| Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides HR Bridges, JN Blaza, Z Yin, I Chung, MN Pollak, J Hirst Science 379 (6630), 351-357, 2023 | 48 | 2023 |
| Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy I Chung, JJ Wright, HR Bridges, BS Ivanov, O Biner, CS Pereira, ... Nature Communications 13 (1), 2758, 2022 | 44 | 2022 |
| Cork-in-bottle mechanism of inhibitor binding to mammalian complex I I Chung, R Serreli, JB Cross, ME Di Francesco, JR Marszalek, J Hirst Science Advances 7 (20), eabg4000, 2021 | 39 | 2021 |
| Reverse Electron Transfer by Respiratory Complex I Catalyzed in a Modular Proteoliposome System JJ Wright, O Biner, I Chung, N Burger, HR Bridges, J Hirst Journal of the American Chemical Society 144 (15), 6791-6801, 2022 | 20 | 2022 |
| Preserved respiratory chain capacity and physiology in mice with profoundly reduced levels of mitochondrial respirasomes D Milenkovic, J Misic, JF Hevler, T Molinié, I Chung, I Atanassov, X Li, ... Cell Metabolism 35 (10), 1799-1813. e7, 2023 | 18 | 2023 |
| Making the leap from structure to mechanism: are the open states of mammalian complex I identified by cryoEM resting states or catalytic intermediates? I Chung, DN Grba, JJ Wright, J Hirst Current Opinion in Structural Biology 77, 102447, 2022 | 17 | 2022 |
| Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I ZA Stephenson, RF Harvey, KR Pryde, S Mistry, RE Hardy, R Serreli, ... Elife 9, e55845, 2020 | 15 | 2020 |
| Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster ANA Agip*, I Chung*, A Sanchez-Martinez*, AJ Whitworth, J Hirst Elife 12, e84424, 2023 | 14 | 2023 |
| Investigation of hydrated channels and proton pathways in a high-resolution cryo-EM structure of mammalian complex I DN Grba*, I Chung*, HR Bridges*, ANA Agip*, J Hirst Science Advances 9 (31), eadi1359, 2023 | 8 | 2023 |
| The antipsychotic medications aripiprazole, brexpiprazole and cariprazine are off-target respiratory chain complex I inhibitors RE Hardy, I Chung, Y Yu, SHY Loh, N Morone, C Soleilhavoup, ... Biology Direct 18 (1), 43, 2023 | 2 | 2023 |
| Ubiquinone-10 binding to mammalian respiratory complex I and conformational transitions associated with Q-site occupancy I Chung, JJ Wright, HR Bridges, BS Ivanov, O Biner, CS Pereira, ... Biochimica et Biophysica Acta (BBA)-Bioenergetics 1863, 148646, 2022 | | 2022 |
| Cryo-EM studies of substrate and inhibitor binding to mammalian respiratory complex I I Chung University of Cambridge, 2022 | | 2022 |
Judy HirstCambridgeVerified email at mrc-mbu.cam.ac.uk
Judy HirstCambridgeVerified email at mrc-mbu.cam.ac.uk