| TGLI1 transcription factor mediates breast cancer brain metastasis via activating metastasis-initiating cancer stem cells and astrocytes in the tumor microenvironment SR Sirkisoon, RL Carpenter, T Rimkus, D Doheny, D Zhu, NR Aguayo, ... Oncogene 39 (1), 64-78, 2020 | 82 | 2020 |
| Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis D Doheny, S Sirkisoon, RL Carpenter, NR Aguayo, AT Regua, ... Oncogene 39 (42), 6589-6605, 2020 | 58 | 2020 |
| Breast cancer extracellular vesicles-derived miR-1290 activates astrocytes in the brain metastatic microenvironment via the FOXA2→ CNTF axis to promote progression of brain … SR Sirkisoon, GL Wong, NR Aguayo, DL Doheny, D Zhu, AT Regua, ... Cancer letters 540, 215726, 2022 | 27 | 2022 |
| Transgenic mouse models of breast cancer AT Regua, A Arrigo, D Doheny, GL Wong, HW Lo Cancer letters 516, 73-83, 2021 | 11 | 2021 |
| Trk receptor tyrosine kinases in metastasis and cancer therapy AT Regua, DL Doheny, AB Arrigo, HW Lo Discovery Medicine 28 (154), 195-203, 2019 | 11 | 2019 |
| NEDD4 degrades TUSC2 to promote glioblastoma progression TK Rimkus, AB Arrigo, D Zhu, RL Carpenter, S Sirkisoon, D Doheny, ... Cancer letters 531, 124-135, 2022 | 6 | 2022 |
| TrkA interacts with and phosphorylates STAT3 to enhance gene transcription and promote breast cancer stem cells in triple-negative and HER2-enriched breast cancers AT Regua, NR Aguayo, SA Jalboush, DL Doheny, SG Manore, D Zhu, ... Cancers 13 (10), 2340, 2021 | 6 | 2021 |
| Tumor suppressor candidate 2 (TUSC2): discovery, functions, and cancer therapy A Arrigo, AT Regua, MK Najjar, HW Lo Cancers 15 (9), 2455, 2023 | 2 | 2023 |
| Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis (vol 39, pg 6589, 2020) D Doheny, S Sirkisoon, RL Carpenter, NR Aguayo, AT Regua, ... ONCOGENE, 2024 | | 2024 |
| Correction: Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis D Doheny, S Sirkisoon, RL Carpenter, NR Aguayo, AT Regua, ... Oncogene, 2024 | | 2024 |
| Functional characterization of TUSC2 for its role as a novel tumor suppressor for malignant glioma ABJ Arrigo Wake Forest University, 2024 | | 2024 |
| Dual targeting of JAK2 and TrkA inhibits breast cancer cell stemness, enhances apoptosis, and delays tumor growth of triple-negative and HER2-enriched breast cancers AT Regua, MK Najjar, GL Wong, SG Manore, A Arrigo, HW Lo Cancer Research 83 (7_Supplement), 1721-1721, 2023 | | 2023 |
| Investigating TUSC2 for its tumor suppressive functions in glioblastoma and its role in gliomagenesis A Arrigo, M Najjar, A Regua, HW Lo Cancer Research 83 (7_Supplement), 2603-2603, 2023 | | 2023 |
| Astrocytes activated by tGLI1-expressing breast cancer brain metastases upregulate CNTF to activate astrocytes and promote breast cancer stem cells GL Wong, SR Sirkisoon, NR Aguayo, DL Doheny, D Zhu, AT Regua, ... Cancer Research 82 (12_Supplement), 2354-2354, 2022 | | 2022 |
| tGLI1 and IL-6/IL-6R/GP130/STAT3 pathways cooperate to promote breast cancer stem cells and are co-activated in HER2-enriched and triple-negative breast cancers SG Manore, DL Doheny, D Zhu, GL Wong, AT Regua, A Arrigo, ... Cancer Research 82 (12_Supplement), 92-92, 2022 | | 2022 |
| TrkA and JAK2-STAT3 pathway crosstalk promotes breast cancer stem cells in HER2-enriched and triple-negative breast cancers AT Regua, D Zhu, DL Doheny, GL Wong, SG Manore, CJ Wagner, ... Cancer Research 82 (12_Supplement), 1039-1039, 2022 | | 2022 |
| JAK2/STAT3 and TrkA pathways are frequently co-activated in triple-negative and HER2-enriched breast cancers and the co-activation correlates with an increased potential of … AT Regua, NR Aguayo, SA Jalboush, DL Doheny, SG Manore, D Zhu, ... Cancer Research 81 (13_Supplement), 1979-1979, 2021 | | 2021 |
| Novel transgenic mouse model of tGLI1 for in vivo studies of breast cancer and glioblastoma AT Regua, D Zhu, A Arrigo, D Doheny, HW Lo Cancer Research 80 (16_Supplement), 425-425, 2020 | | 2020 |
| Tumor-specific gain-of-function tGLI1 transcription factor is a novel mediator of breast cancer stem cells and a novel transcriptional activator of cancer stemness genes SR Sirkisoon, RL Carpenter, T Rimkus, D Doheny, D Zhu, NR Aguayo, ... Cancer Research 79 (13_Supplement), 3689-3689, 2019 | | 2019 |
