| The activity of alkyl phosphorylcholines and related derivatives against Leishmania donovani SL Croft, RA Neal, W Pendergast, JH Chan Biochemical pharmacology 36 (16), 2633-2636, 1987 | 314 | 1987 |
| Structure− activity relationship studies of novel benzophenones leading to the discovery of a potent, next generation HIV nonnucleoside reverse transcriptase inhibitor KR Romines, GA Freeman, LT Schaller, JR Cowan, SS Gonzales, ... Journal of medicinal chemistry 49 (2), 727-739, 2006 | 198 | 2006 |
| Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1. AL Hopkins, J Ren, J Milton, RJ Hazen, JH Chan, DI Stuart, DK Stammers Journal of medicinal chemistry 47 (24), 5912-5922, 2004 | 120 | 2004 |
| Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2. GA Freeman, CW Andrews, AL Hopkins, GS Lowell, LT Schaller, ... Journal of medicinal chemistry 47 (24), 5923-5936, 2004 | 104 | 2004 |
| 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1 JH Chan, JS Hong, RN Hunter, GF Orr, JR Cowan, DB Sherman, ... Journal of Medicinal Chemistry 44 (12), 1866-1882, 2001 | 104 | 2001 |
| Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors J Ren, PP Chamberlain, A Stamp, SA Short, KL Weaver, KR Romines, ... Journal of medicinal chemistry 51 (16), 5000-5008, 2008 | 103 | 2008 |
| Novel benzophenones as non-nucleoside reverse transcriptase inhibitors of HIV-1 JH Chan, GA Freeman, JH Tidwell, KR Romines, LT Schaller, JR Cowan, ... Journal of medicinal chemistry 47 (5), 1175-1182, 2004 | 99 | 2004 |
| Selective inhibitors of Candida albicans dihydrofolate reductase: activity and selectivity of 5-(arylthio)-2, 4-diaminoquinazolines JH Chan, JS Hong, LF Kuyper, DP Baccanari, SS Joyner, RL Tansik, ... Journal of medicinal chemistry 38 (18), 3608-3616, 1995 | 93 | 1995 |
| Antiviral activity of GW678248, a novel benzophenone nonnucleoside reverse transcriptase inhibitor RG Ferris, RJ Hazen, GB Roberts, MH St. Clair, JH Chan, KR Romines, ... Antimicrobial agents and chemotherapy 49 (10), 4046-4051, 2005 | 83 | 2005 |
| Relationship of potency and resilience to drug resistant mutations for GW420867X revealed by crystal structures of inhibitor complexes for wild-type, Leu100Ile, Lys101Glu, and … J Ren, CE Nichols, PP Chamberlain, KL Weaver, SA Short, JH Chan, ... Journal of medicinal chemistry 50 (10), 2301-2309, 2007 | 70 | 2007 |
| Synthesis of 1,3‐diamino‐7,8,9,10‐tetrahydropyrido[3,2‐f]‐quinazolines. Inhibitors of Candida albicans dihydrofolate reductase as potential antifungal agents JH Chan, DP Baccanari, RL Tansik, CM Boytos, SK Rudolph, AD Brown, ... Journal of heterocyclic chemistry 34 (1), 145-151, 1997 | 55 | 1997 |
| X-ray Crystal Structures of Candida albicans Dihydrofolate Reductase: High Resolution Ternary Complexes in Which the Dihydronicotinamide Moiety of NADPH … M Whitlow, AJ Howard, D Stewart, KD Hardman, JH Chan, DP Baccanari, ... Journal of medicinal chemistry 44 (18), 2928-2932, 2001 | 48 | 2001 |
| Anti-human immunodeficiency virus type 1 activity of the nonnucleoside reverse transcriptase inhibitor GW678248 in combination with other antiretrovirals against clinical … RJ Hazen, RJ Harvey, MH St. Clair, RG Ferris, GA Freeman, JH Tidwell, ... Antimicrobial agents and chemotherapy 49 (11), 4465-4473, 2005 | 37 | 2005 |
| Synthesis of 5‐(4‐substituted benzyl)‐2,4‐diaminoquinazolines as inhibitors of candida albicans dihydrofolate reductase GE Jagdmann Jr, JH Chan, VL Styles, RL Tansik, CM Boytos, SK Rudolph Journal of heterocyclic chemistry 32 (5), 1461-1465, 1995 | 36 | 1995 |
| 2, 4-Diamino-5-benzylpyrimidines and analogs as antibacterial agents. 11. Quinolylmethyl analogs with basic substituents conveying specificity SE Davis, BS Rauckman, JH Chan, B Roth Journal of medicinal chemistry 32 (8), 1936-1942, 1989 | 31 | 1989 |
| 2, 4-Diamino-5-benzylpyrimidines as antibacterial agents. 14. 2, 3-Dihydro-1-(2, 4-diamino-5-pyrimidyl)-1H-indenes as conformationally restricted analogs of trimethoprim JH Chan, B Roth Journal of medicinal chemistry 34 (2), 550-555, 1991 | 27 | 1991 |
| N-Hydroxyformamide peptidomimetics as TACE/matrix metalloprotease inhibitors: oral activity via P1′ isobutyl substitution DL Musso, MW Andersen, RC Andrews, R Austin, EJ Beaudet, ... Bioorganic & medicinal chemistry letters 11 (16), 2147-2151, 2001 | 25 | 2001 |
| 1, 4-Bis (5-(naphthalen-1-yl) thiophen-2-yl) naphthalene, a small molecule, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular … W Gu, DTM Ip, S Liu, JH Chan, Y Wang, X Zhang, Y Zheng, DCC Wan Chemico-biological interactions 213, 21-27, 2014 | 17 | 2014 |
| Synthesis and evaluation of a series of 2′-deoxy analogues of the antiviral agent 5, 6-dichloro-2-isopropylamino-1-(β-l-ribofuranosyl)-1H-benzimidazole (1263W94) JH Chan, SD Chamberlain, KK Biron, MG Davis, RJ Harvey, ... Nucleosides, Nucleotides & Nucleic Acids 19 (1-2), 101-123, 2000 | 17 | 2000 |
| Benzophenones as inhibitors of reverse transcriptase JH Chan US Patent 6,995,283, 2006 | 7 | 2006 |
