Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5 AK Upadhyay, M Cyr, K Longenecker, R Tripathi, C Sun, DJ Kempf Acta Crystallographica Section F: Structural Biology Communications 73 (3 …, 2017 | 99 | 2017 |
A widely-applicable high-throughput cellular thermal shift assay (CETSA) using split Nano Luciferase NJ Martinez, RR Asawa, MG Cyr, A Zakharov, DJ Urban, JS Roth, ... Scientific reports 8 (1), 9472, 2018 | 88 | 2018 |
Structure-based engineering of irreversible inhibitors against histone lysine demethylase KDM5A JR Horton, CB Woodcock, Q Chen, X Liu, X Zhang, J Shanks, G Rai, ... Journal of medicinal chemistry 61 (23), 10588-10601, 2018 | 32 | 2018 |
Siglec-6 is a target for chimeric antigen receptor T-cell treatment of chronic lymphocytic leukemia D Kovalovsky, JH Yoon, MG Cyr, S Simon, E Voynova, C Rader, ... Leukemia 35 (9), 2581-2591, 2021 | 17 | 2021 |
Siglec-6 on chronic lymphocytic leukemia cells is a target for post-allogeneic hematopoietic stem cell transplantation antibodies J Chang, H Peng, BC Shaffer, S Baskar, IC Wecken, MG Cyr, GJ Martinez, ... Cancer immunology research 6 (9), 1008-1013, 2018 | 14 | 2018 |
Patient-derived Siglec-6-targeting antibodies engineered for T-cell recruitment have potential therapeutic utility in chronic lymphocytic leukemia MG Cyr, M Mhibik, J Qi, H Peng, J Chang, EM Gaglione, D Eik, J Herrick, ... Journal for Immunotherapy of Cancer 10 (11), 2022 | 5 | 2022 |
Siglec-6 as a therapeutic target for cell migration and adhesion in chronic lymphocytic leukemia J Nunes, R Tafesse, C Mao, M Purcell, X Mo, L Zhang, M Long, MG Cyr, ... Nature Communications 15 (1), 5180, 2024 | | 2024 |
Concerted Antibody and Antigen Discovery by Differential Whole-cell Phage Display Selections and Multi-omic Target Deconvolution MG Cyr, HD Wilson, AL Spierling, J Chang, H Peng, P Steinberger, ... Journal of Molecular Biology 435 (10), 168085, 2023 | | 2023 |
Exploring the therapeutic potential of a novel Siglec-6 targeted bispecific antibody to selectively kill leukemia cells J Nunes, C Mao, M Purcell, E Perry, L Zhang, X Mo, M Cyr, M Long, J Byrd, ... Cancer Research 83 (7_Supplement), 2966-2966, 2023 | | 2023 |
Antibody-Driven Target Discovery and Antibody Engineering for Cancer Treatment MG Cyr The Scripps Research Institute, 2022 | | 2022 |
Systematic target deconvolution: Are we there yet? G Zahoranszky-Kohalmi, R Guha, M Cyr, C Danchik, S Fang, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 258, 2019 | | 2019 |
Riding the waves of PPI-network perturbations to predict phenotypic assay outcome G Zahoranszky-Kohalmi, R Guha, M Cyr, M Henderson, S Fang, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 256, 2018 | | 2018 |