| In vivo evidence for serine biosynthesis-defined sensitivity of lung metastasis, but not of primary breast tumors, to mTORC1 inhibition G Rinaldi, E Pranzini, J Van Elsen, D Broekaert, CM Funk, M Planque, ... Molecular cell 81 (2), 386-397. e7, 2021 | 76 | 2021 |
| Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer J Li, S Ohmura, A Marchetto, MF Orth, R Imle, M Dallmayer, J Musa, ... Nature Communications 12 (1), 5356, 2021 | 13 | 2021 |
| Proliferation assessment by trypan blue exclusion in ewing sarcoma CM Funk, J Musa Ewing Sarcoma: Methods and Protocols, 151-158, 2021 | 9 | 2021 |
| EIF4EBP1 is transcriptionally upregulated by MYCN and associates with poor prognosis in neuroblastoma K Voeltzke, K Scharov, CM Funk, A Kahler, D Picard, L Hauffe, MF Orth, ... Cell Death Discovery 8 (1), 157, 2022 | 6 | 2022 |
| Integrative gene network and functional analyses identify a prognostically relevant key regulator of metastasis in Ewing sarcoma F Cidre-Aranaz, J Li, TLB Hölting, MF Orth, R Imle, S Kutschmann, ... Molecular Cancer 21, 1-7, 2022 | 3 | 2022 |
| Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma TLB Hölting, F Cidre-Aranaz, D Matzek, B Popper, SJ Jacobi, CM Funk, ... Molecular Cancer 21 (1), 199, 2022 | 2 | 2022 |
| 4EBP1/2 support tumorigenicity and cell survival during energetic stress by translationally regulating fatty acid synthesis T Levy, K Voeltzke, L Hauffe, K Alasad, M Snaebjörnsson, R Marciano, ... bioRxiv, 2022.09. 09.507243, 2022 | 1 | 2022 |
| mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism T Levy, K Voeltzke, L Hruby, K Alasad, Z Bas, M Snaebjörnsson, ... Nature Communications 15 (1), 4083, 2024 | | 2024 |
| Glutaredoxin 3 (GLRX3) confers a fusion oncogene-dependent vulnerability to Ewing sarcoma E Vinca, AC Ehlers, A Ritter, D Obermeier, CM Funk, FH Geyer, ... bioRxiv, 2024.04. 24.590877, 2024 | | 2024 |
| Chromosome 8 gain drives cancer progression by hijacking the translation factor 4E-BP1 sensitizing for targeted CDK4/6 inhibition CM Funk, AC Ehlers, MF Orth, K Aljakouch, J Li, TLB Hölting, R Will, ... bioRxiv, 2022.12. 11.519935, 2022 | | 2022 |
| Convergent genetic mechanisms drive EIF4EBP1 overexpression, translational deregulation and tumorigenesis in Ewing sarcoma C Funk, MF Orth, K Aljakouch, J Li, R Imle, L Romero-Perez, TLB Hoelting, ... ONCOLOGY RESEARCH AND TREATMENT 45 (SUPPL 3), 234-235, 2022 | | 2022 |
| Systems biology analysis identifies TCF7L1 as a key regulator of metastasis in Ewing sarcoma F Cidre-Aranaz, J Li, TLB Hölting, MF Orth, R Imle, S Kutschmann, ... bioRxiv, 2021.02. 25.432862, 2021 | | 2021 |
