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Xinle Wu
Xinle Wu
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The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL
PJ Emmerson, F Wang, Y Du, Q Liu, RT Pickard, MD Gonciarz, T Coskun, ...
Nature medicine 23 (10), 1215-1219, 2017
5102017
Treating diabetes and obesity with an FGF21-mimetic antibody activating the βKlotho/FGFR1c receptor complex
IN Foltz, S Hu, C King, X Wu, C Yang, W Wang, J Weiszmann, J Stevens, ...
Science translational medicine 4 (162), 162ra153-162ra153, 2012
2342012
FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation
X Wu, H Ge, B Lemon, S Vonderfecht, J Weiszmann, R Hecht, J Gupte, ...
Journal of Biological Chemistry 285 (8), 5165-5170, 2010
2222010
The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice
AA Pieper, X Wu, TW Han, SJ Estill, Q Dang, LC Wu, S Reece-Fincanon, ...
Proceedings of the National Academy of Sciences 102 (39), 14052-14057, 2005
2142005
Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors
C Erbel-Sieler, C Dudley, Y Zhou, X Wu, SJ Estill, T Han, R Diaz-Arrastia, ...
Proceedings of the National Academy of Sciences 101 (37), 13648-13653, 2004
2032004
Co-receptor requirements for fibroblast growth factor-19 signaling
X Wu, H Ge, J Gupte, J Weiszmann, G Shimamoto, J Stevens, N Hawkins, ...
Journal of Biological Chemistry 282 (40), 29069-29072, 2007
1702007
GDF15 and growth control
PJ Emmerson, KL Duffin, S Chintharlapalli, X Wu
Frontiers in physiology 9, 1712, 2018
1642018
Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in ob/ob mice
X Li, H Ge, J Weiszmann, R Hecht, Y Li, MM Véniant, J Xu, X Wu, ...
FEBS letters 583 (19), 3230-3234, 2009
1342009
Separating mitogenic and metabolic activities of fibroblast growth factor 19 (FGF19)
X Wu, H Ge, B Lemon, S Vonderfecht, H Baribault, J Weiszmann, J Gupte, ...
Proceedings of the National Academy of Sciences 107 (32), 14158-14163, 2010
1332010
C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors
X Wu, B Lemon, XF Li, J Gupte, J Weiszmann, J Stevens, N Hawkins, ...
Journal of biological chemistry 283 (48), 33304-33309, 2008
1272008
Selective activation of FGFR4 by an FGF19 variant does not improve glucose metabolism in ob/ob mice
X Wu, H Ge, B Lemon, J Weiszmann, J Gupte, N Hawkins, X Li, J Tang, ...
Proceedings of the National Academy of Sciences 106 (34), 14379-14384, 2009
1212009
Signaling property study of adhesion G-protein-coupled receptors
J Gupte, G Swaminath, J Danao, H Tian, Y Li, X Wu
FEBS letters 586 (8), 1214-1219, 2012
1192012
Enzymatic deglycation of proteins
X Wu, VM Monnier
Archives of biochemistry and biophysics 419 (1), 16-24, 2003
1092003
Protein aging by carboxymethylation of lysines generates sites for divalent metal and redox active copper binding: relevance to diseases of glycoxidative stress
AK Saxena, P Saxena, X Wu, M Obrenovich, MF Weiss, VM Monnier
Biochemical and biophysical research communications 260 (2), 332-338, 1999
1011999
Dual actions of fibroblast growth factor 19 on lipid metabolism [S]
X Wu, H Ge, H Baribault, J Gupte, J Weiszmann, B Lemon, J Gardner, ...
Journal of lipid research 54 (2), 325-332, 2013
792013
FGF21 can be mimicked in vitro and in vivo by a novel anti-FGFR1c/β-Klotho bispecific protein
R Smith, A Duguay, A Bakker, P Li, J Weiszmann, MR Thomas, BM Alba, ...
PloS one 8 (4), e61432, 2013
712013
Chimeric polypeptides and uses thereof
Y Li, X Wu, Z Wang
US Patent 8,324,160, 2012
662012
Cloning of Amadoriase I Isoenzyme from Aspergillus sp.:  Evidence of FAD Covalently Linked to Cys342,
X Wu, M Takahashi, SG Chen, VM Monnier
Biochemistry 39 (6), 1515-1521, 2000
592000
Trefoil factor 3 (TFF3) is regulated by food intake, improves glucose tolerance and induces mucinous metaplasia
H Ge, J Gardner, X Wu, I Rulifson, J Wang, Y Xiong, J Ye, E Belouski, ...
PloS one 10 (6), e0126924, 2015
512015
Characterization of a FGF19 variant with altered receptor specificity revealed a central role for FGFR1c in the regulation of glucose metabolism
H Ge, H Baribault, S Vonderfecht, B Lemon, J Weiszmann, J Gardner, ...
PLoS One 7 (3), e33603, 2012
442012
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