Multiplex genome engineering using CRISPR/Cas systems L Cong, FA Ran, D Cox, S Lin, R Barretto, N Habib, PD Hsu, X Wu, ... Science 339 (6121), 819-823, 2013 | 18873 | 2013 |
Genome engineering using the CRISPR-Cas9 system FA Ran, PD Hsu, J Wright, V Agarwala, DA Scott, F Zhang Nature protocols 8 (11), 2281-2308, 2013 | 12657 | 2013 |
DNA targeting specificity of RNA-guided Cas9 nucleases PD Hsu, DA Scott, JA Weinstein, FA Ran, S Konermann, V Agarwala, Y Li, ... Nature biotechnology 31 (9), 827-832, 2013 | 5644 | 2013 |
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity FA Ran, PD Hsu, CY Lin, JS Gootenberg, S Konermann, AE Trevino, ... Cell 154 (6), 1380-1389, 2013 | 4340 | 2013 |
In vivo genome editing using Staphylococcus aureus Cas9 FA Ran, L Cong, WX Yan, DA Scott, JS Gootenberg, AJ Kriz, B Zetsche, ... Nature 520 (7546), 186-191, 2015 | 3151 | 2015 |
Crystal structure of Cas9 in complex with guide RNA and target DNA H Nishimasu, FA Ran, PD Hsu, S Konermann, SI Shehata, N Dohmae, ... Cell 156 (5), 935-949, 2014 | 2487 | 2014 |
In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy CE Nelson, CH Hakim, DG Ousterout, PI Thakore, EA Moreb, RMC Rivera, ... Science 351 (6271), 403-407, 2016 | 1377 | 2016 |
In vivo gene editing in dystrophic mouse muscle and muscle stem cells M Tabebordbar, K Zhu, JKW Cheng, WL Chew, JJ Widrick, WX Yan, ... Science 351 (6271), 407-411, 2016 | 1247 | 2016 |
CRISPR-Cas nickase systems, methods and compositions for sequence manipulation in eukaryotes L Cong, F Zhang US Patent 8,932,814, 2015 | 571 | 2015 |
Crystal structure of Staphylococcus aureus Cas9 H Nishimasu, L Cong, WX Yan, FA Ran, B Zetsche, Y Li, A Kurabayashi, ... Cell 162 (5), 1113-1126, 2015 | 509 | 2015 |
Common genetic variants modulate pathogen-sensing responses in human dendritic cells MN Lee, C Ye, AC Villani, T Raj, W Li, TM Eisenhaure, SH Imboywa, ... Science 343 (6175), 1246980, 2014 | 497 | 2014 |
Crystal structure of the minimal Cas9 from Campylobacter jejuni reveals the molecular diversity in the CRISPR-Cas9 systems M Yamada, Y Watanabe, JS Gootenberg, H Hirano, FA Ran, T Nakane, ... Molecular cell 65 (6), 1109-1121. e3, 2017 | 190 | 2017 |
RNA-guided genome editing of mammalian cells NK Pyzocha, FA Ran, PD Hsu, F Zhang Gene Correction: Methods and Protocols, 269-277, 2014 | 64 | 2014 |
.(2013) DNA targeting specificity of RNA-guided Cas9 nucleases PD Hsu, DA Scott, JA Weinstein, FA Ran, S Konermann, V Agarwala, Y Li, ... Nat. Biotechnol 31, 827-832, 0 | 51 | |
In Vivo Genome Engineering With AAV Vector Carrying CRISPR-Cas9 System L Cong, WX Yan, F Ran, B Zetsche, F Zhang Molecular Therapy 22, S214-S214, 2014 | 20 | 2014 |
Adaptation of CRISPR nucleases for eukaryotic applications FA Ran Analytical biochemistry 532, 90-94, 2017 | 13 | 2017 |
CRISPR-Cas: Development and applications for mammalian genome editing FA Ran Harvard University, 2014 | 11 | 2014 |
482. Local and Systemic Gene Editing in a Mouse Model of Duchenne Muscular Dystrophy C Nelson, M Gemberling, CH Hakim, DG Ousterout, PI Thakore, ... Molecular Therapy 24, S191, 2016 | 2 | 2016 |
CRISPR/Cas9: tools and applications for eukaryotic genome editing FA Ran NABC, 2014 | 2 | 2014 |
Protocol Exchange E Owusu-Ansah, A Yavari, U Banerjee DOI, 2008 | 2 | 2008 |