, ... Nature Communications 13 (Article number: 250), 2022 | 21 | 2022 |
| Optimization of TAM16, a benzofuran that inhibits the thioesterase activity of Pks13; evaluation toward a preclinical candidate for a novel antituberculosis clinical target C Wilson, P Ray, F Zuccotto, J Hernandez, A Aggarwal, C Mackenzie, ... Journal of Medicinal Chemistry 65 (1), 409-423, 2021 | 21 | 2021 |
| Mycobacterium tuberculosis acyl carrier protein synthase adopts two different pH-dependent structural conformations K Gokulan, A Aggarwal, L Shipman, GS Besra, JC Sacchettini Acta Crystallographica Section D: Biological Crystallography 67 (7), 657-669, 2011 | 18 | 2011 |
| Phenyl Dihydrouracil: An Alternative Cereblon Binder for PROTAC Design JA Jarusiewicz, S Yoshimura, A Mayasundari, M Actis, A Aggarwal, ... ACS Medicinal Chemistry Letters 14 (2), 141-145, 2023 | 14 | 2023 |
| A Sec14-like phosphatidylinositol transfer protein paralog defines a novel class of heme-binding proteins D Khan, D Lee, G Gulten, A Aggarwal, J Wofford, I Krieger, A Tripathi, ... eLife 9, e57081, 2020 | 12 | 2020 |
| Crystal structure of calcium dodecin (Rv0379), from Mycobacterium tuberculosis with a unique calcium‐binding site A Arockiasamy, A Aggarwal, CG Savva, A Holzenburg, JC Sacchettini Protein Science 20 (5), 827-833, 2011 | 10 | 2011 |
| Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines G Nishiguchi, LG Mascibroda, SM Young, EA Caine, S Abdelhamed, ... Nature Communications 15 (1), 482, 2024 | 4 | 2024 |
| Substituted benzofuran derivatives as novel antimycobacterial agents JC Sacchettini, A Aggarwal, MK Parai US Patent App. 15/568,268, 2018 | 4 | 2018 |
| Ein antibakterielles β‐Lacton bekämpft Mycobacterium tuberculosis durch Infiltration der Mykolsäurebiosynthese J Lehmann, TY Cheng, A Aggarwal, AS Park, E Zeiler, RM Raju, ... Angewandte Chemie 130 (1), 354-359, 2018 | 2 | 2018 |
| Rationally Designed Potent and Selective CK1α Degraders Exert Antiproliferative Activity Against a Broad Range of Human Cancer Cell Lines Z Rankovic, G Nishiguchi, S Abdelhamed, S Young, E Caine, ... | 1 | 2023 |
| Structural insights into targeted degradation of casein kinase 1-α A Young, S., Nishiguchi, G., Abdelhamed, S., Caine, E., Mascibroda, L ... Biophysical Journal 123 (3), 185A, 2024 | | 2024 |
| Structural insights into targeted degradation of casein kinase 1-α S Young, G Nishiguchi, S Abdelhamed, E Caine, L Mascibroda, ... Biophysical Journal 123 (3), 185a, 2024 | | 2024 |
| A Sec14-like Phosphatidylinositol Transfer Protein Paralog Defines a Novel Class of Heme-binding Proteins With An Unusual Heme Coordination Mechanism D Khan, D Lee, G Gulten, A Aggarwal, J Wofford, I Krieger, A Tripathi, ... bioRxiv, 2020.03. 19.999003, 2020 | | 2020 |
| Identification of Pks13 inhibitors for antitubercular drug discovery SL Quinonez, R Shrestha, A Aggarwal, A Roychowdhury, M Parai, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 255, 2018 | | 2018 |
| Synthesis and optimization of novel inhibitors targeting M. tuberculosis polyketide synthase 13 thioesterase domain R Dhakal, A Aggarwal, M Parai, R Shrestha, A Acharya, J Sacchettini. ACS National Meeting & Exposition, New Orleans, LA, United States, March 18 …, 2018 | | 2018 |
| Progress towards the synthesis of new benzofuran analogs targeting polyketide synthase 13 (Pks13) for inhibiting Mycobacterium tuberculosis (Mtb) A Gittens, D R.C., A Aggarwal, MK Parai, R Shrestha, JC Sacchettini. Abstracts, 41st Northeast Regional Meeting of the American Chemical Society …, 2016 | | 2016 |
Stephan A. SieberProfessor of Organic Chemistry, TU MunichVerified email at tum.de
