Lei He
Lei He
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PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA proficient triple negative breast cancer to PARP inhibition
YH Ibrahim, C García-García, V Serra, L He, K Torres-Lockhart, A Prat, ...
Cancer Discovery, 2012
TBCRC009: a multicenter phase II clinical trial of platinum monotherapy with biomarker assessment in metastatic triple-negative breast cancer
SJ Isakoff, EL Mayer, L He, TA Traina, LA Carey, KJ Krag, HS Rugo, ...
Journal of clinical oncology 33 (17), 1902, 2015
Analysis and update of the human solute carrier (SLC) gene superfamily
L He, K Vasiliou, DW Nebert
Hum Genomics 3 (2), 195-206, 2009
ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter family: characterization of transporter properties
L He, K Girijashanker, TP Dalton, J Reed, H Li, M Soleimani, DW Nebert
Molecular pharmacology 70 (1), 171-180, 2006
Slc39a14 gene encodes ZIP14, a metal/bicarbonate symporter: similarities to the ZIP8 transporter
K Girijashanker, L He, M Soleimani, JM Reed, H Li, Z Liu, B Wang, ...
Molecular pharmacology 73 (5), 1413-1423, 2008
Identification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testis
TP Dalton, L He, B Wang, ML Miller, L Jin, KF Stringer, X Chang, ...
Proceedings of the National Academy of Sciences 102 (9), 3401-3406, 2005
Cd2+ versus Zn2+ uptake by the ZIP8 HCO3--dependent symporter: kinetics, electrogenicity and trafficking
Z Liu, H Li, M Soleimani, K Girijashanker, JM Reed, L He, TP Dalton, ...
Biochemical and biophysical research communications 365 (4), 814-820, 2008
Discovery of ZIP transporters that participate in cadmium damage to testis and kidney
L He, B Wang, EB Hay, DW Nebert
Toxicology and applied pharmacology 238 (3), 250-257, 2009
Enhanced cadmium-induced testicular necrosis and renal proximal tubule damage caused by gene-dose increase in a Slc39a8-transgenic mouse line
B Wang, SN Schneider, N Dragin, K Girijashanker, TP Dalton, L He, ...
American Journal of Physiology-Cell Physiology 292 (4), C1523-C1535, 2007
Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma
MR Ramsey, L He, N Forster, B Ory, LW Ellisen
Cancer research 71 (13), 4373-4379, 2011
ZIP8 Zinc Transporter: Indispensable Role for Both Multiple-Organ Organogenesis and Hematopoiesis In Utero
M Gálvez-Peralta, L He, LF Jorge-Nebert, B Wang, ML Miller, BL Eppert, ...
PloS one 7 (5), e36055, 2012
PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA-proficient triple-negative breast cancer to PARP inhibition. Cancer Discov. 2012; 2: 1036–1047. doi: 10.1158/2159 …
YH Ibrahim, C García-García, V Serra, L He, K Torres-Lockhart, A Prat, ...
vitro/in vivo, 2013
Mcl-1 and FBW7 control a dominant survival pathway underlying HDAC and Bcl-2 inhibitor synergy in squamous cell carcinoma
L He, K Torres-Lockhart, N Forster, S Ramakrishnan, P Greninger, ...
Cancer Discovery, 2012
Safety and tolerability of veliparib combined with capecitabine plus radiotherapy in patients with locally advanced rectal cancer: a phase 1b study.
MM Czito BG, Deming DA, Jameson GS, Mulcahy MF, Vaghefi H, Dudley MW, Holen ...
Lancet Gastroenterol Hepatol., 2017
ZIP14 and ZIP8 zinc/bicarbonate symporters in Xenopus oocytes: characterization of metal uptake and inhibition
DW Nebert, M Gálvez-Peralta, EB Hay, H Li, E Johansson, C Yin, B Wang, ...
Metallomics, 2012
A role for BRCA1 in uterine leiomyosarcoma
D Xing, G Scangas, M Nitta, L He, X Xu, YJM Ioffe, PJ Aspuria, CY Hedvat, ...
Cancer research 69 (21), 8231-8235, 2009
BRCA1-associated epigenetic regulation of p73 mediates an effector pathway for chemosensitivity in ovarian carcinoma
N Ibrahim, L He, CO Leong, D Xing, BY Karlan, EM Swisher, BR Rueda, ...
Cancer research 70 (18), 7155-7165, 2010
Veliparib in combination with carboplatin and etoposide in patients with treatment-naïve extensive-stage small cell lung cancer: a phase 2 randomized study
LA Byers, D Bentsion, S Gans, K Penkov, CH Son, A Sibille, ...
Clinical Cancer Research 27 (14), 3884-3895, 2021
Generation of a Slc39a8 hypomorph mouse: Markedly decreased ZIP8 Zn 2+/transporter expression
B Wang, L He, H Dong, TP Dalton, DW Nebert
Biochemical and Biophysical Research Communications 410 (2), 289-294, 2011
A phase I dose-escalation study of veliparib combined with carboplatin and etoposide in patients with extensive-stage small cell lung cancer and other solid tumors
F Atrafi, HJM Groen, LA Byers, E Garralda, MP Lolkema, RS Sangha, ...
Clinical Cancer Research 25 (2), 496-505, 2019
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