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Patrick M Wehrli
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Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1–40 deposition underlies plaque polymorphism in progressing Alzheimer’s disease pathology
W Michno, S Nyström, P Wehrli, T Lashley, G Brinkmalm, L Guerard, ...
Journal of Biological Chemistry 294 (17), 6719-6732, 2019
652019
Molecular imaging mass spectrometry for probing protein dynamics in neurodegenerative disease pathology
W Michno, PM Wehrli, K Blennow, H Zetterberg, J Hanrieder
Journal of neurochemistry 151 (4), 488-506, 2019
472019
GM1 locates to mature amyloid structures implicating a prominent role for glycolipid-protein interactions in Alzheimer pathology
W Michno, PM Wehrli, H Zetterberg, K Blennow, J Hanrieder
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1867 (5), 458-467, 2019
432019
Maximising the potential for bacterial phenotyping using time‐of‐flight secondary ion mass spectrometry with multivariate analysis and Tandem Mass Spectrometry
PM Wehrli, E Lindberg, TB Angerer, AE Wold, J Gottfries, JS Fletcher
Surface and interface analysis 46 (S1), 173-176, 2014
282014
Structural amyloid plaque polymorphism is associated with distinct lipid accumulations revealed by trapped ion mobility mass spectrometry imaging
W Michno, PM Wehrli, S Koutarapu, C Marsching, K Minta, J Ge, ...
Journal of Neurochemistry 160 (4), 482-498, 2022
222022
Exploring bacterial phenotypic diversity using factorial design and FTIR multivariate fingerprinting
PM Wehrli, E Lindberg, O Svensson, A Sparén, M Josefson, RH Dunstan, ...
Journal of Chemometrics 28 (8), S681-S686, 2014
212014
Chemical imaging of evolving amyloid plaque pathology and associated Aβ peptide aggregation in a transgenic mouse model of Alzheimer’s disease
W Michno, P Wehrli, SR Meier, D Sehlin, S Syvänen, H Zetterberg, ...
Journal of Neurochemistry 152 (5), 602-616, 2020
202020
Discovery and development of substituted thiadiazoles as inhibitors of Staphylococcus aureus Sortase A
PM Wehrli, I Uzelac, T Olsson, T Jacso, D Tietze, J Gottfries
Bioorganic & Medicinal Chemistry 27 (19), 115043, 2019
182019
Investigating the Role of the Stringent Response in Lipid Modifications during the Stationary Phase in E. coli by Direct Analysis with Time-of-Flight-Secondary Ion …
PM Wehrli, TB Angerer, A Farewell, JS Fletcher, J Gottfries
Analytical Chemistry 88 (17), 8680-8688, 2016
152016
Chemometric Strategies for Sensitive Annotation and Validation of Anatomical Regions of Interest in Complex Imaging Mass Spectrometry Data
PM Wehrli, W Michno, K Blennow, H Zetterberg, J Hanrieder
Journal of The American Society for Mass Spectrometry 30 (11), 2278-2288, 2019
142019
Correlative chemical imaging and spatial chemometrics delineate Alzheimer plaque heterogeneity at high spatial resolution
PM Wehrli, J Ge, W Michno, S Koutarapu, A Dreos, D Jha, H Zetterberg, ...
JACS Au 3 (3), 762-774, 2023
62023
Spatial Chemometrics and Comprehensive Chemical Imaging Based Molecular Histopathology Delineates Anatomical Heterogeneity at Single Pixel Resolution
P Wehrli, W Michno, L Guerard, J Fernandez-Rodriguez, A Bergh, ...
12020
Correlative Chemical Imaging and Spatial Chemometrics Delineate Alzheimer Plaque Heterogeneity at High Resolution
P Wehrli, J Ge, W Michno, S Koutarapu, A Dreos, D Jha, H Zetterberg, ...
2022
Amyloid Plaque Polymorphism is Associated with Distinct Lipid Accumulations Revealed by Trapped Ion Mobility Mass Spectrometry Imaging (TIMS MSI)
W Michno, P Wehrli, S Koutarapu, C Marsching, K Minta, J Ge, S Meyer, ...
2021
Towards Anti-Virulence Antimicrobials, Discovery and Development of Sortase A Inhibitors and Investigations of Bacterial Phenotypes
P Wehrli
2016
Towards Anti-Virulence Antimicrobials
PM Wehrli
University of Gothenburg, 2016
2016
Exploring bacterial phenotypic diversity using factorial design and FTIR multivariate
PM Wehrli, E Lindberg, O Svensson, A Sparén, M Josefson, RH Dunstan, ...
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Articles 1–17