| Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors J Brem, T Panduwawala, JU Hansen, J Hewitt, E Liepins, P Donets, ... Nature Chemistry 14 (1), 15-24, 2022 | 45 | 2022 |
| Profiling interactions of vaborbactam with metallo-β-lactamases GW Langley, R Cain, JM Tyrrell, P Hinchliffe, K Calvopiña, CL Tooke, ... Bioorganic & medicinal chemistry letters 29 (15), 1981-1984, 2019 | 42 | 2019 |
| In vitro efficacy of imipenem-relebactam and cefepime-AAI101 against a global collection of ESBL-positive and carbapenemase-producing Enterobacteriaceae L Tselepis, GW Langley, AF Aboklaish, E Widlake, DE Jackson, TR Walsh, ... International journal of antimicrobial agents 56 (1), 105925, 2020 | 41 | 2020 |
| Targeting the Mycobacterium tuberculosis transpeptidase Ldt Mt2 with cysteine-reactive inhibitors including ebselen M de Munnik, CT Lohans, PA Lang, GW Langley, TR Malla, A Tumber, ... Chemical Communications 55 (69), 10214-10217, 2019 | 28 | 2019 |
| Structure‐Activity Relationship and Crystallographic Studies on 4‐Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors JP Holt‐Martyn, R Chowdhury, A Tumber, TL Yeh, MI Abboud, K Lippl, ... ChemMedChem 15 (3), 270-273, 2020 | 25 | 2020 |
| Broad spectrum β-lactamase inhibition by a thioether substituted bicyclic boronate A Parkova, A Lucic, A Krajnc, J Brem, K Calvopina, GW Langley, ... ACS Infectious Diseases 6 (6), 1398-1404, 2019 | 20 | 2019 |
| Analysis of JmjC demethylase-catalyzed demethylation using geometrically-constrained lysine analogues GW Langley, A Brinkø, M Münzel, LJ Walport, CJ Schofield, ... ACS chemical biology 11 (3), 755-762, 2016 | 19 | 2016 |
| A Fluorescence‐Based Assay for Screening β‐Lactams Targeting the Mycobacterium tuberculosis Transpeptidase LdtMt2 M de Munnik, CT Lohans, GW Langley, C Bon, J Brem, CJ Schofield ChemBioChem 21 (3), 368-372, 2020 | 15 | 2020 |
| Inhibition of a viral prolyl hydroxylase GW Langley, MI Abboud, CT Lohans, CJ Schofield Bioorganic & medicinal chemistry 27 (12), 2405-2412, 2019 | 7 | 2019 |
| Human histone demethylase KDM6B can catalyse sequential oxidations RJ Hopkinson, GW Langley, R Belle, LJ Walport, K Dunne, M Münzel, ... Chemical Communications 54 (57), 7975-7978, 2018 | 4 | 2018 |
| Pharmacological inhibition of PMS2 increases tumor mutational burden, induces microsatellite instability and elicits immune mediated rejection in vivo E Piumatti, A Hervieu, P Riou, J Blagg, A Peall, S Weeks, ... Cancer Research 84 (6_Supplement), 6011-6011, 2024 | | 2024 |
| NP1867, a potent, selective, covalent small molecule inhibitor of DNA Mismatch Repair (MMR) protein PMS2, functionally inhibits MMR in cells and elicits COSMIC mutational … J Blagg, P Riou, A Hervieu, E Piumatti, G Rospo, S Arunachalam, B Meier, ... MOLECULAR CANCER THERAPEUTICS 22 (12), 2023 | | 2023 |
| Isoindoline Derivatives Which Bind to an ATP Binding Site J Blagg, JRA Roffey, PCM Winship, GW Langley WO Patent WO/2021/148,786, 2021 | | 2021 |
| Probing the Charge and Conformational Requirements of JmjC Demethylases GW Langley, A Brinkø, M Münzel, LJ Walport, CJ Schofield, RJ Hopkinson The FASEB Journal 31, 767.1-767.1, 2017 | | 2017 |
| Studies on collagen post-translational modifications GW Langley University of Oxford, 2017 | | 2017 |
Christopher LohansAssistant Professor, Queen's UniversityVerified email at queensu.ca
