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James Maksymetz
James Maksymetz
Verified email at gene.com
Title
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Year
Targeting metabotropic glutamate receptors for novel treatments of schizophrenia
J Maksymetz, SP Moran, PJ Conn
Molecular brain 10, 1-19, 2017
1392017
Induction and expression of fear sensitization caused by acute traumatic stress
JN Perusini, EM Meyer, VA Long, V Rau, N Nocera, J Avershal, ...
Neuropsychopharmacology 41 (1), 45-57, 2016
1152016
Targeting muscarinic acetylcholine receptors for the treatment of psychiatric and neurological disorders
SP Moran, J Maksymetz, PJ Conn
Trends in pharmacological sciences 40 (12), 1006-1020, 2019
1012019
M 1-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition
SP Moran, JW Dickerson, HP Cho, Z Xiang, J Maksymetz, DH Remke, ...
Neuropsychopharmacology 43 (8), 1763-1771, 2018
692018
mGlu2 and mGlu3 negative allosteric modulators divergently enhance thalamocortical transmission and exert rapid antidepressant-like effects
ME Joffe, CI Santiago, KH Oliver, J Maksymetz, NA Harris, JL Engers, ...
Neuron 105 (1), 46-59. e3, 2020
662020
A Novel M1 PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity
JM Rook, JL Bertron, HP Cho, PM Garcia-Barrantes, SP Moran, ...
ACS chemical neuroscience 9 (9), 2274-2285, 2018
542018
Mechanisms underlying prelimbic prefrontal cortex mGlu3/mGlu5-dependent plasticity and reversal learning deficits following acute stress
ME Joffe, CI Santiago, BJ Stansley, J Maksymetz, RG Gogliotti, JL Engers, ...
Neuropharmacology 144, 19-28, 2019
532019
Cross-species transcriptomic atlas of dorsal root ganglia reveals species-specific programs for sensory function
M Jung, M Dourado, J Maksymetz, A Jacobson, BI Laufer, M Baca, ...
Nature Communications 14 (1), 366, 2023
452023
Acute restraint stress redirects prefrontal cortex circuit function through mGlu5 receptor plasticity on somatostatin-expressing interneurons
ME Joffe, J Maksymetz, JR Luschinger, S Dogra, AS Ferranti, DJ Luessen, ...
Neuron 110 (6), 1068-1083. e5, 2022
392022
M1 Muscarinic Receptors Modulate Fear-Related Inputs to the Prefrontal Cortex: Implications for Novel Treatments of Posttraumatic Stress Disorder
J Maksymetz, ME Joffe, SP Moran, BJ Stansley, B Li, K Temple, ...
Biological psychiatry 85 (12), 989-1000, 2019
322019
PF-06827443 displays robust allosteric agonist and positive allosteric modulator activity in high receptor reserve and native systems
SP Moran, HP Cho, J Maksymetz, DH Remke, RM Hanson, ...
ACS chemical neuroscience 9 (9), 2218-2224, 2018
252018
mGlu1 potentiation enhances prelimbic somatostatin interneuron activity to rescue schizophrenia-like physiological and cognitive deficits
J Maksymetz, NE Byun, DJ Luessen, B Li, RL Barry, JC Gore, ...
Cell Reports 37 (5), 109950, 2021
212021
mGlu5 Positive Allosteric Modulators Facilitate Long-Term Potentiation via Disinhibition Mediated by mGlu5-Endocannabinoid Signaling
Z Xiang, X Lv, J Maksymetz, BJ Stansley, A Ghoshal, RG Gogliotti, ...
ACS pharmacology & translational science 2 (3), 198-209, 2019
202019
Biased M1 receptor–positive allosteric modulators reveal role of phospholipase D in M1-dependent rodent cortical plasticity
SP Moran, Z Xiang, CA Doyle, J Maksymetz, X Lv, S Faltin, NM Fisher, ...
Science signaling 12 (610), eaax2057, 2019
122019
Nav1. 7 is essential for nociceptor action potentials in the mouse in a manner independent of endogenous opioids
L Deng, M Dourado, RM Reese, K Huang, SD Shields, KL Stark, ...
Neuron 111 (17), 2642-2659. e13, 2023
102023
Human motor neurons are rare and can be transcriptomically divided into known subtypes
O Gautier, JA Blum, J Maksymetz, D Chen, C Schweingruber, I Mei, ...
bioRxiv, 2023.04. 05.535689, 2023
52023
Challenges of profiling motor neuron transcriptomes from human spinal cord
O Gautier, JA Blum, J Maksymetz, D Chen, C Schweingruber, I Mei, ...
Neuron 111 (23), 3739-3741, 2023
22023
High-resolution cross-species transcriptomic atlas of dorsal root ganglia reveals species-specific programs for sensory function
M Jung, M Dourado, J Maksymetz, A Jacobson, M Baca, O Foreman, ...
bioRxiv, 2022.06. 21.497049, 2022
12022
mGlu Receptor Modulation in Murine Models of Stress and Affective Disorders
J Maksymetz, ME Joffe
Metabotropic Glutamate Receptor Technologies, 259-296, 2021
12021
Biased M1 positive allosteric modulators reveal novel role of phospholipase D in M1-dependent rodent cortical plasticity
SP Moran, Z Xiang, CA Doyle, J Maksymetz, X Lv, S Faltin, CM Niswender, ...
bioRxiv, 806943, 2019
12019
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