Tsuyoshi Shirai
Tsuyoshi Shirai
Nagahama Institute of Bioscience and Technology
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Aicardi-Goutieres syndrome is caused by IFIH1 mutations
H Oda, K Nakagawa, J Abe, T Awaya, M Funabiki, A Hijikata, ...
The American Journal of Human Genetics 95 (1), 121-125, 2014
High-resolution crystal structure of M-protease: phylogeny aided analysis of the high-alkaline adaptation mechanism.
T Shirai, A Suzuki, T Yamane, T Ashida, T Kobayashi, J Hitomi, S Ito
Protein engineering 10 (6), 627-634, 1997
Enzymatic properties, crystallization, and deduced amino acid sequence of an alkaline endoglucanase from Bacillus circulans
Y Hakamada, K Endo, S Takizawa, T Kobayashi, T Shirai, T Yamane, S Ito
Biochimica et Biophysica Acta (BBA)-General Subjects 1570 (3), 174-180, 2002
Identification of a High‐Frequency Somatic NLRC4 Mutation as a Cause of Autoinflammation by Pluripotent Cell–Based Phenotype Dissection
Y Kawasaki, H Oda, J Ito, A Niwa, T Tanaka, A Hijikata, R Seki, ...
Arthritis & rheumatology 69 (2), 447-459, 2017
Crystal structure of alkaline cellulase K: insight into the alkaline adaptation of an industrial enzyme
T Shirai, H Ishida, J Noda, T Yamane, K Ozaki, Y Hakamada, S Ito
Journal of molecular biology 310 (5), 1079-1087, 2001
The influence of PRNP polymorphisms on human prion disease susceptibility: an update
A Kobayashi, K Teruya, Y Matsuura, T Shirai, Y Nakamura, M Yamada, ...
Acta neuropathologica 130, 159-170, 2015
Mechanism of replication machinery assembly as revealed by the DNA ligase–PCNA–DNA complex architecture
K Mayanagi, S Kiyonari, M Saito, T Shirai, Y Ishino, K Morikawa
Proceedings of the National Academy of Sciences 106 (12), 4647-4652, 2009
Potential anti-COVID-19 agents, cepharanthine and nelfinavir, and their usage for combination treatment
H Ohashi, K Watashi, W Saso, K Shionoya, S Iwanami, T Hirokawa, ...
Iscience 24 (4), 102367, 2021
Multidrug treatment with nelfinavir and cepharanthine against COVID-19
H Ohashi, K Watashi, W Saso, K Shionoya, S Iwanami, T Hirokawa, ...
BioRxiv, 2020.04. 14.039925, 2020
Crystal structure of GH13 α‐glucosidase GSJ from one of the deepest sea bacteria
T Shirai, VS Hung, K Morinaka, T Kobayashi, S Ito
Proteins: Structure, Function, and Bioinformatics 73 (1), 126-133, 2008
Structural basis of the 3′‐end recognition of a leading strand in stalled replication forks by PriA
K Sasaki, T Ose, N Okamoto, K Maenaka, T Tanaka, H Masai, M Saito, ...
The EMBO Journal 26 (10), 2584-2593, 2007
Protein anatomy: functional roles of barnase module.
H Yanagawa, K Yoshida, C Torigoe, JS Park, K Sato, T Shirai, M Go
Journal of Biological Chemistry 268 (8), 5861-5865, 1993
Architecture of the DNA polymerase B-proliferating cell nuclear antigen (PCNA)-DNA ternary complex
K Mayanagi, S Kiyonari, H Nishida, M Saito, D Kohda, Y Ishino, T Shirai, ...
Proceedings of the National Academy of Sciences 108 (5), 1845-1849, 2011
High-resolution structure of the conger eel galectin, congerin I, in lactose-liganded and ligand-free forms: emergence of a new structure class by accelerated evolution
T Shirai, C Mitsuyama, Y Niwa, Y Matsui, H Hotta, T Yamane, H Kamiya, ...
Structure 7 (10), 1223-1233, 1999
An empirical approach for structure‐based prediction of carbohydrate‐binding sites on proteins
C Shionyu‐Mitsuyama, T Shirai, H Ishida, T Yamane
Protein Engineering 16 (7), 467-478, 2003
Identification of a mismatch-specific endonuclease in hyperthermophilic Archaea
S Ishino, Y Nishi, S Oda, T Uemori, T Sagara, N Takatsu, T Yamagami, ...
Nucleic acids research 44 (7), 2977-2986, 2016
Structure of rhamnose-binding lectin CSL3: unique pseudo-tetrameric architecture of a pattern recognition protein
T Shirai, Y Watanabe, M Lee, T Ogawa, K Muramoto
Journal of molecular biology 391 (2), 390-403, 2009
Crystal structure of a conger eel galectin (Congerin II) at 1.45 ┼ resolution: Implication for the accelerated evolution of a new ligand-binding site following gene duplication
T Shirai, Y Matsui, C Shionyu-Mitsuyama, T Yamane, H Kamiya, C Ishii, ...
Journal of molecular biology 321 (5), 879-889, 2002
Atomic structures and functional implications of the archaeal RecQ-like helicase Hjm
T Oyama, H Oka, K Mayanagi, T Shirai, K Matoba, R Fujikane, Y Ishino, ...
BMC Structural Biology 9, 1-12, 2009
Thermostabilization by replacement of specific residues with lysine in a Bacillus alkaline cellulase: building a structural model and implications of newly formedá…
T Ozawa, Y Hakamada, Y Hatada, T Kobayashi, T Shirai, S Ito
Protein Engineering 14 (7), 501-504, 2001
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