关注
Patrick S. Ward, M.D., Ph.D.
Patrick S. Ward, M.D., Ph.D.
Massachusetts General Hospital
在 partners.org 的电子邮件经过验证
标题
引用次数
引用次数
年份
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
L Dang, DW White, S Gross, BD Bennett, MA Bittinger, EM Driggers, ...
Nature 462 (7274), 739-744, 2009
45572009
Metabolic reprogramming: a cancer hallmark even Warburg did not anticipate
PS Ward, CB Thompson
Cancer cell 21 (3), 297-308, 2012
33122012
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
ME Figueroa, O Abdel-Wahab, C Lu, PS Ward, J Patel, A Shih, Y Li, ...
Cancer cell 18 (6), 553-567, 2010
30272010
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting α-ketoglutarate to 2-hydroxyglutarate
PS Ward, J Patel, DR Wise, O Abdel-Wahab, BD Bennett, HA Coller, ...
Cancer cell 17 (3), 225-234, 2010
22622010
IDH mutation impairs histone demethylation and results in a block to cell differentiation
C Lu, PS Ward, GS Kapoor, D Rohle, S Turcan, O Abdel-Wahab, ...
Nature 483 (7390), 474-478, 2012
21272012
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
S Turcan, D Rohle, A Goenka, LA Walsh, F Fang, E Yilmaz, C Campos, ...
Nature 483 (7390), 479-483, 2012
21032012
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability
DR Wise, PS Ward, JES Shay, JR Cross, JJ Gruber, UM Sachdeva, ...
Proceedings of the National Academy of Sciences 108 (49), 19611-19616, 2011
10742011
MitoCarta3. 0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations
S Rath, R Sharma, R Gupta, T Ast, C Chan, TJ Durham, RP Goodman, ...
Nucleic acids research 49 (D1), D1541-D1547, 2021
8262021
Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation
J Ye, A Mancuso, X Tong, PS Ward, J Fan, JD Rabinowitz, CB Thompson
Proceedings of the National Academy of Sciences 109 (18), 6904-6909, 2012
4032012
Signaling in control of cell growth and metabolism
PS Ward, CB Thompson
Cold Spring Harbor perspectives in biology 4 (7), a006783, 2012
3042012
DNA Hydroxymethylation Profiling Reveals that WT1 Mutations Result in Loss of TET2 Function in Acute Myeloid Leukemia
R Rampal, A Alkalin, J Madzo, A Vasanthakumar, E Pronier, J Patel, Y Li, ...
Cell reports 9 (5), 1841-1855, 2014
3002014
Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition
C Chen, Y Liu, C Lu, JR Cross, JP Morris, AS Shroff, PS Ward, JE Bradner, ...
Genes & development 27 (18), 1974-1985, 2013
2102013
Identification of additional IDH mutations associated with oncometabolite R (−)-2-hydroxyglutarate production
PS Ward, JR Cross, C Lu, O Weigert, O Abel-Wahab, RL Levine, ...
Oncogene 31 (19), 2491-2498, 2012
2062012
The potential for isocitrate dehydrogenase mutations to produce 2-hydroxyglutarate depends on allele specificity and subcellular compartmentalization
PS Ward, C Lu, JR Cross, O Abdel-Wahab, RL Levine, GK Schwartz, ...
Journal of Biological Chemistry 288 (6), 3804-3815, 2013
1852013
Induction of sarcomas by mutant IDH2
C Lu, S Venneti, A Akalin, F Fang, PS Ward, RG DeMatteo, AM Intlekofer, ...
Genes & development 27 (18), 1986-1998, 2013
1772013
Combination targeted therapy to disrupt aberrant oncogenic signaling and reverse epigenetic dysfunction in IDH2-and TET2-mutant acute myeloid leukemia
AH Shih, C Meydan, K Shank, FE Garrett-Bakelman, PS Ward, ...
Cancer discovery 7 (5), 494-505, 2017
1112017
Cyclic AMP triggers glucagon-like peptide-1 secretion from the GLUTag enteroendocrine cell line
AK Simpson, PS Ward, KY Wong, GJ Collord, AM Habib, F Reimann, ...
Diabetologia 50 (10), 2181-2189, 2007
992007
Signaling mechanisms underlying the release of glucagon-like peptide 1
F Reimann, PS Ward, FM Gribble
Diabetes 55 (Supplement 2), S78-S85, 2006
872006
SnapShot: cancer metabolism pathways
LWS Finley, J Zhang, J Ye, PS Ward, CB Thompson
Cell metabolism 17 (3), 466-466. e2, 2013
582013
AG-221, a Small Molecule Mutant IDH2 Inhibitor, Remodels the Epigenetic State of IDH2-Mutant Cells and Induces Alterations in Self-Renewal/Differentiation in IDH2-Mutant AML …
AH Shih, KR Shank, C Meydan, AM Intlekofer, P Ward, CB Thompson, ...
Blood 124 (21), 437-437, 2014
372014
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