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Huntington’s disease iPSC-derived brain microvascular endothelial cells reveal WNT-mediated angiogenic and blood-brain barrier deficits RG Lim, C Quan, AM Reyes-Ortiz, SE Lutz, AJ Kedaigle, TA Gipson, J Wu, ... Cell reports 19 (7), 1365-1377, 2017 | 232 | 2017 |
Modeling psychomotor retardation using iPSCs from MCT8-deficient patients indicates a prominent role for the blood-brain barrier GD Vatine, A Al-Ahmad, BK Barriga, S Svendsen, A Salim, L Garcia, ... Cell stem cell 20 (6), 831-843. e5, 2017 | 205 | 2017 |
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SIRT2-and NRF2-targeting thiazole-containing compound with therapeutic activity in Huntington's disease models L Quinti, M Casale, S Moniot, TF Pais, MJ Van Kanegan, LS Kaltenbach, ... Cell chemical biology 23 (7), 849-861, 2016 | 84 | 2016 |
Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines EG Baxi, T Thompson, J Li, JA Kaye, RG Lim, J Wu, D Ramamoorthy, ... Nature neuroscience 25 (2), 226-237, 2022 | 79 | 2022 |
A comparison of mRNA sequencing with random primed and 3′-directed libraries Y Xiong, M Soumillon, J Wu, J Hansen, B Hu, JG Van Hasselt, ... Scientific reports 7 (1), 1-12, 2017 | 62 | 2017 |
Aberrant development corrected in adult-onset Huntington's disease iPSC-derived neuronal cultures via WNT signaling modulation C Smith-Geater, SJ Hernandez, RG Lim, M Adam, J Wu, JT Stocksdale, ... Stem cell reports 14 (3), 406-419, 2020 | 47 | 2020 |
Bioenergetic deficits in Huntington’s disease iPSC-derived neural cells and rescue with glycolytic metabolites Human molecular genetics 29 (11), 1757-1771, 2020 | 41 | 2020 |
Huntington’s disease mice and human brain tissue exhibit increased G3BP1 granules and TDP43 mislocalization II Sanchez, TB Nguyen, WE England, RG Lim, AQ Vu, R Miramontes, ... The Journal of clinical investigation 131 (12), 2021 | 39 | 2021 |
PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington’s disease EL Morozko, C Smith-Geater, AM Monteys, S Pradhan, RG Lim, ... Proceedings of the National Academy of Sciences 118 (4), e2021836118, 2021 | 31 | 2021 |
An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients H Phatnani, J Kwan, D Sareen, JR Broach, Z Simmons, X Arcila-Londono, ... Iscience 24 (11), 103221, 2021 | 26 | 2021 |
IKKβ slows Huntington’s disease progression in R6/1 mice J Ochaba, G Fote, M Kachemov, S Thein, SY Yeung, AL Lau, ... Proceedings of the National Academy of Sciences 116 (22), 10952-10961, 2019 | 24 | 2019 |
Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects MJ Workman, RG Lim, J Wu, A Frank, L Ornelas, L Panther, E Galvez, ... Neuron, 2023 | 23 | 2023 |
Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation RG Lim, O Al-Dalahmah, J Wu, MP Gold, JC Reidling, G Tang, M Adam, ... Nature Communications 13 (1), 7791, 2022 | 16 | 2022 |
Identifying patterns in amyotrophic lateral sclerosis progression from sparse longitudinal data D Ramamoorthy, K Severson, S Ghosh, K Sachs, JD Glass, CN Fournier, ... Nature Computational Science 2 (9), 605-616, 2022 | 14 | 2022 |
Treatment with JQ1, a BET bromodomain inhibitor, is selectively detrimental to R6/2 Huntington’s disease mice AJ Kedaigle, JC Reidling, RG Lim, M Adam, J Wu, B Wassie, ... Human molecular genetics 29 (2), 202-215, 2020 | 13 | 2020 |
Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits AM Reyes-Ortiz, EM Abud, MS Burns, J Wu, SJ Hernandez, N McClure, ... Iscience 26 (1), 105732, 2023 | 5 | 2023 |
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An altered extracellular matrix-integrin interface contributes to Huntington’s disease-associated CNS dysfunction in glial and vascular cells SJ Hernandez, RG Lim, T Onur, MA Dane, R Smith, K Wang, GEH Jean, ... Human Molecular Genetics, 2022 | 4 | 2022 |