| Remarkably Stable (Me3Al)2⋅DABCO and Stereoselective Nickel‐Catalyzed AlR3 (R=Me, Et) Additions to Aldehydes K Biswas, O Prieto, PJ Goldsmith, S Woodward Angewandte Chemie International Edition 44 (15), 2232-2234, 2005 | 158 | 2005 |
| Rational design of phosphoinositide 3-kinase α inhibitors that exhibit selectivity over the phosphoinositide 3-kinase β isoform TP Heffron, BQ Wei, A Olivero, ST Staben, V Tsui, S Do, J Dotson, ... Journal of medicinal chemistry 54 (22), 7815-7833, 2011 | 81 | 2011 |
| Current status of muscarinic M1 and M4 receptors as drug targets for neurodegenerative diseases CC Felder, PJ Goldsmith, K Jackson, HE Sanger, DA Evans, AJ Mogg, ... Neuropharmacology 136, 449-458, 2018 | 77 | 2018 |
| Discovery of novel PI3-kinase δ specific inhibitors for the treatment of rheumatoid arthritis: taming CYP3A4 time-dependent inhibition BS Safina, S Baker, M Baumgardner, PM Blaney, BK Chan, YH Chen, ... Journal of medicinal chemistry 55 (12), 5887-5900, 2012 | 72 | 2012 |
| Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a … JA Monn, L Prieto, L Taboada, C Pedregal, J Hao, MR Reinhard, ... Journal of medicinal chemistry 58 (4), 1776-1794, 2015 | 65 | 2015 |
| Benzopyran and benzoxepin PI3K inhibitor compounds and methods of use S Do, R Goldsmith, T Heffron, A Kolesnikov, S Staben, AG Olivero, M Siu, ... US Patent 7,928,248, 2011 | 65 | 2011 |
| Potent and selective inhibitors of PI3Kδ: Obtaining isoform selectivity from the affinity pocket and tryptophan shelf DP Sutherlin, S Baker, A Bisconte, PM Blaney, A Brown, BK Chan, ... Bioorganic & medicinal chemistry letters 22 (13), 4296-4302, 2012 | 62 | 2012 |
| Enantioselective Preparation of β, β‐Disubstituted α‐Methylenepropionates by MAO Promotion of the Zinc Schlenk Equilibrium PJ Goldsmith, SJ Teat, S Woodward Angewandte Chemie International Edition 44 (15), 2235-2237, 2005 | 61 | 2005 |
| Asymmetric chemo-and regiospecific addition of organozinc reagents to Baylis–Hillman derived allylic electrophiles C Börner, J Gimeno, S Gladiali, PJ Goldsmith, D Ramazzotti, S Woodward Chemical Communications, 2433-2434, 2000 | 31 | 2000 |
| Abstract DDT02-01: Discovery of GDC-0032: A beta-sparing PI3K inhibitor active against PIK3CA mutant tumors. AG Olivero, TP Heffron, M Baumgardner, M Belvin, LB Ross, N Blaquiere, ... Cancer Research 73 (8_Supplement), DDT02-01-DDT02-01, 2013 | 24 | 2013 |
| Expedient synthesis of β, β-disubstituted α-methylenepropionates K Biswas, C Börner, J Gimeno, PJ Goldsmith, D Ramazzotti, ALK So, ... Tetrahedron 61 (6), 1433-1442, 2005 | 21 | 2005 |
| Substituted thieno-and furano-fused pyrimidines as PI3K inhibitors IS Chuckowree, AJ Folkes, P Goldsmith, TC Hancox, SJ Shuttleworth US Patent 8,153,639, 2012 | 15 | 2012 |
| Identification and pharmacological profile of SPP1, a potent, functionally selective and brain penetrant agonist at muscarinic M1 receptors LM Broad, HE Sanger, AJ Mogg, EM Colvin, R Zwart, DA Evans, F Pasqui, ... British Journal of Pharmacology 176 (1), 110-126, 2019 | 12 | 2019 |
| In vitro pharmacological characterization and in vivo validation of LSN3172176 a novel M1 selective muscarinic receptor agonist tracer molecule for positron emission tomography AJ Mogg, T Eessalu, M Johnson, R Wright, HE Sanger, H Xiao, ... Journal of Pharmacology and Experimental Therapeutics 365 (3), 602-613, 2018 | 12 | 2018 |
| NMDAR PAMs: Multiple Chemotypes for Multiple Binding Sites P Goldsmith Current Topics in Medicinal Chemistry 19 (24), 2239-2253, 2019 | 10 | 2019 |
| Fused pyridines active as inhibitors of c-met AJ Folkes, P Goldsmith, NA Pegg US Patent App. 12/864,112, 2011 | 9 | 2011 |
| Purine derivatives useful as p13 kinase inhibitors P Goldsmith, TC Hancox, NA Pegg, JJ Kulagowski, AJ Nadin, S Price US Patent App. 12/739,437, 2011 | 8 | 2011 |
| 4, 5-dihydro-6-oxa-3-thia-1-aza-benzo [e] azulene compounds S Do, R Goldsmith, T Heffron, A Kolesnikov, S Staben, AG Olivero, M Siu, ... US Patent 8,399,690, 2013 | 7 | 2013 |
| Discovery of two novel, selective agonist radioligands as PET imaging agents for the M1 muscarinic acetylcholine receptor C Jesudason, V Barth, P Goldsmith, K Ruley, M Johnson, A Mogg, ... Journal of Nuclear Medicine 58 (supplement 1), 546-546, 2017 | 6 | 2017 |
| Pharmaceutical compounds SJ Baker, PJ Goldsmith, TC Hancox, NA Pegg, SJ Shuttleworth, ... US Patent App. 12/594,543, 2010 | 6 | 2010 |
