Nathanael Gray

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Ken WestoverAssociate Professor of Biochemistry and Radiation Oncology, UT SouthwesternVerified email at utsouthwestern.edu
Richard YoungProfessor of Biology, MITVerified email at wi.mit.edu
Laurent MeijerVerified email at manros-therapeutics.com
Peter K. SorgerHarvard Medical SchoolVerified email at hms.harvard.edu
Stefan KnappUniversity of FrankfurtVerified email at pharmchem.uni-frankfurt.de
Young-Tae ChangPOSTECHVerified email at postech.ac.kr
Zachary Hunter, PhDDana-Farber Cancer Institute - Bing Center for WMVerified email at dfci.harvard.edu
Ultan McDermottFaculty, Wellcome Trust Sanger InstituteVerified email at sanger.ac.uk
Mario NiepelRibon TherapeuticsVerified email at ribontx.com
John R. EngenJames L. Waters Chair & Distinguished Professor of Chemistry, Northeastern UniversityVerified email at neu.edu
Elizabeth A. WinzelerProfessor, University of California San Diego, School of MedicineVerified email at ucsd.edu
Lyn JonesDana-Farber Cancer InstituteVerified email at dfci.harvard.edu
Badry BursulayaGNFVerified email at gnf.org
Craig MermelPresident and Chief Product Officer, Precision NeuroscienceVerified email at precisionneuro.io
Daniel LimMIT Koch InstituteVerified email at mit.edu
Simon ArthurUniversity of DundeeVerified email at dundee.ac.uk
Roxana IacobResearch Associate Professor, Northeastern UniversityVerified email at neu.edu
Neal RosenProfessor of Pharmacology, Memorial Sloan-Kettering Cancer CenterVerified email at mskcc.org
Thorold W. TheunissenAssistant Professor of Developmental Biology at Washington University in St. LouisVerified email at wustl.edu
Gad GetzMassachusetts General Hospital and Broad Institute of Harvard and MITVerified email at broadinstitute.org

Nathanael Gray

Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School

Verified email at dfci.harvard.edu

medicinal chemistry cancer research structure-based drug design kinase inhibitors chemical biology


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Targeting cancer with small molecule kinase inhibitors J Zhang, PL Yang, NS Gray Nature reviews cancer 9 (1), 28-39, 2009	3076	2009
Systematic identification of genomic markers of drug sensitivity in cancer cells MJ Garnett, EJ Edelman, SJ Heidorn, CD Greenman, A Dastur, KW Lau, ... Nature 483 (7391), 570-575, 2012	2375	2012
A next generation connectivity map: L1000 platform and the first 1,000,000 profiles A Subramanian, R Narayan, SM Corsello, DD Peck, TE Natoli, X Lu, ... Cell 171 (6), 1437-1452. e17, 2017	1985	2017
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1 CC Thoreen, SA Kang, JW Chang, Q Liu, J Zhang, Y Gao, LJ Reichling, ... Journal of Biological Chemistry 284 (12), 8023-8032, 2009	1917	2009
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival TR Peterson, M Laplante, CC Thoreen, Y Sancak, SA Kang, WM Kuehl, ... Cell 137 (5), 873-886, 2009	1449	2009
A landscape of pharmacogenomic interactions in cancer F Iorio, TA Knijnenburg, DJ Vis, GR Bignell, MP Menden, M Schubert, ... Cell 166 (3), 740-754, 2016	1414	2016
A unifying model for mTORC1-mediated regulation of mRNA translation CC Thoreen, L Chantranupong, HR Keys, T Wang, NS Gray, DM Sabatini Nature 485 (7396), 109-113, 2012	1410	2012
Rational design of inhibitors that bind to inactive kinase conformations Y Liu, NS Gray Nature chemical biology 2 (7), 358-364, 2006	1245	2006
A chemical switch for inhibitor-sensitive alleles of any protein kinase AC Bishop, JA Ubersax, DT Petsch, DP Matheos, NS Gray, J Blethrow, ... nature 407 (6802), 395-401, 2000	1200	2000
EML4-ALK Fusion Gene and Efficacy of an ALK Kinase Inhibitor in Lung Cancer JP Koivunen, C Mermel, K Zejnullahu, C Murphy, E Lifshits, AJ Holmes, ... Clinical cancer research 14 (13), 4275-4283, 2008	1148	2008
Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors NS Gray, L Wodicka, AMWH Thunnissen, TC Norman, S Kwon, ... Science 281 (5376), 533-538, 1998	1131	1998
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling PP Hsu, SA Kang, J Rameseder, Y Zhang, KA Ottina, D Lim, TR Peterson, ... science 332 (6035), 1317-1322, 2011	1122	2011
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M W Zhou, D Ercan, L Chen, CH Yun, D Li, M Capelletti, AB Cortot, ... Nature 462 (7276), 1070-1074, 2009	1101	2009
Activating mutations in ALK provide a therapeutic target in neuroblastoma RE George, T Sanda, M Hanna, S Fröhling, WL Ii, J Zhang, Y Ahn, ... Nature 455 (7215), 975-978, 2008	946	2008
Systematic identification of culture conditions for induction and maintenance of naive human pluripotency TW Theunissen, BE Powell, H Wang, M Mitalipova, DA Faddah, J Reddy, ... Cell stem cell 15 (4), 471-487, 2014	812	2014
The promise and peril of chemical probes CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ... Nature chemical biology 11 (8), 536-541, 2015	748	2015
MEK1 mutations confer resistance to MEK and B-RAF inhibition CM Emery, KG Vijayendran, MC Zipser, AM Sawyer, L Niu, JJ Kim, ... Proceedings of the National Academy of Sciences 106 (48), 20411-20416, 2009	729	2009
Targeting transcription regulation in cancer with a covalent CDK7 inhibitor N Kwiatkowski, T Zhang, PB Rahl, BJ Abraham, J Reddy, SB Ficarro, ... Nature 511 (7511), 616-620, 2014	709	2014
YY1 is a structural regulator of enhancer-promoter loops AS Weintraub, CH Li, AV Zamudio, AA Sigova, NM Hannett, DS Day, ... Cell 171 (7), 1573-1588. e28, 2017	701	2017
Kinase inhibitors: the road ahead FM Ferguson, NS Gray Nature reviews Drug discovery 17 (5), 353-377, 2018	700	2018

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