Annealing as a tool for the optimization of lyophilization and ensuring of the stability of protein-loaded PLGA nanoparticles P Fonte, PR Lino, V Seabra, AJ Almeida, S Reis, B Sarmento International journal of pharmaceutics 503 (1-2), 163-173, 2016 | 51 | 2016 |
Microencapsulated SLN: an innovative strategy for pulmonary protein delivery DP Gaspar, C Serra, PR Lino, L Gonçalves, P Taboada, ... International Journal of Pharmaceutics 516 (1-2), 231-246, 2017 | 41 | 2017 |
Polyol additives modulate the in vitro stability and activity of recombinant human phenylalanine hydroxylase C Nascimento, J Leandro, PR Lino, L Ramos, AJ Almeida, IT de Almeida, ... Applied biochemistry and biotechnology 162, 192-207, 2010 | 25 | 2010 |
Phenylalanine iminoboronates as new phenylalanine hydroxylase modulators F Montalbano, J Leandro, GDVF Farias, PR Lino, RC Guedes, JB Vicente, ... Rsc Advances 4 (105), 61022-61027, 2014 | 24 | 2014 |
Microfluidic production of mRNA-loaded lipid nanoparticles for vaccine applications C Lopes, J Cristóvão, V Silvério, PR Lino, P Fonte Expert Opinion on Drug Delivery 19 (10), 1381-1395, 2022 | 18 | 2022 |
Insights into the Regulatory Domain of Cystathionine Beta‐Synthase: Characterization of Six Variant Proteins MIS Mendes, AS Santos, DEC Smith, PR Lino, HG Colaço, IT de Almeida, ... Human mutation 35 (10), 1195-1202, 2014 | 17 | 2014 |
Spray freeze drying of biologics: a review and applications for inhalation delivery S Farinha, JV Sá, PR Lino, M Galésio, J Pires, MÂ Rodrigues, ... Pharmaceutical Research 40 (5), 1115-1140, 2023 | 8 | 2023 |
Laser diffraction as a powerful tool for amorphous solid dispersion screening and dissolution understanding MC Paisana, PR Lino, PD Nunes, JF Pinto, J Henriques, AM Paiva European Journal of Pharmaceutical Sciences 163, 105853, 2021 | 8 | 2021 |
In silico and in vitro tailoring of a chitosan nanoformulation of a human metabolic enzyme PR Lino, J Leandro, M Amaro, LMD Gonçalves, P Leandro, AJ Almeida Pharmaceutics 13 (3), 329, 2021 | 6 | 2021 |
Isothermal denaturation fluorimetry vs differential scanning fluorimetry as tools for screening of stabilizers for protein freeze-drying: Human phenylalanine hydroxylase as the … P Leandro, PR Lino, R Lopes, J Leandro, MP Amaro, P Sousa, JB Vicente, ... European Journal of Pharmaceutics and Biopharmaceutics 187, 1-11, 2023 | 1 | 2023 |
Systematic Modification and Evaluation of Enzyme-Loaded Chitosan Nanoparticles PR Lino, J Leandro, L Figueiredo, MP Amaro, LMD Gonçalves, P Leandro, ... International Journal of Molecular Sciences 22 (15), 7987, 2021 | 1 | 2021 |
Leveraging Hollow Fibre Membranes and High Boiling Point Organic Solvents in the Production of Enteric Amorphous Solid Dispersions RF Mota, CM Portugal, P Lino, R Silva, AA Ricardo, J Vicente 2020 Virtual AIChE Annual Meeting, 2020 | 1 | 2020 |
Lyophilisation of human phenylalanine hydroxylase PR Lino, AJ Almeida, IT de Almeida, P Leandro FEBS JOURNAL 276, 323-323, 2009 | 1 | 2009 |
Disintegration and Dissolution Modeling for Accelerated Drug Product Process Development P Valente, S Doktorovova, N Enes, J Henriques, P Lino, I Lopes, N Neves, ... 2017 AIChE Annual Meeting, 2017 | | 2017 |
High molecular weight forms of human phenylalanine hydroxylase: the role of the ACT domain in the balance between a fully functional protein and the large inactive aggregates J Leandro, MP Amaro, PR Lino, T Flatmark, P Leandro FEBS JOURNAL 280, 119-119, 2013 | | 2013 |
PROTEIN ENGINEERING TO OBTAIN PHENYLALANINE HYDROXYLASE PROTEINS WITH HIGHER STABILITY PR Lino, C Lourenco, J Leandro, I Tavares de Almeida, AJ Almeida, ... JOURNAL OF INHERITED METABOLIC DISEASE 34, S96-S96, 2011 | | 2011 |
HOT N COLD formulation of biologics for the optimization of drying technologies S Farinha, L Marques, M Galésio, J Cristóvão, MÂ Rodrigues, P Lino | | |