Nicholas P. Farrell
Nicholas P. Farrell
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Transition metal complexes as drugs and chemotherapeutic agents
N Farrell
Springer Science & Business Media, 2012
Activation of the trans geometry in platinum antitumor complexes. Synthesis, characterization, and biological activity of complexes with the planar ligands pyridine, N …
M Van Beusichem, N Farrell
Inorganic Chemistry 31 (4), 634-639, 1992
DNA modifications by a novel bifunctional trinuclear platinum phase I anticancer agent
V Brabec, J Kašpárková, O Vrána, O Nováková, JW Cox, Y Qu, N Farrell
Biochemistry 38 (21), 6781-6790, 1999
Activation of the trans Geometry in Platinum Antitumor Complexes: A Survey of the Cytotoxicity of trans Complexes Containing Planar Ligands in Murine L1210 …
N Farrell, LR Kelland, JD Roberts, M Van Beusichem
Cancer Research 52 (18), 5065-5072, 1992
Biomedical uses and applications of inorganic chemistry. An overview
N Farrell
Coordination Chemistry Reviews 232 (1-2), 1-4, 2002
A comparison of chemical reactivity, cytotoxicity, interstrand crosslinking and DNA sequence specificity of bis (platinum) complexes containing monodentate or bidentate …
N Farrell, Y Qu, L Feng, B Van Houten
Biochemistry 29 (41), 9522-9531, 1990
BBR 3464: a novel triplatinum complex, exhibiting a preclinical profile of antitumor efficacy different from cisplatin
C Manzotti, G Pratesi, E Menta, R Di Domenico, E Cavalletti, HH Fiebig, ...
Clinical cancer research 6 (7), 2626-2634, 2000
Cytostatic trans-platinum (II) complexes
N Farrell, TTB Ha, JP Souchard, FL Wimmer, S Cros, NP Johnson
Journal of medicinal chemistry 32 (10), 2240-2241, 1989
LR Kelland, NP Farrell
Cytotoxicity and antitumor activity of bis (platinum) complexes. A novel class of platinum complexes active in cell lines resistant to both cisplatin and 1, 2 …
N Farrell, Y Qu, MP Hacker
Journal of medicinal chemistry 33 (8), 2179-2184, 1990
Current status of structure-activity relationships of platinum anticancer drugs: activation of the trans geometry
N Farrell
Metal ions in biological systems 32, 603-639, 1996
A third mode of DNA binding: phosphate clamps by a polynuclear platinum complex
S Komeda, T Moulaei, KK Woods, M Chikuma, NP Farrell, LD Williams
Journal of the American Chemical Society 128 (50), 16092-16103, 2006
Polynuclear platinum drugs
N Farrell
Metal ions in biological systems 42, 251-296, 2004
A novel trinuclear platinum complex overcomes cisplatin resistance in an osteosarcoma cell system
P Perego, C Caserini, L Gatti, N Carenini, S Romanelli, R Supino, ...
Molecular pharmacology 55 (3), 528-534, 1999
Transferring the concept of multinuclearity to ruthenium complexes for improvement of anticancer activity
MG Mendoza-Ferri, CG Hartinger, MA Mendoza, M Groessl, AE Egger, ...
Journal of medicinal chemistry 52 (4), 916-925, 2009
DNA interstrand cross-links of the novel antitumor trinuclear platinum complex BBR3464: conformation, recognition by high mobility group domain proteins, and nucleotide …
J Kasparkova, J Zehnulova, N Farrell, V Brabec
Journal of Biological Chemistry 277 (50), 48076-48086, 2002
Zinc metalloproteins as medicinal targets
AI Anzellotti, NP Farrell
Chemical Society Reviews 37 (8), 1629-1651, 2008
Metal complexes as drugs and chemotherapeutic agents
N Farrell
Pergamon, 2003
Nonclassical platinum antitumor agents: perspectives for design and development of new drugs complementary to cisplatin
N Farrell
Cancer investigation 11 (5), 578-589, 1993
Effects of geometric isomerism and ligand substitution in bifunctional dinuclear platinum complexes on binding properties and conformational changes in DNA
N Farrell, TG Appleton, Y Qu, JD Roberts, APS Fontes, KA Skov, P Wu, ...
Biochemistry 34 (47), 15480-15486, 1995
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