Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space EK Makowski, PC Kinnunen, J Huang, L Wu, MD Smith, T Wang, ... Nature communications 13 (1), 3788, 2022 | 69 | 2022 |
Net charge of antibody complementarity-determining regions is a key predictor of specificity LA Rabia, Y Zhang, SD Ludwig, MC Julian, PM Tessier Protein Engineering, Design and Selection 31 (11), 409-418, 2018 | 64 | 2018 |
Physicochemical rules for identifying monoclonal antibodies with drug-like specificity Y Zhang, L Wu, P Gupta, AA Desai, MD Smith, LA Rabia, SD Ludwig, ... Molecular pharmaceutics 17 (7), 2555-2569, 2020 | 43 | 2020 |
Dual-ligand zeolitic imidazolate framework crystals and oriented films derived from metastable mono-ligand ZIF-108 Y Ban, Y Peng, Y Zhang, H Jin, W Jiao, A Guo, P Wang, Y Li, W Yang Microporous and Mesoporous Materials 219, 190-198, 2016 | 23 | 2016 |
Rational affinity maturation of anti-amyloid antibodies with high conformational and sequence specificity AA Desai, MD Smith, Y Zhang, EK Makowski, JE Gerson, E Ionescu, ... Journal of Biological Chemistry 296, 2021 | 22 | 2021 |
Antibodies with Weakly Basic Isoelectric Points Minimize Trade-offs between Formulation and Physiological Colloidal Properties P Gupta, EK Makowski, S Kumar, Y Zhang, JM Scheer, PM Tessier Mol. Pharmaceutics 19 (3), 775–787, 2022 | 19 | 2022 |
Directed evolution of conformation‐specific antibodies for sensitive detection of polypeptide aggregates in therapeutic drug formulations W Lou, SD Stimple, AA Desai, EK Makowski, S Kalyoncu, JE Mogensen, ... Biotechnology and Bioengineering 118 (2), 797-808, 2021 | 3 | 2021 |
Janus particle rotator-to-lamellar nucleation and growth kinetics DJ Beltran-Villegas, Y Zhang, RG Larson The Journal of Chemical Physics 146 (9), 2017 | 2 | 2017 |