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Winston Stauffer
Winston Stauffer
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ATF6 regulates cardiac hypertrophy by transcriptional induction of the mTORC1 activator, Rheb
EA Blackwood, C Hofmann, M Santo Domingo, AS Bilal, A Sarakki, ...
Circulation research 124 (1), 79-93, 2019
932019
Mesencephalic astrocyte–derived neurotrophic factor is an ER-resident chaperone that protects against reductive stress in the heart
A Arrieta, EA Blackwood, WT Stauffer, M Santo Domingo, AS Bilal, ...
Journal of Biological Chemistry 295 (22), 7566-7583, 2020
342020
ATF6 as a Nodal Regulator of Proteostasis in the Heart
CC Glembotski, A Arrieta, EA Blackwood, WT Stauffer
Frontiers in physiology 11, 527299, 2020
292020
The ER unfolded protein response effector, ATF6, reduces cardiac fibrosis and decreases activation of cardiac fibroblasts
WT Stauffer, EA Blackwood, K Azizi, RJ Kaufman, CC Glembotski
International journal of molecular sciences 21 (4), 1373, 2020
242020
Integrating ER and mitochondrial proteostasis in the healthy and diseased heart
A Arrieta, EA Blackwood, WT Stauffer, CC Glembotski
Frontiers in Cardiovascular Medicine 6, 193, 2020
232020
Designing novel therapies to mend broken hearts: ATF6 and cardiac proteostasis
EA Blackwood, AS Bilal, WT Stauffer, A Arrieta, CC Glembotski
Cells 9 (3), 602, 2020
122020
Sledgehammer to scalpel: broad challenges to the heart and other tissues yield specific cellular responses via transcriptional regulation of the ER-stress master regulator ATF6α
WT Stauffer, A Arrieta, EA Blackwood, CC Glembotski
International Journal of Molecular Sciences 21 (3), 1134, 2020
102020
MANF, A Structurally Unique Redox-Sensitive Chaperone, Restores ER Protein Folding in the Ischemic Heart.
A Arrieta, EA Blackwood, WT Stauffer, M Santo Domingo, AN Pentoney, ...
Circulation Research 121 (suppl_1), A2-A2, 2017
22017
MANF, a structurally unique ER stress-inducible protein, restores ER-protein folding in ER stressed cardiac Myocytes and in the ischemic heart
A Arrieta, EA Blackwood, WT Stauffer, AN Pentoney, DJ Thuerauf, ...
Circulation 134 (suppl_1), A19772-A19772, 2016
22016
Mice lacking cyclophilin B, but not cyclophilin A, are protected from the development of NASH in a diet and chemical-induced model
WT Stauffer, AZ Goodman, M Bobardt, DR Ure, RT Foster, P Gallay
Plos one 19 (3), e0298211, 2024
12024
The Cyclophilin Inhibitor Rencofilstat Decreases HCV-Induced Hepatocellular Carcinoma Independently of Its Antiviral Activity
W Stauffer, M Bobardt, D Ure, R Foster, P Gallay
Viruses 15 (10), 2099, 2023
12023
ATF6 and the adaptive ER stress response promotes proliferation and viability of mouse cardiac progenitor cells
WT Stauffer, S Doroudgar, HN Stephens, B Bailey, CC Glembotski
Circulation 132 (suppl_3), A18348-A18348, 2015
12015
Cyclophilin D knockout significantly prevents HCC development in a streptozotocin-induced mouse model of diabetes-linked NASH
WT Stauffer, M Bobardt, DR Ure, RT Foster, P Gallay
Plos one 19 (4), e0301711, 2024
2024
Mice lacking Cyclophilin B, but not Cyclophilin A, are significantly protected from the development of major features of NAFLD/NASH in a diet and chemical-induced model
W Stauffer, D Ure, R Foster, P Gallay
Journal of Hepatology 78, S748, 2023
2023
Cyclophilin inhibition with rencofilstat shifts the liver transcriptome and lipidome in preclinical models toward resolution of non-alcoholic steatohepatitis
D Ure, W Stauffer, B Variya, L Haddon, P Mayo, P Gallay, R Foster
Journal of Hepatology 78, S770, 2023
2023
The Cyclophilin Inhibitor Rencofilstat Decreases HCV-induced Hepatocellular Carcinoma Independently of Its Antiviral Activity
PA Gallay, W Stauffer, M Bobardt, D Ure, R Foster
bioRxiv, 2023.08. 19.553982, 2023
2023
CYCLOPHILIN B KNOCKOUT SIGNIFICANTLY LIMITS THE DEVELOPMENT OF LIVER FIBROSIS IN A DIET AND CHEMICAL-INDUCED MOUSE MODEL OF NAFLD/NASH
WT Stauffer, D Ure, R Foster, P Gallay
HEPATOLOGY 76, S792-S792, 2022
2022
Rencofilstat, a pan-cyclophilin inhibitor, exerts diverse metabolic and transcriptional anti-tumor activities in a murine NASH-HCC model
D Ure, J Kuo, W Stauffer, L Haddon, P Mayo, R Foster, P Gallay
Journal of Hepatology 77, S660, 2022
2022
Cyclophilin D knockout promotes cell death pathways in preventing HCC development in a streptozotocin-induced mouse model of diabetes-linked NASH
W Stauffer, J Kuo, D Ure, R Foster, P Gallay
Journal of Hepatology 77, S650, 2022
2022
EFFECT of ASTODRIMER SODIUM AGAINST SARS-CoV-2 VARIANTS (Α, Β, Γ, Δ, Κ) in VITRO
P Gallay, C Luscombe, W Stauffer, MD Bobardt, G Heery, A Castellarnau, ...
Topics in Antiviral Medicine, 182-183, 2022
2022
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