|Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma|
RWK Chiu, KCA Chan, Y Gao, VYM Lau, W Zheng, TY Leung, CHF Foo, ...
Proceedings of the National Academy of Sciences 105 (51), 20458-20463, 2008
|Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus|
YMD Lo, KCA Chan, H Sun, EZ Chen, P Jiang, FMF Lun, YW Zheng, ...
Science translational medicine 2 (61), 61ra91-61ra91, 2010
|Detection and characterization of placental microRNAs in maternal plasma|
SSC Chim, TKF Shing, ECW Hung, T Leung, T Lau, RWK Chiu, ...
Clinical chemistry 54 (3), 482-490, 2008
|Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validity study|
RWK Chiu, R Akolekar, YWL Zheng, TY Leung, H Sun, KCA Chan, ...
Bmj 342, 2011
|Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients|
N Lee, KCA Chan, DS Hui, EKO Ng, A Wu, RWK Chiu, VWS Wong, ...
Journal of clinical virology 31 (4), 304-309, 2004
|Digital PCR for the molecular detection of fetal chromosomal aneuploidy|
YMD Lo, FMF Lun, KCA Chan, NBY Tsui, KC Chong, TK Lau, TY Leung, ...
Proceedings of the National Academy of Sciences 104 (32), 13116-13121, 2007
|Plasma placental RNA allelic ratio permits noninvasive prenatal chromosomal aneuploidy detection|
YM Lo, NBY Tsui, RWK Chiu, TK Lau, TN Leung, M Heung, A Gerovassili, ...
Nature medicine 13 (2), 218-223, 2007
|Predominant hematopoietic origin of cell-free DNA in plasma and serum after sex-mismatched bone marrow transplantation|
YYN Lui, KW Chik, RWK Chiu, CY Ho, CWK Lam, YMD Lo
Clinical chemistry 48 (3), 421-427, 2002
|Microfluidics digital PCR reveals a higher than expected fraction of fetal DNA in maternal plasma|
FMF Lun, RWK Chiu, KC Allen Chan, T Yeung Leung, T Kin Lau, ...
Clinical chemistry 54 (10), 1664-1672, 2008
|Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients|
P Jiang, CWM Chan, KCA Chan, SH Cheng, J Wong, VWS Wong, ...
Proceedings of the National Academy of Sciences 112 (11), E1317-E1325, 2015
|Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments|
K Sun, P Jiang, KCA Chan, J Wong, YKY Cheng, RHS Liang, W Chan, ...
Proceedings of the National Academy of Sciences 112 (40), E5503-E5512, 2015
|mRNA of placental origin is readily detectable in maternal plasma|
EKO Ng, NBY Tsui, TK Lau, TN Leung, RWK Chiu, NS Panesar, LCW Lit, ...
Proceedings of the National Academy of Sciences 100 (8), 4748-4753, 2003
|Cancer genome scanning in plasma: detection of tumor-associated copy number aberrations, single-nucleotide variants, and tumoral heterogeneity by massively parallel sequencing|
KCA Chan, P Jiang, YWL Zheng, GJW Liao, H Sun, J Wong, SSN Siu, ...
Clinical chemistry 59 (1), 211-224, 2013
|Effects of blood-processing protocols on fetal and total DNA quantification in maternal plasma|
RWK Chiu, LLM Poon, TK Lau, TN Leung, EMC Wong, YMD Lo
Clinical chemistry 47 (9), 1607-1613, 2001
|Analysis of plasma Epstein–Barr virus DNA to screen for nasopharyngeal cancer|
KCA Chan, JKS Woo, A King, BCY Zee, WKJ Lam, SL Chan, SWI Chu, ...
New England Journal of Medicine 377 (6), 513-522, 2017
|Noninvasive prenatal diagnosis of monogenic diseases by digital size selection and relative mutation dosage on DNA in maternal plasma|
FMF Lun, NBY Tsui, KCA Chan, TY Leung, TK Lau, P Charoenkwan, ...
Proceedings of the National Academy of Sciences 105 (50), 19920-19925, 2008
|Noninvasive prenatal diagnosis of fetal trisomy 18 and trisomy 13 by maternal plasma DNA sequencing|
EZ Chen, RWK Chiu, H Sun, R Akolekar, KCA Chan, TY Leung, P Jiang, ...
PloS one 6 (7), e21791, 2011
|Detection of the placental epigenetic signature of the maspin gene in maternal plasma|
SSC Chim, YK Tong, RWK Chiu, TK Lau, TN Leung, LYS Chan, ...
Proceedings of the National Academy of Sciences 102 (41), 14753-14758, 2005
|Hypermethylated RASSF1A in Maternal Plasma: A Universal Fetal DNA Marker that Improves the Reliability of Noninvasive Prenatal Diagnosis|
KCA Chan, C Ding, A Gerovassili, SW Yeung, RWK Chiu, TN Leung, ...
Clinical chemistry 52 (12), 2211-2218, 2006
|Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing|
KCA Chan, P Jiang, CWM Chan, K Sun, J Wong, EP Hui, SL Chan, ...
Proceedings of the National Academy of Sciences 110 (47), 18761-18768, 2013