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Michael C. Yoon, PhD
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Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders
V Hook, M Yoon, C Mosier, G Ito, S Podvin, BP Head, R Rissman, ...
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1868 (8), 140428, 2020
1022020
A clinical-stage cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells
DM Mellott, CT Tseng, A Drelich, P Fajtová, BC Chenna, DH Kostomiris, ...
ACS chemical biology 16 (4), 642-650, 2021
932021
Untargeted mass spectrometry-based metabolomics approach unveils molecular changes in raw and processed foods and beverages
JM Gauglitz, CM Aceves, AA Aksenov, G Aleti, J Almaliti, A Bouslimani, ...
Food chemistry 302, 125290, 2020
572020
Potent anti-SARS-CoV-2 activity by the natural product gallinamide A and analogues via inhibition of cathepsin L
AS Ashhurst, AH Tang, P Fajtová, MC Yoon, A Aggarwal, MJ Bedding, ...
Journal of medicinal chemistry 65 (4), 2956-2970, 2021
482021
Selective neutral pH inhibitor of cathepsin B designed based on cleavage preferences at cytosolic and lysosomal pH conditions
MC Yoon, A Solania, Z Jiang, MP Christy, S Podvin, C Mosier, CB Lietz, ...
ACS chemical biology 16 (9), 1628-1643, 2021
332021
Differential neuropeptidomes of dense core secretory vesicles (DCSV) produced at intravesicular and extracellular pH conditions by proteolytic processing
Z Jiang, CB Lietz, S Podvin, MC Yoon, T Toneff, V Hook, AJ O’Donoghue
ACS chemical neuroscience 12 (13), 2385-2398, 2021
162021
Molecular features of CA-074 pH-dependent inhibition of Cathepsin B
MC Yoon, MP Christy, VV Phan, WH Gerwick, G Hook, AJ O’Donoghue, ...
Biochemistry 61 (4), 228-238, 2022
152022
Cathepsin B dipeptidyl carboxypeptidase and endopeptidase activities demonstrated across a broad pH range
MC Yoon, V Hook, AJ O’Donoghue
Biochemistry 61 (17), 1904-1914, 2022
122022
Potent in vitro anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L
AS Ashhurst, AH Tang, P Fajtová, M Yoon, A Aggarwal, A Stoye, ...
bioRxiv, 2020.12. 23.424111, 2020
112020
Distinct dibasic cleavage specificities of neuropeptide-producing cathepsin L and cathepsin V cysteine proteases compared to PC1/3 and PC2 serine proteases
MC Yoon, J Ames, C Mosier, Z Jiang, S Podvin, AJ O’Donoghue, V Hook
ACS chemical neuroscience 13 (2), 245-256, 2022
82022
Discovery of pH-Selective Marine and Plant Natural Product Inhibitors of Cathepsin B Revealed by Screening at Acidic and Neutral pH Conditions
VV Phan, C Mosier, MC Yoon, E Glukhov, CR Caffrey, AJ O’Donoghue, ...
ACS omega 7 (29), 25346-25352, 2022
22022
Distinct cleavage properties of cathepsin B compared to cysteine cathepsins enable the design and validation of a specific substrate for cathepsin B over a broad pH range
MC Yoon, V Phan, S Podvin, C Mosier, AJ O’Donoghue, V Hook
Biochemistry 62 (15), 2289-2300, 2023
12023
Orthogonal Deprotection Strategy of Fmoc Provides Improved Synthesis of Sensitive Peptides: Application to Z-Arg-Lys-AOMK
J Almaliti, M Alhindy, MC Yoon, V Hook, TF Molinski, AJ O’Donoghue, ...
ACS omega 9 (3), 3997-4003, 2024
2024
Virtual screening and drug repurposing: together against worm-borne diseases
D Rando, R Cogo, J Moraes, M Yoon, Y Sun, D Amarasinghe, C Caffrey, ...
MDPI, 2022
2022
Discovery of pH-Dependent Protease Cleavage Properties Leads to the Rational Design of Neutral pH-Selective Inhibitor of Cathepsin B Involved in Human Diseases
MC Yoon
UC San Diego, 2022
2022
Assessing the Acceptance of the Pay-For-Performance Model in a Segment of California Pharmacists
J Colbert, S McBane, MS Lam, A Blaj, B Zimmers, M Yoon, B Park, T Le, ...
Journal of Contemporary Pharmacy Practice 65 (3), 37-42, 2018
2018
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Articles 1–16