Zamal Ahmed
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Inhibition of basal FGF receptor signaling by dimeric Grb2
CC Lin, FA Melo, R Ghosh, KM Suen, LJ Stagg, J Kirkpatrick, ST Arold, ...
Cell 149 (7), 1514-1524, 2012
The APS adapter protein couples the insulin receptor to the phosphorylation of c-Cbl and facilitates ligand-stimulated ubiquitination of the insulin receptor
Z Ahmed, BJ Smith, TS Pillay
FEBS letters 475 (1), 31-34, 2000
APS, an adapter protein with a PH and SH2 domain, is a substrate for the insulin receptor kinase
Z Ahmed, BJ Smith, K Kotani, P Wilden, TS Pillay
Biochemical Journal 341 (3), 665-668, 1999
Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity
Z Ahmed, CC Lin, KM Suen, FA Melo, JA Levitt, K Suhling, JE Ladbury
Journal of Cell Biology 200 (4), 493-504, 2013
Adapter protein with a pleckstrin homology (PH) and an Src homology 2 (SH2) domain (APS) and SH2-B enhance insulin-receptor autophosphorylation, extracellular-signal-regulated …
Z Ahmed, TS Pillay
Biochemical Journal 371 (2), 405-412, 2003
Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death
JH Houl, Z Ye, CA Brosey, LPF Balapiti-Modarage, S Namjoshi, A Bacolla, ...
Nature communications 10 (1), 5654, 2019
Grb2 monomer–dimer equilibrium determines normal versus oncogenic function
Z Ahmed, Z Timsah, KM Suen, NP Cook, GR Lee IV, CC Lin, M Gagea, ...
Nature communications 6 (1), 7354, 2015
Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling
Z Ahmed, AC Schüller, K Suhling, C Tregidgo, JE Ladbury
Biochemical Journal 413 (1), 37-49, 2008
Competition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion
Z Timsah, Z Ahmed, CC Lin, FA Melo, LJ Stagg, PG Leonard, P Jeyabal, ...
Nature structural & molecular biology 21 (2), 180-188, 2014
Direct binding of Grb2 SH3 domain to FGFR2 regulates SHP2 function
Z Ahmed, R George, CC Lin, KM Suen, JA Levitt, K Suhling, JE Ladbury
Cellular signalling 22 (1), 23-33, 2010
Functional effects of APS and SH2-B on insulin receptor signalling
Z Ahmed, TS Pillay
Biochemical Society Transactions 29 (4), 529-534, 2001
A novel dual kinase function of the RET proto-oncogene negatively regulates activating transcription factor 4-mediated apoptosis
R Bagheri-Yarmand, KM Sinha, AE Gururaj, Z Ahmed, YQ Rizvi, ...
Journal of Biological Chemistry 290 (18), 11749-11761, 2015
Cancer mutational burden is shaped by G4 DNA, replication stress and mitochondrial dysfunction
A Bacolla, Z Ye, Z Ahmed, JA Tainer
Progress in biophysics and molecular biology 147, 47-61, 2019
Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer
Z Timsah, Z Ahmed, C Ivan, J Berrout, M Gagea, Y Zhou, GNA Pena, X Hu, ...
Oncogene 35 (17), 2186-2196, 2016
Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly (ADP-ribose) glycohydrolase (PARG) structures with inhibitors
CA Brosey, JH Houl, P Katsonis, LPF Balapiti-Modarage, S Bommagani, ...
Progress in Biophysics and Molecular Biology 163, 171-186, 2021
Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli
KM Suen, CC Lin, R George, FA Melo, ER Biggs, Z Ahmed, MN Drake, ...
Nature structural & molecular biology 20 (5), 620-627, 2013
Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state
CC Lin, KM Suen, PA Jeffrey, L Wieteska, JA Lidster, P Bao, AP Curd, ...
Molecular cell 82 (6), 1089-1106. e12, 2022
Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2)
AC Schüller, Z Ahmed, JA Levitt, KM Suen, K Suhling, JE Ladbury
Biochemical Journal 416 (2), 189-199, 2008
Distinct spatial and temporal distribution of ZAP70 and Lck following stimulation of interferon and T-cell receptors
Z Ahmed, CA Beeton, MA Williams, D Clements, CT Baldari, JE Ladbury
Journal of molecular biology 353 (5), 1001-1010, 2005
Vitamin E enhances cancer immunotherapy by reinvigorating dendritic cells via targeting checkpoint SHP1
X Yuan, Y Duan, Y Xiao, K Sun, Y Qi, Y Zhang, Z Ahmed, D Moiani, J Yao, ...
Cancer discovery 12 (7), 1742-1759, 2022
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