| Chromone as a privileged scaffold in drug discovery: recent advances: miniperspective J Reis, A Gaspar, N Milhazes, F Borges Journal of medicinal chemistry 60 (19), 7941-7957, 2017 | 310 | 2017 |
| Alzheimer's disease, enzyme targets and drug discovery struggles: from natural products to drug prototypes T Silva, J Reis, J Teixeira, F Borges Ageing research reviews 15, 116-145, 2014 | 200 | 2014 |
| Discovery of new chemical entities for old targets: insights on the lead optimization of chromone-based monoamine oxidase B (MAO-B) inhibitors J Reis, F Cagide, D Chavarria, T Silva, C Fernandes, A Gaspar, E Uriarte, ... Journal of Medicinal Chemistry 59 (12), 5879-5893, 2016 | 97 | 2016 |
| Chromone 3-phenylcarboxamides as potent and selective MAO-B inhibitors A Gaspar, J Reis, A Fonseca, N Milhazes, D Viña, E Uriarte, F Borges Bioorganic & medicinal chemistry letters 21 (2), 707-709, 2011 | 95 | 2011 |
| A closer look into NADPH oxidase inhibitors: Validation and insight into their mechanism of action J Reis, M Massari, S Marchese, M Ceccon, FS Aalbers, F Corana, ... Redox biology 32, 101466, 2020 | 82 | 2020 |
| Combining QSAR classification models for predictive modeling of human monoamine oxidase inhibitors AM Helguera, A Pérez-Garrido, A Gaspar, J Reis, F Cagide, D Vina, ... European journal of medicinal chemistry 59, 75-90, 2013 | 73 | 2013 |
| Tight-binding inhibition of human monoamine oxidase B by chromone analogs: a kinetic, crystallographic, and biological analysis J Reis, N Manzella, F Cagide, J Mialet-Perez, E Uriarte, A Parini, F Borges, ... Journal of Medicinal Chemistry 61 (9), 4203-4212, 2018 | 65 | 2018 |
| Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors J Reis, F Cagide, ME Valencia, J Teixeira, D Bagetta, C Perez, E Uriarte, ... European Journal of Medicinal Chemistry 158, 781-800, 2018 | 61 | 2018 |
| Coumarin versus chromone monoamine oxidase B inhibitors: quo vadis? A Fonseca, J Reis, T Silva, MJ Matos, D Bagetta, F Ortuso, S Alcaro, ... Journal of Medicinal Chemistry 60 (16), 7206-7212, 2017 | 54 | 2017 |
| Discovery of two new classes of potent monoamine oxidase-B inhibitors by tricky chemistry F Cagide, T Silva, J Reis, A Gaspar, F Borges, LR Gomes, JN Low Chemical communications 51 (14), 2832-2835, 2015 | 54 | 2015 |
| Discovery of novel A3 adenosine receptor ligands based on chromone scaffold A Gaspar, J Reis, S Kachler, S Paoletta, E Uriarte, KN Klotz, S Moro, ... Biochemical Pharmacology 84 (1), 21-29, 2012 | 53 | 2012 |
| In search for new chemical entities as adenosine receptor ligands: Development of agents based on benzo-γ-pyrone skeleton A Gaspar, J Reis, MJ Matos, E Uriarte, F Borges European journal of medicinal chemistry 54, 914-918, 2012 | 34 | 2012 |
| Accelerating lead optimization of chromone carboxamide scaffold throughout microwave-assisted organic synthesis F Cagide, J Reis, A Gaspar, F Borges Tetrahedron letters 52 (48), 6446-6449, 2011 | 32 | 2011 |
| An elegant four-helical fold in NOX and STEAP enzymes facilitates electron transport across biomembranes—Similar vehicle, different destination W Oosterheert, J Reis, P Gros, A Mattevi Accounts of Chemical Research 53 (9), 1969-1980, 2020 | 21 | 2020 |
| Parkinson's disease management. Part II-discovery of MAO-B inhibitors based on nitrogen heterocycles and analogues J Reis, I Encarnacao, A Gaspar, A Morales, N Milhazes, F Borges Current Topics in Medicinal Chemistry 12 (20), 2116-2130, 2012 | 20 | 2012 |
| Exploring coumarin potentialities: development of new enzymatic inhibitors based on the 6-methyl-3-carboxamidocoumarin scaffold A Fonseca, MJ Matos, J Reis, Y Duarte, M Gutiérrez, L Santana, E Uriarte, ... RSC advances 6 (55), 49764-49768, 2016 | 16 | 2016 |
| Navigating in chromone chemical space: discovery of novel and distinct A 3 adenosine receptor ligands F Cagide, A Gaspar, J Reis, D Chavarria, S Vilar, G Hripcsak, E Uriarte, ... RSC advances 5 (96), 78572-78585, 2015 | 13 | 2015 |
| Structural characterization of some N-phenyl-4-oxo-4H-2-chromone carboxamides LR Gomes, JN Low, F Cagide, A Gaspar, J Reis, F Borges Acta Crystallographica Section B: Structural Science, Crystal Engineering …, 2013 | 12 | 2013 |
| Synthesis, spectroscopic characterization and X-ray structure of novel 7-methoxy-4-oxo-N-phenyl-4H-chromene-2-carboxamides J Reis, A Gaspar, F Borges, LR Gomes, JN Low Journal of Molecular Structure 1056, 31-37, 2014 | 8 | 2014 |
| Synthesis and NMR studies of novel chromone‐2‐carboxamide derivatives A Gaspar, F Cagide, E Quezada, J Reis, E Uriarte, F Borges Magnetic resonance in Chemistry 51 (4), 251-254, 2013 | 8 | 2013 |
