Nonproteolytic K29-linked ubiquitination of the PB2 replication protein of influenza A viruses by proviral cullin 4-based E3 ligases M Karim, E Biquand, M Declercq, Y Jacob, S van Der Werf, C Demeret Mbio 11 (2), 10.1128/mbio. 00305-20, 2020 | 24 | 2020 |
In silico analysis revealed Zika virus miRNAs associated with viral pathogenesis through alteration of host genes involved in immune response and neurological functions MS Islam, MAAK Khan, MW Murad, M Karim, ABMMK Islam Journal of medical virology 91 (9), 1584-1594, 2019 | 24 | 2019 |
Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for antiviral strategies M Karim, S Saul, L Ghita, MK Sahoo, C Ye, N Bhalla, CW Lo, J Jin, ... Antiviral Research 204, 105367, 2022 | 18 | 2022 |
Comparative profiling of ubiquitin proteasome system interplay with influenza A virus PB2 polymerase protein recapitulating virus evolution in humans E Biquand, J Poirson, M Karim, M Declercq, N Malausse, P Cassonnet, ... MSphere 2 (6), 10.1128/msphere. 00330-17, 2017 | 15 | 2017 |
Discovery of pan-ErbB inhibitors protecting from SARS-CoV-2 replication, inflammation, and lung injury by a drug repurposing screen S Saul, M Karim, PT Huang, L Ghita, W Chiu, S Kumar, N Bhalla, ... bioRxiv, 2021 | 14 | 2021 |
BIKE regulates dengue virus infection and is a cellular target for broad-spectrum antivirals S Pu, S Schor, M Karim, S Saul, M Robinson, S Kumar, LI Prugar, ... Antiviral Research 184, 104966, 2020 | 12 | 2020 |
Preparing for the next viral threat with broad-spectrum antivirals M Karim, CW Lo, S Einav Journal of Clinical Investigation 133 (11), e170236, 2023 | 8 | 2023 |
In Silico identification of potential drug targets by subtractive genome analysis of Enterococcus faecium DO M Karim, MDN Islam, GMN Azad Jewel BioRxiv, 2020.02. 14.948232, 2020 | 6 | 2020 |
Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects S Saul, M Karim, L Ghita, PT Huang, W Chiu, V Durán, CW Lo, S Kumar, ... The Journal of Clinical Investigation, 2023 | 5 | 2023 |
The transcriptional landscape of Venezuelan equine encephalitis virus (TC-83) infection Z Yao, F Zanini, S Kumar, M Karim, S Saul, N Bhalla, N Panpradist, ... PLoS neglected tropical diseases 15 (3), e0009306, 2021 | 5 | 2021 |
Influenza A virus co-opts ERI1 exonuclease bound to histone mRNA to promote viral transcription M Declercq, E Biquand, M Karim, N Pietrosemoli, Y Jacob, C Demeret, ... Nucleic acids research 48 (18), 10428-10440, 2020 | 5 | 2020 |
The cargo adaptor protein CLINT1 is phosphorylated by the Numb-associated kinase BIKE and mediates dengue virus infection S Schor, S Pu, V Nicolaescu, S Azari, M Kõivomägi, M Karim, ... Journal of Biological Chemistry, 2022 | 4 | 2022 |
Chemical inactivation strategies for SARS-CoV-2-infected cells and organoids M Karim, AA Pohane, CW Lo, S Einav, J Garhyan STAR Protocols 5 (1), 102906, 2024 | 1 | 2024 |
Design of SARS-CoV-2 protease inhibitors with improved affinity and reduced sensitivity to mutations M Westberg, Y Su, X Zou, P Huang, A Rustagi, J Garhyan, PB Patel, ... bioRxiv, 2023.07. 19.549739, 2023 | 1 | 2023 |
Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for therapy M Karim, S Saul, L Ghita, MK Sahoo, C Ye, N Bhalla, J Jin, JG Park, ... bioRxiv, 2022.03. 18.484178, 2022 | 1 | 2022 |
An orally bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced sensitivity to mutations M Westberg, Y Su, X Zou, P Huang, A Rustagi, J Garhyan, PB Patel, ... Science Translational Medicine 16 (738), eadi0979, 2024 | | 2024 |
PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2 M Karim, M Mishra, CW Lo, S Saul, HB Cagirici, DH Nhu Tran, A Agrawal, ... bioRxiv, 2024.04. 15.589676, 2024 | | 2024 |
Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent dual EPHA2/GAK kinase inhibitors with antiviral activity J Gerninghaus, R Zhubi, A Kraemer, M Karim, DHN Tran, AC Joerger, ... bioRxiv, 2024.02. 18.580805, 2024 | | 2024 |
Design of SARS-CoV-2 protease inhibitors with improved affinity and reduced sensitivity to mutations (preprint) M Westberg, Y Su, X Zou, P Huang, A Rustagi, J Garhyan, PB Patel, ... | | 2023 |