|Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma|
RWK Chiu, KCA Chan, Y Gao, VYM Lau, W Zheng, TY Leung, CHF Foo, ...
Proceedings of the National Academy of Sciences 105 (51), 20458-20463, 2008
|Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus|
YMD Lo, KCA Chan, H Sun, EZ Chen, P Jiang, FMF Lun, YW Zheng, ...
Science translational medicine 2 (61), 61ra91-61ra91, 2010
|Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validity study|
RWK Chiu, R Akolekar, YWL Zheng, TY Leung, H Sun, KCA Chan, ...
Bmj 342, 2011
|Size distributions of maternal and fetal DNA in maternal plasma|
KCA Chan, J Zhang, ABY Hui, N Wong, TK Lau, TN Leung, KW Lo, ...
Clinical chemistry 50 (1), 88-92, 2004
|Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A (H1N1) 2009 virus infection|
IFN Hung, KKW To, CK Lee, KL Lee, K Chan, WW Yan, R Liu, CL Watt, ...
Clinical Infectious Diseases 52 (4), 447-456, 2011
|Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients|
N Lee, KCA Chan, DS Hui, EKO Ng, A Wu, RWK Chiu, VWS Wong, ...
Journal of clinical virology 31 (4), 304-309, 2004
|Digital PCR for the molecular detection of fetal chromosomal aneuploidy|
YMD Lo, FMF Lun, KCA Chan, NBY Tsui, KC Chong, TK Lau, TY Leung, ...
Proceedings of the National Academy of Sciences 104 (32), 13116-13121, 2007
|Microfluidics digital PCR reveals a higher than expected fraction of fetal DNA in maternal plasma|
FMF Lun, RWK Chiu, KC Allen Chan, T Yeung Leung, T Kin Lau, ...
Clinical chemistry 54 (10), 1664-1672, 2008
|Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients|
P Jiang, CWM Chan, KCA Chan, SH Cheng, J Wong, VWS Wong, ...
Proceedings of the National Academy of Sciences 112 (11), E1317-E1325, 2015
|Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments|
K Sun, P Jiang, KCA Chan, J Wong, YKY Cheng, RHS Liang, W Chan, ...
Proceedings of the National Academy of Sciences 112 (40), E5503-E5512, 2015
|Cancer genome scanning in plasma: detection of tumor-associated copy number aberrations, single-nucleotide variants, and tumoral heterogeneity by massively parallel sequencing|
KCA Chan, P Jiang, YWL Zheng, GJW Liao, H Sun, J Wong, SSN Siu, ...
Clinical chemistry 59 (1), 211-224, 2013
|Analysis of plasma Epstein–Barr virus DNA to screen for nasopharyngeal cancer|
KCA Chan, JKS Woo, A King, BCY Zee, WKJ Lam, SL Chan, SWI Chu, ...
New England Journal of Medicine 377 (6), 513-522, 2017
|Single-molecule detection of epidermal growth factor receptor mutations in plasma by microfluidics digital PCR in non–small cell lung cancer patients|
TKF Yung, KC Chan, TSK Mok, J Tong, KF To, YM Lo
Clinical Cancer Research 15 (6), 2076-2084, 2009
|Noninvasive prenatal diagnosis of monogenic diseases by digital size selection and relative mutation dosage on DNA in maternal plasma|
FMF Lun, NBY Tsui, KCA Chan, TY Leung, TK Lau, P Charoenkwan, ...
Proceedings of the National Academy of Sciences 105 (50), 19920-19925, 2008
|Noninvasive prenatal diagnosis of fetal trisomy 18 and trisomy 13 by maternal plasma DNA sequencing|
EZ Chen, RWK Chiu, H Sun, R Akolekar, KCA Chan, TY Leung, P Jiang, ...
PloS one 6 (7), e21791, 2011
|Hypermethylated RASSF1A in Maternal Plasma: A Universal Fetal DNA Marker that Improves the Reliability of Noninvasive Prenatal Diagnosis|
KCA Chan, C Ding, A Gerovassili, SW Yeung, RWK Chiu, TN Leung, ...
Clinical chemistry 52 (12), 2211-2218, 2006
|Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing|
KCA Chan, P Jiang, CWM Chan, K Sun, J Wong, EP Hui, SL Chan, ...
Proceedings of the National Academy of Sciences 110 (47), 18761-18768, 2013
|Plasma Epstein-Barr viral deoxyribonucleic acid quantitation complements tumor-node-metastasis staging prognostication in nasopharyngeal carcinoma|
S Leung, B Zee, BB Ma, EP Hui, F Mo, M Lai, KCA Chan, LYS Chan, ...
Journal of clinical oncology 24 (34), 5414-5418, 2006
|Hyperimmune IV immunoglobulin treatment: a multicenter double-blind randomized controlled trial for patients with severe 2009 influenza A (H1N1) infection|
IFN Hung, KKW To, CK Lee, KL Lee, WW Yan, K Chan, WM Chan, ...
Chest 144 (2), 464-473, 2013
|Size-based molecular diagnostics using plasma DNA for noninvasive prenatal testing|
SCY Yu, KCA Chan, YWL Zheng, P Jiang, GJW Liao, H Sun, R Akolekar, ...
Proceedings of the National Academy of Sciences 111 (23), 8583-8588, 2014