Michael Costanzo
Michael Costanzo
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The genetic landscape of a cell
M Costanzo, A Baryshnikova, J Bellay, Y Kim, ED Spear, CS Sevier, ...
science 327 (5964), 425-431, 2010
A global genetic interaction network maps a wiring diagram of cellular function
M Costanzo, B VanderSluis, EN Koch, A Baryshnikova, C Pons, G Tan, ...
Science 353 (6306), aaf1420, 2016
CDK activity antagonizes Whi5, an inhibitor of G1/S transcription in yeast
M Costanzo, JL Nishikawa, X Tang, JS Millman, O Schub, K Breitkreuz, ...
Cell 117 (7), 899-913, 2004
Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress
JM Tkach, A Yimit, AY Lee, M Riffle, M Costanzo, D Jaschob, JA Hendry, ...
Nature cell biology 14 (9), 966-976, 2012
Widespread expansion of protein interaction capabilities by alternative splicing
X Yang, J Coulombe-Huntington, S Kang, GM Sheynkman, T Hao, ...
Cell 164 (4), 805-817, 2016
Evaluation and design of genome-wide CRISPR/SpCas9 knockout screens
T Hart, AHY Tong, K Chan, J Van Leeuwen, A Seetharaman, M Aregger, ...
G3: Genes, Genomes, Genetics 7 (8), 2719-2727, 2017
Systematic exploration of essential yeast gene function with temperature-sensitive mutants
Z Li, FJ Vizeacoumar, S Bahr, J Li, J Warringer, FS Vizeacoumar, R Min, ...
Nature biotechnology 29 (4), 361-367, 2011
Quantitative analysis of fitness and genetic interactions in yeast on a genome scale
A Baryshnikova, M Costanzo, Y Kim, H Ding, J Koh, K Toufighi, JY Youn, ...
Nature methods 7 (12), 1017-1024, 2010
The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast
TF Menne, B Goyenechea, N Sánchez-Puig, CC Wong, LM Tonkin, ...
Nature genetics 39 (4), 486-495, 2007
Systematic exploration of synergistic drug pairs
M Cokol, HN Chua, M Tasan, B Mutlu, ZB Weinstein, Y Suzuki, ME Nergiz, ...
Molecular systems biology 7 (1), 544, 2011
Systematic mapping of genetic interaction networks
SJ Dixon, M Costanzo, A Baryshnikova, B Andrews, C Boone
Annual review of genetics 43 (1), 601-625, 2009
Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome
AJ Finch, C Hilcenko, N Basse, LF Drynan, B Goyenechea, TF Menne, ...
Genes & development 25 (9), 917-929, 2011
Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA
S Leidel, PGA Pedrioli, T Bucher, R Brost, M Costanzo, A Schmidt, ...
Nature 458 (7235), 228-232, 2009
Systematic analysis of complex genetic interactions
E Kuzmin, B VanderSluis, W Wang, G Tan, R Deshpande, Y Chen, M Usaj, ...
Science 360 (6386), eaao1729, 2018
Global gene deletion analysis exploring yeast filamentous growth
O Ryan, RS Shapiro, CF Kurat, D Mayhew, A Baryshnikova, B Chin, ...
Science 337 (6100), 1353-1356, 2012
Synthetic genetic array (SGA) analysis in Saccharomyces cerevisiae and Schizosaccharomyces pombe
A Baryshnikova, M Costanzo, S Dixon, FJ Vizeacoumar, CL Myers, ...
Methods in enzymology 470, 145-179, 2010
An integrated approach to characterize genetic interaction networks in yeast metabolism
B Szappanos, K Kovács, B Szamecz, F Honti, M Costanzo, ...
Nature genetics 43 (7), 656-662, 2011
The interaction network of the chaperonin CCT
C Dekker, PC Stirling, EA McCormack, H Filmore, A Paul, RL Brost, ...
The EMBO journal 27 (13), 1827-1839, 2008
Molecular chaperone Hsp90 stabilizes Pih1/Nop17 to maintain R2TP complex activity that regulates snoRNA accumulation
R Zhao, Y Kakihara, A Gribun, J Huen, G Yang, M Khanna, M Costanzo, ...
The Journal of cell biology 180 (3), 563-578, 2008
Global genetic networks and the genotype-to-phenotype relationship
M Costanzo, E Kuzmin, J van Leeuwen, B Mair, J Moffat, C Boone, ...
Cell 177 (1), 85-100, 2019
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