| An unexpected synergist role of P-glycoprotein and breast cancer resistance protein on the central nervous system penetration of the tyrosine kinase inhibitor lapatinib (N-{3 … JW Polli, KL Olson, JP Chism, LS John-Williams, RL Yeager, ... Drug Metabolism and Disposition 37 (2), 439-442, 2009 | 313 | 2009 |
| MALDI imaging mass spectrometry: bridging biology and chemistry in drug development S Castellino, MR Groseclose, D Wagner Bioanalysis 3 (21), 2427-2441, 2011 | 257 | 2011 |
| The role of efflux and uptake transporters in N-{3-chloro-4-[(3-fluorobenzyl) oxy] phenyl}-6-[5-({[2-(methylsulfonyl) ethyl] amino} methyl)-2-furyl]-4-quinazolinamine (GW572016 … JW Polli, JE Humphreys, KA Harmon, S Castellino, MJ O'mara, KL Olson, ... Drug metabolism and disposition 36 (4), 695-701, 2008 | 240 | 2008 |
| Lapatinib distribution in HER2 overexpressing experimental brain metastases of breast cancer KS Taskar, V Rudraraju, RK Mittapalli, R Samala, HR Thorsheim, ... Pharmaceutical research 29, 770-781, 2012 | 231 | 2012 |
| A mimetic tissue model for the quantification of drug distributions by MALDI imaging mass spectrometry MR Groseclose, S Castellino Analytical chemistry 85 (21), 10099-10106, 2013 | 224 | 2013 |
| Metabolism, excretion, and mass balance of the HIV-1 integrase inhibitor dolutegravir in humans S Castellino, L Moss, D Wagner, J Borland, I Song, S Chen, Y Lou, ... Antimicrobial agents and chemotherapy 57 (8), 3536-3546, 2013 | 201 | 2013 |
| On the origins of stereoselectivity in chelation controlled nucleophilic additions to. beta.-alkoxy aldehydes: solution structures of Lewis acid complexes via NMR spectroscopy GE Keck, S Castellino Journal of the American Chemical Society 108 (13), 3847-3849, 1986 | 159 | 1986 |
| Synthesis and characterization of two aromatic silicon-containing dianions: the 2, 3, 4, 5-tetraphenylsilole dianion and the 1, 1'-disila-2, 2', 3, 3', 4, 4', 5, 5 … JH Hong, P Boudjouk, S Castellino Organometallics 13 (9), 3387-3389, 1994 | 146 | 1994 |
| Direct evidence for the absence of chelation with β-silyloxy aldehydes and Lewis acids GE Keck, S Castellino Tetrahedron letters 28 (3), 281-284, 1987 | 141 | 1987 |
| Diethylaluminum chloride complexes of an N-acyloxazolidinone: NMR investigation S Castellino, WJ Dwight Journal of the American Chemical Society 115 (7), 2986-2987, 1993 | 128 | 1993 |
| Human metabolism of lapatinib, a dual kinase inhibitor: implications for hepatotoxicity S Castellino, M O'Mara, K Koch, DJ Borts, GD Bowers, C MacLauchlin Drug Metabolism and Disposition 40 (1), 139-150, 2012 | 115 | 2012 |
| Dramatic effects of oxygen substituents on 1, 3-asymmetric induction in additions of allyltriphenylstannane to. beta.-alkoxy aldehydes: a chemical and spectroscopic investigation GE Keck, S Castellino, MR Wiley The Journal of Organic Chemistry 51 (26), 5478-5480, 1986 | 106 | 1986 |
| The mechanism of tin tetrachloride promoted additions of allylstannanes to aldehydes: a response to Denmark, Wilson, and Willson GE Keck, MB Andrus, S Castellino Journal of the American Chemical Society 111 (21), 8136-8141, 1989 | 85 | 1989 |
| HER2-overexpressing breast cancers amplify FGFR signaling upon acquisition of resistance to dual therapeutic blockade of HER2 AB Hanker, JT Garrett, MV Estrada, PD Moore, PG Ericsson, JP Koch, ... Clinical Cancer Research 23 (15), 4323-4334, 2017 | 82 | 2017 |
| Central nervous system disposition and metabolism of fosdevirine (GSK2248761), a non-nucleoside reverse transcriptase inhibitor: an LC-MS and matrix-assisted laser desorption … S Castellino, MR Groseclose, J Sigafoos, D Wagner, M de Serres, ... Chemical research in toxicology 26 (2), 241-251, 2013 | 81 | 2013 |
| Tin tetrachloride chelation of an N-acyloxazolidinone: an NMR investigation S Castellino The Journal of Organic Chemistry 55 (18), 5197-5200, 1990 | 60 | 1990 |
| Assessing drug and metabolite detection in liver tissue by UV-MALDI and IR-MALDESI mass spectrometry imaging coupled to FT-ICR MS JA Barry, MR Groseclose, G Robichaud, S Castellino, DC Muddiman International journal of mass spectrometry 377, 448-455, 2015 | 58 | 2015 |
| Multicenter validation study of quantitative imaging mass spectrometry JA Barry, R Ait-Belkacem, WM Hardesty, L Benakli, C Andonian, ... Analytical chemistry 91 (9), 6266-6274, 2019 | 56 | 2019 |
| Imaging MS in toxicology: an investigation of juvenile rat nephrotoxicity associated with dabrafenib administration MR Groseclose, SB Laffan, KS Frazier, A Hughes-Earle, S Castellino Journal of the american society for mass spectrometry 26 (6), 887-898, 2015 | 56 | 2015 |
| Quantification and assessment of detection capability in imaging mass spectrometry using a revised mimetic tissue model JA Barry, MR Groseclose, S Castellino Bioanalysis 11 (11), 1099-1116, 2019 | 53 | 2019 |
