| Inhibition of dihydroorotate dehydrogenase overcomes differentiation blockade in acute myeloid leukemia DB Sykes, YS Kfoury, FE Mercier, MJ Wawer, JM Law, MK Haynes, ... Cell 167 (1), 171-186. e15, 2016 | 436 | 2016 |
| Unexplored therapeutic opportunities in the human genome TI Oprea, CG Bologa, S Brunak, A Campbell, GN Gan, A Gaulton, ... Nature reviews Drug discovery 17 (5), 317-332, 2018 | 362 | 2018 |
| Drug repurposing from an academic perspective TI Oprea, JE Bauman, CG Bologa, T Buranda, A Chigaev, BS Edwards, ... Drug Discovery Today: Therapeutic Strategies 8 (3-4), 61-69, 2011 | 353 | 2011 |
| Pharos: collating protein information to shed light on the druggable genome DT Nguyen, S Mathias, C Bologa, S Brunak, N Fernandez, A Gaulton, ... Nucleic acids research 45 (D1), D995-D1002, 2017 | 254 | 2017 |
| Characterization of a Cdc42 protein inhibitor and its use as a molecular probe L Hong, SR Kenney, GK Phillips, D Simpson, CE Schroeder, J Nöth, ... Journal of Biological Chemistry 288 (12), 8531-8543, 2013 | 183 | 2013 |
| Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential S Chauhan, Z Ahmed, SB Bradfute, J Arko-Mensah, MA Mandell, ... Nature communications 6 (1), 8620, 2015 | 152 | 2015 |
| A potent and selective inhibitor of Cdc42 GTPase Z Surviladze, A Waller, JJ Strouse, C Bologa, O Ursu, V Salas, ... Probe Reports from the NIH Molecular Libraries Program [Internet], 2010 | 145 | 2010 |
| Probe reports from the nih molecular libraries program Z Surviladze, A Waller, JJ Strouse, C Bologa, O Ursu, V Salas, ... Bethesda (MD), 2010 | 136 | 2010 |
| TCRD and Pharos 2021: mining the human proteome for disease biology TK Sheils, SL Mathias, KJ Kelleher, VB Siramshetty, DT Nguyen, ... Nucleic Acids Research 49 (D1), D1334-D1346, 2021 | 117 | 2021 |
| A Competitive Nucleotide Binding Inhibitor: In Vitro Characterization of Rab7 GTPase Inhibition JO Agola, L Hong, Z Surviladze, O Ursu, A Waller, JJ Strouse, ... ACS chemical biology 7 (6), 1095-1108, 2012 | 107 | 2012 |
| Regulation of cell adhesion by affinity and conformational unbending of α4β1 integrin A Chigaev, A Waller, GJ Zwartz, T Buranda, LA Sklar The Journal of Immunology 178 (11), 6828-6839, 2007 | 97 | 2007 |
| Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay Z Surviladze, A Waller, Y Wu, E Romero, BS Edwards, A Wandinger-Ness, ... Journal of biomolecular screening 15 (1), 10-20, 2010 | 88 | 2010 |
| Fluorescent substrates for flow cytometric evaluation of efflux inhibition in ABCB1, ABCC1, and ABCG2 transporters JJ Strouse, I Ivnitski-Steele, A Waller, SM Young, D Perez, AM Evangelisti, ... Analytical biochemistry 437 (1), 77-87, 2013 | 67 | 2013 |
| Galphas-coupled receptor signaling actively down-regulates α4β1-integrin affinity: A possible mechanism for cell de-adhesion A Chigaev, A Waller, O Amit, LA Sklar BMC immunology 9, 1-16, 2008 | 59 | 2008 |
| Real-time analysis of conformation-sensitive antibody binding provides new insights into integrin conformational regulation A Chigaev, A Waller, O Amit, L Halip, CG Bologa, LA Sklar Journal of Biological Chemistry 284 (21), 14337-14346, 2009 | 58 | 2009 |
| Novel activities of select NSAID R-enantiomers against Rac1 and Cdc42 GTPases TI Oprea, LA Sklar, JO Agola, Y Guo, M Silberberg, J Roxby, A Vestling, ... PLoS One 10 (11), e0142182, 2015 | 47 | 2015 |
| Glutathione‐S‐transferase‐green fluorescent protein fusion protein reveals slow dissociation from high site density beads and measures free GSH M Tessema, PC Simons, DF Cimino, L Sanchez, A Waller, RG Posner, ... Cytometry Part A 69 (5), 326-334, 2006 | 43 | 2006 |
| Techniques: GPCR assembly, pharmacology and screening by flow cytometry A Waller, PC Simons, SM Biggs, BS Edwards, ER Prossnitz, LA Sklar Trends in pharmacological sciences 25 (12), 663-669, 2004 | 43 | 2004 |
| Detection of intracellular granularity induction in prostate cancer cell lines by small molecules using the HyperCyt® high-throughput flow cytometry system MK Haynes, JJ Strouse, A Waller, A Leitao, RF Curpan, C Bologa, ... SLAS Discovery 14 (6), 596-609, 2009 | 41 | 2009 |
| A Pan-GTPase inhibitor as a molecular probe L Hong, Y Guo, S BasuRay, JO Agola, E Romero, DS Simpson, ... PLoS One 10 (8), e0134317, 2015 | 40 | 2015 |
