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Brian Safina
Brian Safina
Magnet Biomedicine
Verified email at magnetbio.com
Title
Cited by
Cited by
Year
A mild and selective method for the hydrolysis of esters with trimethyltin hydroxide
KC Nicolaou, AA Estrada, M Zak, SH Lee, BS Safina
Angewandte Chemie 117 (9), 1402-1406, 2005
5202005
Structural basis of Nav1. 7 inhibition by an isoform-selective small-molecule antagonist
S Ahuja, S Mukund, L Deng, K Khakh, E Chang, H Ho, S Shriver, C Young, ...
Science 350 (6267), aac5464, 2015
3112015
Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors
JF Blake, R Xu, JR Bencsik, D Xiao, NC Kallan, S Schlachter, IS Mitchell, ...
Journal of medicinal chemistry 55 (18), 8110-8127, 2012
1802012
Total synthesis of thiostrepton. Retrosynthetic analysis and construction of key building blocks
KC Nicolaou, BS Safina, M Zak, SH Lee, M Nevalainen, M Bella, ...
Journal of the American Chemical Society 127 (31), 11159-11175, 2005
1542005
Total synthesis of thiostrepton. Assembly of key building blocks and completion of the synthesis
KC Nicolaou, M Zak, BS Safina, AA Estrada, SH Lee, M Nevalainen
Journal of the American Chemical Society 127 (31), 11176-11183, 2005
1162005
Total synthesis of thiostrepton, part 2: construction of the quinaldic acid macrocycle and final stages of the synthesis
KC Nicolaou, M Zak, BS Safina, SH Lee, AA Estrada
Angewandte Chemie 116 (38), 5202-5207, 2004
1132004
Total synthesis of thiostrepton, Part 1: construction of the dehydropiperidine/thiazoline‐containing macrocycle
KC Nicolaou, BS Safina, M Zak, AA Estrada, SH Lee
Angewandte Chemie International Edition 43 (38), 5087-5092, 2004
1122004
Immune-stimulating antibody conjugates elicit robust myeloid activation and durable antitumor immunity
SE Ackerman, CI Pearson, JD Gregorio, JC Gonzalez, JA Kenkel, ...
Nature Cancer 2 (1), 18-33, 2021
932021
Discovery of peptidomimetic antibody–drug conjugate linkers with enhanced protease specificity
BQ Wei, J Gunzner-Toste, H Yao, T Wang, J Wang, Z Xu, J Chen, J Wai, ...
Journal of medicinal chemistry 61 (3), 989-1000, 2018
902018
A biomimetically inspired synthesis of the dehydropiperidine domain of thiostrepton
KC Nicolaou, M Nevalainen, BS Safina, M Zak, S Bulat
Angewandte Chemie 114 (11), 2021-2025, 2002
832002
Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models
T Focken, S Liu, N Chahal, M Dauphinais, ME Grimwood, S Chowdhury, ...
ACS medicinal chemistry letters 7 (3), 277-282, 2016
762016
Potent and highly selective benzimidazole inhibitors of PI3-kinase delta
JM Murray, ZK Sweeney, BK Chan, M Balazs, E Bradley, G Castanedo, ...
Journal of medicinal chemistry 55 (17), 7686-7695, 2012
752012
A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment
A Balestrini, V Joseph, M Dourado, RM Reese, SD Shields, L Rougé, ...
Journal of Experimental Medicine 218 (4), 2021
722021
Discovery of novel PI3-kinase δ specific inhibitors for the treatment of rheumatoid arthritis: taming CYP3A4 time-dependent inhibition
BS Safina, S Baker, M Baumgardner, PM Blaney, BK Chan, YH Chen, ...
Journal of medicinal chemistry 55 (12), 5887-5900, 2012
722012
Synthetic Studies on Thiostrepton: Construction of Thiostrepton Analogues with the Thiazoline‐Containing Macrocycle
KC Nicolaou, M Nevalainen, M Zak, S Bulat, M Bella, BS Safina
Angewandte Chemie 115 (29), 3540-3546, 2003
672003
A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability
TE Rawson, M Rüth, E Blackwood, D Burdick, L Corson, J Dotson, ...
Journal of medicinal chemistry 51 (15), 4465-4475, 2008
652008
N-substituted benzamides and methods of use thereof
S Chowdhury, CM Dehnhardt, T Focken, ME Grimwood, IW Hemeon, ...
US Patent 8,933,236, 2015
622015
Potent and selective inhibitors of PI3Kδ: Obtaining isoform selectivity from the affinity pocket and tryptophan shelf
DP Sutherlin, S Baker, A Bisconte, PM Blaney, A Brown, BK Chan, ...
Bioorganic & medicinal chemistry letters 22 (13), 4296-4302, 2012
622012
A non-covalent ligand reveals biased agonism of the TRPA1 ion channel
C Liu, R Reese, S Vu, L Rougé, SD Shields, S Kakiuchi-Kiyota, H Chen, ...
Neuron 109 (2), 273-284. e4, 2021
602021
Selective NaV1. 7 antagonists with long residence time show improved efficacy against inflammatory and neuropathic pain
G Bankar, SJ Goodchild, S Howard, K Nelkenbrecher, M Waldbrook, ...
Cell reports 24 (12), 3133-3145, 2018
532018
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