Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2 R Yan, Y Zhang, Y Li, L Xia, Y Guo, Q Zhou Science 367 (6485), 1444-1448, 2020 | 5378 | 2020 |
A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2 X Chi, R Yan, J Zhang, G Zhang, Y Zhang, M Hao, Z Zhang, P Fan, ... Science 369 (6504), 650-655, 2020 | 1384 | 2020 |
Structure of the human LAT1–4F2hc heteromeric amino acid transporter complex R Yan, X Zhao, J Lei, Q Zhou Nature 568 (7750), 127-130, 2019 | 242 | 2019 |
Human SEIPIN binds anionic phospholipids R Yan, H Qian, I Lukmantara, M Gao, X Du, N Yan, H Yang Developmental cell 47 (2), 248-256. e4, 2018 | 181 | 2018 |
SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2 Q Lu, J Liu, S Zhao, MFG Castro, M Laurent-Rolle, J Dong, X Ran, ... Immunity 54 (6), 1304-1319. e9, 2021 | 133 | 2021 |
Structural basis for the recognition of the 2019-nCoV by human ACE2 R Yan, Y Zhang, Y Guo, L Xia, Q Zhou BioRxiv, 2020.02. 19.956946, 2020 | 95 | 2020 |
Structural basis for the different states of the spike protein of SARS-CoV-2 in complex with ACE2 R Yan, Y Zhang, Y Li, F Ye, Y Guo, L Xia, X Zhong, X Chi, Q Zhou Cell research 31 (6), 717-719, 2021 | 87 | 2021 |
Engineered trimeric ACE2 binds viral spike protein and locks it in “Three-up” conformation to potently inhibit SARS-CoV-2 infection L Guo, W Bi, X Wang, W Xu, R Yan, Y Zhang, K Zhao, Y Li, M Zhang, ... Cell Research 31 (1), 98-100, 2021 | 80 | 2021 |
Structural basis for catalysis and substrate specificity of human ACAT1 H Qian, X Zhao, R Yan, X Yao, S Gao, X Sun, X Du, H Yang, CCL Wong, ... Nature 581 (7808), 333-338, 2020 | 76 | 2020 |
Neutralization mechanism of a human antibody with pan-coronavirus reactivity including SARS-CoV-2 X Sun, C Yi, Y Zhu, L Ding, S Xia, X Chen, M Liu, C Gu, X Lu, Y Fu, ... Nature Microbiology 7 (7), 1063-1074, 2022 | 72 | 2022 |
Structure of dimeric full-length human ACE2 in complex with B0AT1 R Yan, Y Zhang, Y Li, L Xia, Q Zhou BioRxiv, 2020.02. 17.951848, 2020 | 72 | 2020 |
Antibody-dependent enhancement (ADE) of SARS-CoV-2 infection in recovered COVID-19 patients: studies based on cellular and structural biology analysis F Wu, R Yan, M Liu, Z Liu, Y Wang, D Luan, K Wu, Z Song, T Sun, Y Ma, ... MedRxiv, 2020.10. 08.20209114, 2020 | 62 | 2020 |
Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies R Yan, R Wang, B Ju, J Yu, Y Zhang, N Liu, J Wang, Q Zhang, P Chen, ... Cell research 31 (5), 517-525, 2021 | 57 | 2021 |
A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols R Yan, P Cao, W Song, H Qian, X Du, HW Coates, X Zhao, Y Li, S Gao, ... Science 371 (6533), eabb2224, 2021 | 56 | 2021 |
The structure of erastin-bound xCT–4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis R Yan, E Xie, Y Li, J Li, Y Zhang, X Chi, X Hu, L Xu, T Hou, BR Stockwell, ... Cell research 32 (7), 687-690, 2022 | 55 | 2022 |
Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter R Yan, Y Li, J Müller, Y Zhang, S Singer, L Xia, X Zhong, J Gertsch, ... Cell discovery 7 (1), 16, 2021 | 50 | 2021 |
ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker Y Chen, YN Zhang, R Yan, G Wang, Y Zhang, ZR Zhang, Y Li, J Ou, ... Signal transduction and targeted therapy 6 (1), 315, 2021 | 44 | 2021 |
A potent neutralizing human antibody reveals the N-terminal domain of the Spike protein of SARS-CoV-2 as a site of vulnerability X Chi, R Yan, J Zhang, G Zhang, Y Zhang, M Hao, Z Zhang, P Fan, ... BioRxiv, 2020.05. 08.083964, 2020 | 44 | 2020 |
Cryo-EM structure of the human heteromeric amino acid transporter b0,+AT-rBAT R Yan, Y Li, Y Shi, J Zhou, J Lei, J Huang, Q Zhou Science Advances 6 (16), eaay6379, 2020 | 30 | 2020 |
Novel sarbecovirus bispecific neutralizing antibodies with exceptional breadth and potency against currently circulating SARS-CoV-2 variants and sarbecoviruses Y Wang, M Liu, Y Shen, Y Ma, X Li, Y Zhang, M Liu, XL Yang, J Chen, ... Cell Discovery 8 (1), 36, 2022 | 25 | 2022 |