Declining Efficacy of Artemisinin Combination Therapy Against P. Falciparum Malaria on the Thai–Myanmar Border (2003–2013): The Role of Parasite Genetic … AP Phyo, EA Ashley, TJC Anderson, Z Bozdech, VI Carrara, K Sriprawat, ... Clinical infectious diseases 63 (6), 784-791, 2016 | 230 | 2016 |
Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay JM Dziekan, H Yu, D Chen, L Dai, G Wirjanata, A Larsson, N Prabhu, ... Science translational medicine 11 (473), eaau3174, 2019 | 180 | 2019 |
Cellular thermal shift assay for the identification of drug–target interactions in the Plasmodium falciparum proteome JM Dziekan, G Wirjanata, L Dai, KD Go, H Yu, YT Lim, L Chen, LC Wang, ... Nature Protocols 15 (6), 1881-1921, 2020 | 81 | 2020 |
Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target MP Wagner, P Formaglio, O Gorgette, JM Dziekan, C Huon, I Berneburg, ... Cell Reports 39 (11), 110923, 2022 | 10 | 2022 |
Genomic, transcriptomic, and metabolomic analysis of Oldenlandia corymbosa reveals the biosynthesis and mode of action of anti‐cancer metabolites I Julca, D Mutwil‐Anderwald, V Manoj, Z Khan, SK Lai, LK Yang, IT Beh, ... Journal of Integrative Plant Biology 65 (6), 1442-1466, 2023 | 9 | 2023 |
Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development G Wirjanata, J Lin, JM Dziekan, A El Sahili, Z Chung, S Tjia, NEB Zulkifli, ... bioRxiv, 2021.04. 08.438947, 2021 | 3 | 2021 |
Short tandem repeat polymorphism in the promoter region of cyclophilin 19B drives its transcriptional upregulation and contributes to drug resistance in the malaria parasite … M Kucharski, G Wirjanata, S Nayak, J Boentoro, JM Dziekan, C Assisi, ... PLoS pathogens 19 (1), e1011118, 2023 | 2 | 2023 |
Aryl amino acetamides prevent the development of Plasmodium falciparum rings via inhibition of the lipid transfer protein PfSTART1 MG Dans, C Boulet, GM Watson, W Nguyen, JM Dziekan, C Evelyn, ... bioRxiv, 2023.11. 02.565411, 2023 | 1 | 2023 |
Identification and structural validation of purine nucleoside phosphorylase from Plasmodium falciparum as a target of MMV000848 Z Chung, J Lin, G Wirjanata, JM Dziekan, A El Sahili, PR Preiser, ... Journal of Biological Chemistry 300 (1), 2024 | | 2024 |
Genetic validation of PfFKBP35 as an antimalarial drug target BT Thommen, JM Dziekan, F Achcar, S Tjia, A Passecker, K Buczak, C Gumpp, A ... eLife, https://doi.org/10.7554/eLife.86975.4, 2023 | | 2023 |
Plasmodium falciparum Eukaryotic Translation Initiation Factor 3 is Stabilized by Quinazoline-Quinoline Bisubstrate Inhibitors I Dobrescu, E Hammam, JM Dziekan, A Claës, L Halby, P Preiser, ... ACS Infectious Diseases 9 (6), 1257-1266, 2023 | | 2023 |
Peroxiredoxin 6 MP Wagner, P Formaglio, O Gorgette, JM Dziekan, C Huon, I Berneburg, ... Cell reports 39 (11), 110923-110923, 2022 | | 2022 |
Molecular analysis of antimalarial therapies: from drug development to mode of action JM Dziekan Nanyang Technological University, 2019 | | 2019 |