Dual modulation of cell survival and cell death by β2-adrenergic signaling in adult mouse cardiac myocytes WZ Zhu, M Zheng, WJ Koch, RJ Lefkowitz, BK Kobilka, RP Xiao Proceedings of the National Academy of Sciences 98 (4), 1607-1612, 2001 | 615 | 2001 |
Linkage of β1-adrenergic stimulation to apoptotic heart cell death through protein kinase A–independent activation of Ca2+/calmodulin kinase II WZ Zhu, SQ Wang, K Chakir, D Yang, T Zhang, JH Brown, E Devic, ... The Journal of clinical investigation 111 (5), 617-625, 2003 | 570 | 2003 |
Culture and adenoviral infection of adult mouse cardiac myocytes: methods for cellular genetic physiology YY Zhou, SQ Wang, WZ Zhu, A Chruscinski, BK Kobilka, B Ziman, S Wang, ... American Journal of Physiology-Heart and Circulatory Physiology 279 (1 …, 2000 | 372 | 2000 |
High Basal Protein Kinase A–Dependent Phosphorylation Drives Rhythmic Internal Ca2+ Store Oscillations and Spontaneous Beating of Cardiac Pacemaker Cells TM Vinogradova, AE Lyashkov, W Zhu, AM Ruknudin, S Sirenko, D Yang, ... Circulation research 98 (4), 505-514, 2006 | 327 | 2006 |
β1/β2-adrenergic receptor heterodimerization regulates β2-adrenergic receptor internalization and ERK signaling efficacy C Lavoie, JF Mercier, A Salahpour, D Umapathy, A Breit, LR Villeneuve, ... Journal of Biological Chemistry 277 (38), 35402-35410, 2002 | 302 | 2002 |
Carvedilol and its new analogs suppress arrhythmogenic store overload–induced Ca2+ release Q Zhou, J Xiao, D Jiang, R Wang, K Vembaiyan, A Wang, CD Smith, C Xie, ... Nature medicine 17 (8), 1003-1009, 2011 | 288 | 2011 |
Sustained β1-Adrenergic Stimulation Modulates Cardiac Contractility by Ca2+/Calmodulin Kinase Signaling Pathway W Wang, W Zhu, S Wang, D Yang, MT Crow, RP Xiao, H Cheng Circulation research 95 (8), 798-806, 2004 | 258 | 2004 |
Subtype-specific α1-and β-adrenoceptor signaling in the heart RP Xiao, W Zhu, M Zheng, C Cao, Y Zhang, EG Lakatta, Q Han Trends in pharmacological sciences 27 (6), 330-337, 2006 | 209 | 2006 |
CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation S Xu, P Wang, H Zhang, G Gong, N Gutierrez Cortes, W Zhu, Y Yoon, ... Nature communications 7 (1), 13189, 2016 | 202 | 2016 |
Subtype-specific β-adrenoceptor signaling pathways in the heart and their potential clinical implications RP Xiao, W Zhu, M Zheng, K Chakir, R Bond, EG Lakatta, H Cheng Trends in pharmacological sciences 25 (7), 358-365, 2004 | 201 | 2004 |
Frequency-encoding Thr17 phospholamban phosphorylation is independent of Ser16 phosphorylation in cardiac myocytes D Hagemann, M Kuschel, T Kuramochi, W Zhu, H Cheng, RP Xiao Journal of Biological Chemistry 275 (29), 22532-22536, 2000 | 179 | 2000 |
Activation of CaMKIIδC is a common intermediate of diverse death stimuli-induced heart muscle cell apoptosis W Zhu, AYH Woo, D Yang, H Cheng, MT Crow, RP Xiao Journal of Biological Chemistry 282 (14), 10833-10839, 2007 | 175 | 2007 |
Enhanced Gi Signaling Selectively Negates β2-Adrenergic Receptor (AR)– but Not β1-AR–Mediated Positive Inotropic Effect in Myocytes From Failing Rat Hearts RP Xiao, SJ Zhang, K Chakir, P Avdonin, W Zhu, RA Bond, CW Balke, ... Circulation 108 (13), 1633-1639, 2003 | 174 | 2003 |
Calmodulin kinase II inhibition protects against myocardial cell apoptosis in vivo Y Yang, WZ Zhu, M Joiner, R Zhang, CV Oddis, Y Hou, J Yang, EE Price, ... American Journal of Physiology-Heart and Circulatory Physiology 291 (6 …, 2006 | 169 | 2006 |
β2-adrenergic receptor-induced p38 MAPK activation is mediated by protein kinase A rather than by Gi or Gβγ in adult mouse cardiomyocytes M Zheng, SJ Zhang, WZ Zhu, B Ziman, BK Kobilka, RP Xiao Journal of Biological Chemistry 275 (51), 40635-40640, 2000 | 163 | 2000 |
Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction SM Schumacher, E Gao, W Zhu, X Chen, JK Chuprun, AM Feldman, ... Science translational medicine 7 (277), 277ra31-277ra31, 2015 | 161 | 2015 |
Cardioprotection by CaMKII-δB is mediated by phosphorylation of heat shock factor 1 and subsequent expression of inducible heat shock protein 70 W Peng, Y Zhang, M Zheng, H Cheng, W Zhu, CM Cao, RP Xiao Circulation research 106 (1), 102-110, 2010 | 157 | 2010 |
Mechanisms of enhanced β-adrenergic reserve from cardiac resynchronization therapy K Chakir, SK Daya, T Aiba, RS Tunin, VL Dimaano, TP Abraham, ... Circulation 119 (9), 1231-1240, 2009 | 147 | 2009 |
Protecting the myocardium: a role for the β2 adrenergic receptor in the heart AJ Patterson, W Zhu, A Chow, R Agrawal, J Kosek, RP Xiao, B Kobilka Critical care medicine 32 (4), 1041-1048, 2004 | 144 | 2004 |
Heterodimerization of β1- and β2-Adrenergic Receptor Subtypes Optimizes β-Adrenergic Modulation of Cardiac Contractility WZ Zhu, K Chakir, S Zhang, D Yang, C Lavoie, M Bouvier, TE Hébert, ... Circulation research 97 (3), 244-251, 2005 | 142 | 2005 |