| Skin-derived precursors generate myelinating Schwann cells that promote remyelination and functional recovery after contusion spinal cord injury J Biernaskie, JS Sparling, J Liu, CP Shannon, JR Plemel, Y Xie, FD Miller, ... Journal of Neuroscience 27 (36), 9545-9559, 2007 | 403 | 2007 |
| Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin MA Pouladi, RK Graham, JM Karasinska, Y Xie, RD Santos, Å Petersén, ... Brain 132 (4), 919-932, 2009 | 180 | 2009 |
| Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 mice MA Pouladi, LM Stanek, Y Xie, S Franciosi, AL Southwell, Y Deng, ... Human molecular genetics 21 (10), 2219-2232, 2012 | 172 | 2012 |
| In vivo evaluation of candidate allele-specific mutant huntingtin gene silencing antisense oligonucleotides AL Southwell, NH Skotte, HB Kordasiewicz, ME Østergaard, AT Watt, ... Molecular Therapy 22 (12), 2093-2106, 2014 | 151 | 2014 |
| A mouse atlas of gene expression: large-scale digital gene-expression profiles from precisely defined developing C57BL/6J mouse tissues and cells AS Siddiqui, J Khattra, AD Delaney, Y Zhao, C Astell, J Asano, ... Proceedings of the National Academy of Sciences 102 (51), 18485-18490, 2005 | 143 | 2005 |
| Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression MA Pouladi, Y Xie, NH Skotte, DE Ehrnhoefer, RK Graham, JE Kim, ... Human molecular genetics 19 (8), 1528-1538, 2010 | 139 | 2010 |
| Visualization of corticofugal projections during early cortical development in a τ‐GFP‐transgenic mouse EC Jacobs, C Campagnoni, K Kampf, SD Reyes, V Kalra, V Handley, ... European Journal of Neuroscience 25 (1), 17-30, 2007 | 130 | 2007 |
| GDNF and BDNF alter the expression of neuronal NOS, c-Jun, and p75 and prevent motoneuron death following spinal root avulsion in adult rats W Wu, L Li, LW Yick, H Chai, Y Xie, Y Yang, DM Prevette, RW Oppenheim Journal of neurotrauma 20 (6), 603-612, 2003 | 127 | 2003 |
| A fully humanized transgenic mouse model of Huntington disease AL Southwell, SC Warby, JB Carroll, CN Doty, NH Skotte, W Zhang, ... Human molecular genetics 22 (1), 18-34, 2013 | 124 | 2013 |
| Altered adult hippocampal neurogenesis in the YAC128 transgenic mouse model of Huntington disease JM Simpson, J Gil-Mohapel, MA Pouladi, M Ghilan, Y Xie, MR Hayden, ... Neurobiology of disease 41 (2), 249-260, 2011 | 113 | 2011 |
| Huntingtin suppression restores cognitive function in a mouse model of Huntington’s disease AL Southwell, HB Kordasiewicz, D Langbehn, NH Skotte, MP Parsons, ... Science translational medicine 10 (461), eaar3959, 2018 | 109 | 2018 |
| Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain huntingtin suppression AL Southwell, SEP Smith, TR Davis, NS Caron, EB Villanueva, Y Xie, ... Scientific reports 5 (1), 12166, 2015 | 108 | 2015 |
| An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes AL Southwell, A Smith-Dijak, C Kay, M Sepers, EB Villanueva, ... Human molecular genetics 25 (17), 3654-3675, 2016 | 105 | 2016 |
| Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease AL Southwell, S Franciosi, EB Villanueva, Y Xie, LA Winter, ... Neurobiology of disease 76, 46-56, 2015 | 101 | 2015 |
| Structural and molecular myelination deficits occur prior to neuronal loss in the YAC128 and BACHD models of Huntington disease RTY Teo, X Hong, L Yu-Taeger, Y Huang, LJ Tan, Y Xie, XV To, L Guo, ... Human molecular genetics 25 (13), 2621-2632, 2016 | 99 | 2016 |
| Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice V Uribe, BKY Wong, RK Graham, CL Cusack, NH Skotte, MA Pouladi, ... Human molecular genetics 21 (9), 1954-1967, 2012 | 75 | 2012 |
| Potent and sustained huntingtin lowering via AAV5 encoding miRNA preserves striatal volume and cognitive function in a humanized mouse model of Huntington disease NS Caron, AL Southwell, CC Brouwers, LD Cengio, Y Xie, HF Black, ... Nucleic acids research 48 (1), 36-54, 2020 | 62 | 2020 |
| NP03, a novel low-dose lithium formulation, is neuroprotective in the YAC128 mouse model of Huntington disease MA Pouladi, E Brillaud, Y Xie, P Conforti, RK Graham, DE Ehrnhoefer, ... Neurobiology of disease 48 (3), 282-289, 2012 | 52 | 2012 |
| Mutant huntingtin is cleared from the brain via active mechanisms in Huntington disease NS Caron, R Banos, C Yanick, AE Aly, LM Byrne, ED Smith, Y Xie, ... Journal of Neuroscience 41 (4), 780-796, 2021 | 47 | 2021 |
| Delayed implantation of a peripheral nerve graft reduces motoneuron survival but does not affect regeneration following spinal root avulsion in adult rats W Wu, H Chai, J Zhang, H Gu, Y Xie, L Zhou Journal of neurotrauma 21 (8), 1050-1058, 2004 | 47 | 2004 |
Michael HaydenKillam Professor, University of British ColumbiaVerified email at cmmt.ubc.ca
