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Yulei Zhang
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Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space
EK Makowski, PC Kinnunen, J Huang, L Wu, MD Smith, T Wang, ...
Nature communications 13 (1), 3788, 2022
692022
Net charge of antibody complementarity-determining regions is a key predictor of specificity
LA Rabia, Y Zhang, SD Ludwig, MC Julian, PM Tessier
Protein Engineering, Design and Selection 31 (11), 409-418, 2018
642018
Physicochemical rules for identifying monoclonal antibodies with drug-like specificity
Y Zhang, L Wu, P Gupta, AA Desai, MD Smith, LA Rabia, SD Ludwig, ...
Molecular pharmaceutics 17 (7), 2555-2569, 2020
432020
Dual-ligand zeolitic imidazolate framework crystals and oriented films derived from metastable mono-ligand ZIF-108
Y Ban, Y Peng, Y Zhang, H Jin, W Jiao, A Guo, P Wang, Y Li, W Yang
Microporous and Mesoporous Materials 219, 190-198, 2016
232016
Rational affinity maturation of anti-amyloid antibodies with high conformational and sequence specificity
AA Desai, MD Smith, Y Zhang, EK Makowski, JE Gerson, E Ionescu, ...
Journal of Biological Chemistry 296, 2021
222021
Antibodies with Weakly Basic Isoelectric Points Minimize Trade-offs between Formulation and Physiological Colloidal Properties
P Gupta, EK Makowski, S Kumar, Y Zhang, JM Scheer, PM Tessier
Mol. Pharmaceutics 19 (3), 775–787, 2022
192022
Directed evolution of conformation‐specific antibodies for sensitive detection of polypeptide aggregates in therapeutic drug formulations
W Lou, SD Stimple, AA Desai, EK Makowski, S Kalyoncu, JE Mogensen, ...
Biotechnology and Bioengineering 118 (2), 797-808, 2021
32021
Janus particle rotator-to-lamellar nucleation and growth kinetics
DJ Beltran-Villegas, Y Zhang, RG Larson
The Journal of Chemical Physics 146 (9), 2017
22017
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Articles 1–8