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Alexandre Côté
Alexandre Côté
Principal Scientist II, Schrodinger
Verified email at schrodinger.com - Homepage
Title
Cited by
Cited by
Year
Asymmetric, catalytic synthesis of α-chiral amines using a novel bis (phosphine) monoxide chiral ligand
AA Boezio, J Pytkowicz, A Côté, AB Charette
Journal of the American chemical society 125 (47), 14260-14261, 2003
2332003
Identification of a benzoisoxazoloazepine inhibitor (CPI-0610) of the bromodomain and extra-terminal (BET) family as a candidate for human clinical trials
BK Albrecht, VS Gehling, MC Hewitt, RG Vaswani, A Côté, Y Leblanc, ...
Journal of medicinal chemistry 59 (4), 1330-1339, 2016
2102016
Disrupting acetyl-lysine recognition: progress in the development of bromodomain inhibitors
FA Romero, AM Taylor, TD Crawford, V Tsui, A Côté, S Magnuson
Journal of medicinal chemistry 59 (4), 1271-1298, 2016
1872016
Catalytic asymmetric addition of diorganozinc reagents to N-phosphinoylalkylimines
A Côté, AA Boezio, AB Charette
Proceedings of the National Academy of Sciences 101 (15), 5405-5410, 2004
1282004
Discovery, design, and optimization of isoxazole azepine BET inhibitors
VS Gehling, MC Hewitt, RG Vaswani, Y Leblanc, A Côté, CG Nasveschuk, ...
ACS medicinal chemistry letters 4 (9), 835-840, 2013
1242013
Diving into the water: inducible binding conformations for BRD4, TAF1 (2), BRD9, and CECR2 bromodomains
TD Crawford, V Tsui, EM Flynn, S Wang, AM Taylor, A Côté, JE Audia, ...
Journal of Medicinal Chemistry 59 (11), 5391-5402, 2016
1112016
Fragment-based discovery of a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor (CPI-637)
AM Taylor, A Côté, MC Hewitt, R Pastor, Y Leblanc, CG Nasveschuk, ...
ACS Medicinal Chemistry Letters 7 (5), 531-536, 2016
1002016
General method for the expedient synthesis of salt-free diorganozinc reagents using zinc methoxide
A Côté, AB Charette
Journal of the American Chemical Society 130 (9), 2771-2773, 2008
1002008
Discovery of a potent and selective in vivo probe (GNE-272) for the bromodomains of CBP/EP300
TD Crawford, FA Romero, KW Lai, V Tsui, AM Taylor, G de Leon Boenig, ...
Journal of medicinal chemistry 59 (23), 10549-10563, 2016
912016
Application of the chiral bis (phosphine) monoxide ligand to catalytic enantioselective addition of dialkylzinc reagents to β-Nitroalkenes
A Côté, VNG Lindsay, AB Charette
Organic Letters 9 (1), 85-87, 2007
782007
Evidence for the Structure of the Enantioactive Ligand in the Phosphine–Copper‐Catalyzed Addition of Diorganozinc Reagents to Imines
A Côté, AA Boezio, AB Charette
Angewandte Chemie International Edition 43 (47), 6525-6528, 2004
742004
Regulatory T cell modulation by CBP/EP300 bromodomain inhibition
S Ghosh, A Taylor, M Chin, HR Huang, AR Conery, JA Mertz, A Salmeron, ...
Journal of Biological Chemistry 291 (25), 13014-13027, 2016
692016
Enantioselective synthesis of β-amino alcohols and α-amino acids via a copper catalyzed addition of diorganozinc reagents to N-phosphinoylimines
JN Desrosiers, A Côté, AB Charette
Tetrahedron 61 (26), 6186-6192, 2005
592005
Multicomponent one-pot procedure for the synthesis of free α-chiral amines from aldehydes
A Côté, AB Charette
The Journal of Organic Chemistry 70 (26), 10864-10867, 2005
582005
Method and apparatus for preparing pure water
WW Carson, KJ Sims, B Mack, RJ Ritz, WC Whitehill
US Patent 6,796,436, 2004
582004
Bromodomain inhibitors and uses thereof
BK Albrecht, JE Audia, A Côté, VS Gehling, JC Harmange, MC Hewitt, ...
US Patent 9,249,161, 2016
572016
Bromodomain inhibitors and uses thereof
BK Albrecht, JE Audia, A Côté, VS Gehling, JC Harmange, MC Hewitt, ...
US Patent 8,796,261, 2014
552014
Asymmetric catalytic addition of diorganozinc reagents to imines: Scope and application
AB Charette, AA Boezio, A Côté, E Moreau, J Pytkowicz, JN Desrosiers, ...
Pure and applied chemistry 77 (7), 1259-1267, 2005
492005
Automatic pan/tilt pointing device, luminaire follow-spot, and 6DOF 3D position/orientation calculation information
W Bauer, R Lozano-Hemmer
US Patent App. 10/155,764, 2002
432002
Preparation of enantiomerically enriched (1S)-1-phenylpropan-1-amine hydrochloride by a catalytic addition of diorganozinc reagents to imines:[Benzenemethanamine,-ethyl …
JN Desrosiers, A Côté, AA Boezio, AB Charette, SE Denmark, ...
Organic Syntheses 83, 5-17, 2006
402006
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