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Ryan G Lim
Ryan G Lim
Verified email at uci.edu
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Year
The library of integrated network-based cellular signatures NIH program: system-level cataloging of human cells response to perturbations
AB Keenan, SL Jenkins, KM Jagodnik, S Koplev, E He, D Torre, Z Wang, ...
Cell systems 6 (1), 13-24, 2018
3922018
Huntington’s disease iPSC-derived brain microvascular endothelial cells reveal WNT-mediated angiogenic and blood-brain barrier deficits
RG Lim, C Quan, AM Reyes-Ortiz, SE Lutz, AJ Kedaigle, TA Gipson, J Wu, ...
Cell reports 19 (7), 1365-1377, 2017
2322017
Modeling psychomotor retardation using iPSCs from MCT8-deficient patients indicates a prominent role for the blood-brain barrier
GD Vatine, A Al-Ahmad, BK Barriga, S Svendsen, A Salim, L Garcia, ...
Cell stem cell 20 (6), 831-843. e5, 2017
2052017
Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice
Nature neuroscience 20 (5), 648-660, 2017
1862017
SIRT2-and NRF2-targeting thiazole-containing compound with therapeutic activity in Huntington's disease models
L Quinti, M Casale, S Moniot, TF Pais, MJ Van Kanegan, LS Kaltenbach, ...
Cell chemical biology 23 (7), 849-861, 2016
842016
Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines
EG Baxi, T Thompson, J Li, JA Kaye, RG Lim, J Wu, D Ramamoorthy, ...
Nature neuroscience 25 (2), 226-237, 2022
792022
A comparison of mRNA sequencing with random primed and 3′-directed libraries
Y Xiong, M Soumillon, J Wu, J Hansen, B Hu, JG Van Hasselt, ...
Scientific reports 7 (1), 1-12, 2017
622017
Aberrant development corrected in adult-onset Huntington's disease iPSC-derived neuronal cultures via WNT signaling modulation
C Smith-Geater, SJ Hernandez, RG Lim, M Adam, J Wu, JT Stocksdale, ...
Stem cell reports 14 (3), 406-419, 2020
472020
Bioenergetic deficits in Huntington’s disease iPSC-derived neural cells and rescue with glycolytic metabolites
Human molecular genetics 29 (11), 1757-1771, 2020
412020
Huntington’s disease mice and human brain tissue exhibit increased G3BP1 granules and TDP43 mislocalization
II Sanchez, TB Nguyen, WE England, RG Lim, AQ Vu, R Miramontes, ...
The Journal of clinical investigation 131 (12), 2021
392021
PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington’s disease
EL Morozko, C Smith-Geater, AM Monteys, S Pradhan, RG Lim, ...
Proceedings of the National Academy of Sciences 118 (4), e2021836118, 2021
312021
An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients
H Phatnani, J Kwan, D Sareen, JR Broach, Z Simmons, X Arcila-Londono, ...
Iscience 24 (11), 103221, 2021
262021
IKKβ slows Huntington’s disease progression in R6/1 mice
J Ochaba, G Fote, M Kachemov, S Thein, SY Yeung, AL Lau, ...
Proceedings of the National Academy of Sciences 116 (22), 10952-10961, 2019
242019
Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects
MJ Workman, RG Lim, J Wu, A Frank, L Ornelas, L Panther, E Galvez, ...
Neuron, 2023
232023
Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation
RG Lim, O Al-Dalahmah, J Wu, MP Gold, JC Reidling, G Tang, M Adam, ...
Nature Communications 13 (1), 7791, 2022
162022
Identifying patterns in amyotrophic lateral sclerosis progression from sparse longitudinal data
D Ramamoorthy, K Severson, S Ghosh, K Sachs, JD Glass, CN Fournier, ...
Nature Computational Science 2 (9), 605-616, 2022
142022
Treatment with JQ1, a BET bromodomain inhibitor, is selectively detrimental to R6/2 Huntington’s disease mice
AJ Kedaigle, JC Reidling, RG Lim, M Adam, J Wu, B Wassie, ...
Human molecular genetics 29 (2), 202-215, 2020
132020
Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits
AM Reyes-Ortiz, EM Abud, MS Burns, J Wu, SJ Hernandez, N McClure, ...
Iscience 26 (1), 105732, 2023
52023
NeuroLINCS Proteomics: Defining human-derived iPSC proteomes and protein signatures of pluripotency
AD Matlock, V Vaibhav, R Holewinski, V Venkatraman, V Dardov, ...
Scientific Data 10 (1), 24, 2023
42023
An altered extracellular matrix-integrin interface contributes to Huntington’s disease-associated CNS dysfunction in glial and vascular cells
SJ Hernandez, RG Lim, T Onur, MA Dane, R Smith, K Wang, GEH Jean, ...
Human Molecular Genetics, 2022
42022
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