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Rainer Heuchel
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Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling
A Nakao, M Afrakhte, A Morn, T Nakayama, JL Christian, R Heuchel, ...
Nature 389 (6651), 631-635, 1997
23981997
The transcription factor MTF‐1 is essential for basal and heavy metal‐induced metallothionein gene expression.
R Heuchel, F Radtke, O Georgiev, G Stark, M Aguet, W Schaffner
The EMBO journal 13 (12), 2870-2875, 1994
6031994
Cloned transcription factor MTF‐1 activates the mouse metallothionein I promoter.
F Radtke, R Heuchel, O Georgiev, M Hergersberg, M Gariglio, Z Dembic, ...
The EMBO journal 12 (4), 1355-1362, 1993
4631993
Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy
E Lonardo, PC Hermann, MT Mueller, S Huber, A Balic, ...
Cell stem cell 9 (5), 433-446, 2011
4462011
3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing
P Longati, X Jia, J Eimer, A Wagman, MR Witt, S Rehnmark, C Verbeke, ...
BMC cancer 13, 1-13, 2013
3982013
Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1
Ç Günes, R Heuchel, O Georgiev, KH Müller, P Lichtlen, H Blüthmann, ...
The EMBO journal 17 (10), 2846-2854, 1998
3351998
Thionein (apometallothionein) can modulate DNA binding and transcription activation by zinc finger containing factor Spl
J Zeng, R Heuchel, W Schaffner, JHR Kägi
FEBS letters 279 (2), 310-312, 1991
3321991
Transforming growth factor-β1 (TGF-β)–induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-β-activated kinase 1 and mitogen-activated …
S Edlund, S Bu, N Schuster, P Aspenstrom, R Heuchel, NE Heldin, ...
Molecular biology of the cell 14 (2), 529-544, 2003
3252003
The protective role of Smad7 in diabetic kidney disease: mechanism and therapeutic potential
HY Chen, XR Huang, W Wang, JH Li, RL Heuchel, ACK Chung, HY Lan
Diabetes 60 (2), 590-601, 2011
2672011
Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate
M Furuhashi, T Sjöblom, A Abramsson, J Ellingsen, P Micke, H Li, ...
Cancer research 64 (8), 2725-2733, 2004
2532004
Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1
E Brugnera, O Georgiev, F Radtke, R Heuchel, E Baker, GR Sutherland, ...
Nucleic acids research 22 (15), 3167-3173, 1994
2491994
Platelet-derived growth factor β receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3′ kinase signaling
R Heuchel, A Berg, M Tallquist, K Åhlén, RK Reed, K Rubin, ...
Proceedings of the National Academy of Sciences 96 (20), 11410-11415, 1999
2321999
The nucleotides responsible for the direct physical contact between the chromatin insulator protein CTCF and the H19 imprinting control region manifest parent of origin …
V Pant, P Mariano, C Kanduri, A Mattsson, V Lobanenkov, R Heuchel, ...
Genes & development 17 (5), 586-590, 2003
2112003
Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice
ACK Chung, XR Huang, L Zhou, R Heuchel, KN Lai, HY Lan
Nephrology Dialysis Transplantation 24 (5), 1443-1454, 2009
2072009
Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer
E Hessmann, MS Patzak, L Klein, N Chen, V Kari, I Ramu, TE Bapiro, ...
Gut 67 (3), 497-507, 2018
2002018
Efficient TGF-β induction of the Smad7 gene requires cooperation between AP-1, Sp1, and Smad proteins on the mouse Smad7 promoter
G Brodin, A Åhgren, P ten Dijke, CH Heldin, R Heuchel
Journal of Biological Chemistry 275 (37), 29023-29030, 2000
1972000
Transient activation of NF-κB through a TAK1/IKK kinase pathway by TGF-β1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation
M Arsura, GR Panta, JD Bilyeu, LG Cavin, MA Sovak, AA Oliver, V Factor, ...
Oncogene 22 (3), 412-425, 2003
1932003
Desmoplasia and chemoresistance in pancreatic cancer
M Schober, R Jesenofsky, R Faissner, C Weidenauer, W Hagmann, ...
Cancers 6 (4), 2137-2154, 2014
1652014
Profibrogenic transforming growth factor‐β/activin receptor–like kinase 5 signaling via connective tissue growth factor expression in hepatocytes
HL Weng, L Ciuclan, Y Liu, J Hamzavi, P Godoy, H Gaitantzi, S Kanzler, ...
Hepatology 46 (4), 1257-1270, 2007
1532007
Real-time assessment of tissue hypoxia in vivo with combined photoacoustics and high-frequency ultrasound
M Gerling, Y Zhao, S Nania, KJ Norberg, CS Verbeke, B Englert, ...
Theranostics 4 (6), 604, 2014
1322014
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