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Ayat Zagzoog
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In vitro and in vivo pharmacological activity of minor cannabinoids isolated from Cannabis sativa
A Zagzoog, KA Mohamed, HJJ Kim, ED Kim, CS Frank, T Black, ...
Scientific Reports 10 (1), 20405, 2020
1712020
Application of fluorine-and nitrogen-walk approaches: defining the structural and functional diversity of 2-phenylindole class of cannabinoid 1 receptor positive allosteric …
S Garai, PM Kulkarni, PC Schaffer, LM Leo, AL Brandt, A Zagzoog, ...
Journal of medicinal chemistry 63 (2), 542-568, 2019
592019
Assessment of select synthetic cannabinoid receptor agonist bias and selectivity between the type 1 and type 2 cannabinoid receptor
A Zagzoog, AL Brandt, T Black, ED Kim, R Burkart, M Patel, Z Jin, ...
Scientific Reports 11 (1), 10611, 2021
352021
Dissociable changes in spike and wave discharges following exposure to injected cannabinoids and smoked cannabis in Genetic Absence Epilepsy Rats from Strasbourg
AJ Roebuck, Q Greba, TJ Onofrychuk, DL McElroy, TM Sandini, ...
European Journal of Neuroscience 55 (4), 1063-1078, 2022
302022
Discovery of a biased allosteric modulator for cannabinoid 1 receptor: preclinical anti-glaucoma efficacy
S Garai, LM Leo, AM Szczesniak, DP Hurst, PC Schaffer, A Zagzoog, ...
Journal of Medicinal Chemistry 64 (12), 8104-8126, 2021
292021
Impact of the mouse estrus cycle on cannabinoid receptor agonist‐induced molecular and behavioral outcomes
HJJ Kim, A Zagzoog, T Black, SL Baccetto, UC Ezeaka, RB Laprairie
Pharmacology research & perspectives 10 (3), e00950, 2022
212022
Modulation of type 1 cannabinoid receptor activity by cannabinoid by-products from Cannabis sativa and non-cannabis phytomolecules
A Zagzoog, A Cabecinha, H Abramovici, RB Laprairie
Frontiers in Pharmacology 13, 956030, 2022
202022
The endocannabinoid system and synthetic cannabinoids in preclinical models of seizure and epilepsy
AM Smolyakova, A Zagzoog, AL Brandt, T Black, K Mohamed, ...
Journal of Clinical Neurophysiology 37 (1), 15-27, 2020
182020
Indomethacin enhances type 1 cannabinoid receptor signaling
RB Laprairie, KA Mohamed, A Zagzoog, MEM Kelly, LA Stevenson, ...
Frontiers in Molecular Neuroscience 12, 257, 2019
132019
Characterization of cannabinoid plasma concentration, maternal health, and cytokine levels in a rat model of prenatal Cannabis smoke exposure
T Black, SL Baccetto, IL Barnard, E Finch, DL McElroy, FVL Austin-Scott, ...
Scientific Reports 13 (1), 21070, 2023
122023
In vivo Evidence for Brain Region-Specific Molecular Interactions Between Cannabinoid and Orexin Receptors
HJJ Kim, A Zagzoog, AM Smolyakova, UC Ezeaka, MJ Benko, T Holt, ...
Frontiers in Neuroscience 15, 790546, 2021
112021
Dual cannabinoid and orexin regulation of anhedonic behaviour caused by prolonged restraint stress
HJJ Kim, A Zagzoog, C Ceni, R Ferrisi, N Janz, RB Laprairie
Brain sciences 13 (2), 314, 2023
102023
The effects of acute Cannabis smoke or Δ9-THC injections on the trial-unique, nonmatching-to-location and five-choice serial reaction time tasks in male Long-Evans rats
IL Barnard, TJ Onofrychuk, TM Sandini, DL McElroy, A Zagzoog, ...
Neurobiology of learning and memory 192, 107624, 2022
102022
Molecular and cellular mechanisms underlying brain region-specific endocannabinoid system modulation by estradiol across the rodent estrus cycle
HJJ Kim, A Zagzoog, T Black, SL Baccetto, RB Laprairie
Progress in Molecular Biology and Translational Science 195, 27-45, 2023
72023
The Intoxication Equivalency of 11-Hydroxy-Δ9-Tetrahydrocannabinol Relative to Δ9-Tetrahydrocannabinol
A Zagzoog, K Halter, AM Jones, N Bannatyne, J Cline, A Wilcox, ...
The Journal of Pharmacology and Experimental Therapeutics 391 (2), 194-205, 2024
42024
Pharmacological evaluation of enantiomerically separated positive allosteric modulators of cannabinoid 1 receptor, GAT591 and GAT593
AL Brandt, S Garai, A Zagzoog, DP Hurst, LA Stevenson, RG Pertwee, ...
Frontiers in Pharmacology 13, 919605, 2022
32022
Sex-specific differences in rotarod performance and type 1 cannabinoid receptor levels in a rat model of traumatic brain injury treated with Δ9-tetrahydrocannabinol
T Black, A Zagoog, AJ Roebuck, Q Greba, JP Neary, JG Howland, ...
bioRxiv, 2022.04. 11.487790, 2022
12022
Determination of the Negative Allosteric Binding Site of Cannabidiol at the CB1 Receptor: A Combined Computational and Site-Directed Mutagenesis Study
P Pandey, A Zagzoog, RB Laprairie, WM Neal, RJ Doerksen, ...
ACS Chemical Neuroscience, 2025
2025
Pharmacodynamics and Pharmacokinetics for Selected Cannabinoids
A Zagzoog
2024
Dual Cannabinoid and Orexin Regulation of Anhedonic Behaviour Caused by Prolonged Restraint Stress. Brain Sci. 2023, 13, 314
HJJ Kim, A Zagzoog, C Ceni, R Ferrisi, N Janz, RB Laprairie
2023
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