| Fumaric acid production by fermentation CA Roa Engel, AJJ Straathof, TW Zijlmans, WM van Gulik, ... Applied microbiology and biotechnology 78, 379-389, 2008 | 468 | 2008 |
| Quantitative analysis of the microbial metabolome by isotope dilution mass spectrometry using uniformly 13C-labeled cell extracts as internal standards L Wu, MR Mashego, JC van Dam, AM Proell, JL Vinke, C Ras, ... Analytical biochemistry 336 (2), 164-171, 2005 | 468 | 2005 |
| Quantitative evaluation of intracellular metabolite extraction techniques for yeast metabolomics AB Canelas, A ten Pierick, C Ras, RM Seifar, JC van Dam, WM van Gulik, ... Analytical chemistry 81 (17), 7379-7389, 2009 | 406 | 2009 |
| Role of transcriptional regulation in controlling fluxes in central carbon metabolism of Saccharomyces cerevisiae: a chemostat culture study P Daran-Lapujade, MLA Jansen, JM Daran, W van Gulik, JH de Winde, ... Journal of Biological Chemistry 279 (10), 9125-9138, 2004 | 323 | 2004 |
| MIRACLE: mass isotopomer ratio analysis of U13Clabeled extracts. A new method for accurate quantification of changes in concentrations of intracellular … MR Mashego, L Wu, JC Van Dam, C Ras, JL Vinke, WA Van Winden, ... Biotechnology and bioengineering 85 (6), 620-628, 2004 | 319 | 2004 |
| Leakage-free rapid quenching technique for yeast metabolomics AB Canelas, C Ras, A Ten Pierick, JC van Dam, JJ Heijnen, ... Metabolomics 4, 226-239, 2008 | 280 | 2008 |
| The fluxes through glycolytic enzymes in Saccharomyces cerevisiae are predominantly regulated at posttranscriptional levels P Daran-Lapujade, S Rossell, WM van Gulik, MAH Luttik, MJL de Groot, ... Proceedings of the National Academy of Sciences 104 (40), 15753-15758, 2007 | 270 | 2007 |
| A metabolic network stoichiometry analysis of microbial growth and product formation WM Van Gulik, JJ Heijnen Biotechnology and bioengineering 48 (6), 681-698, 1995 | 262 | 1995 |
| Towards large scale fermentative production of succinic acid MLA Jansen, WM van Gulik Current opinion in biotechnology 30, 190-197, 2014 | 239 | 2014 |
| Metabolic-flux analysis of Saccharomyces cerevisiae CEN.PK113-7D based on mass isotopomer measurements of 13C-labeled primary metabolites WA Van Winden, JC Van Dam, C Ras, RJ Kleijn, JL Vinke, WM Van Gulik, ... FEMS yeast research 5 (6-7), 559-568, 2005 | 201 | 2005 |
| Development and application of a differential method for reliable metabolome analysis in Escherichia coli H Taymaz-Nikerel, M De Mey, C Ras, A ten Pierick, RM Seifar, ... Analytical biochemistry 386 (1), 9-19, 2009 | 193 | 2009 |
| Measuring enzyme activities under standardized in vivolike conditions for systems biology K Van Eunen, J Bouwman, P DaranLapujade, J Postmus, AB Canelas, ... The FEBS journal 277 (3), 749-760, 2010 | 190 | 2010 |
| Termination of trial of streptokinase in severe acute ischaemic stroke M Hommel, JP Boissel, C Cornu, F Boutitie, KR Lees, G Besson, D Leys, ... The Lancet 345 (8941), 57, 1995 | 184 | 1995 |
| Application of metabolic flux analysis for the identification of metabolic bottlenecks in the biosynthesis of penicillinG WM Van Gulik, W De Laat, JL Vinke, JJ Heijnen Biotechnology and Bioengineering 68 (6), 602-618, 2000 | 160 | 2000 |
| Determination of the cytosolic free NAD/NADH ratio in Saccharomyces cerevisiae under steadystate and highly dynamic conditions AB Canelas, WM van Gulik, JJ Heijnen Biotechnology and bioengineering 100 (4), 734-743, 2008 | 151 | 2008 |
| Critical evaluation of sampling techniques for residual glucose determination in carbonlimited chemostat culture of Saccharomyces cerevisiae MR Mashego, WM Van Gulik, JL Vinke, JJ Heijnen Biotechnology and bioengineering 83 (4), 395-399, 2003 | 142 | 2003 |
| Fast sampling for quantitative microbial metabolomics WM Van Gulik Current opinion in biotechnology 21 (1), 27-34, 2010 | 135 | 2010 |
| Rapid sampling for analysis of in vivo kinetics using the BioScope: a system for continuouspulse experiments D Visser, GA van Zuylen, JC van Dam, A Oudshoorn, MR Eman, C Ras, ... Biotechnology and bioengineering 79 (6), 674-681, 2002 | 125 | 2002 |
| Plant biotechnology for the production of alkaloids: present status and prospects R Verpoorte, R van der Heijden, WM van Gulik, HJG ten Hoopen The alkaloids: chemistry and pharmacology 40, 1-187, 1991 | 125 | 1991 |
| An in vivo data-driven framework for classification and quantification of enzyme kinetics and determination of apparent thermodynamic data AB Canelas, C Ras, A ten Pierick, WM van Gulik, JJ Heijnen Metabolic engineering 13 (3), 294-306, 2011 | 120 | 2011 |
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