Plasma cell–derived mtDAMPs activate the macrophage STING pathway, promoting myeloma progression A Jibril, C Hellmich, EE Wojtowicz, K Hampton, R Maynard, R De Silva, ... Blood, The Journal of the American Society of Hematology 141 (25), 3065-3077, 2023 | 6 | 2023 |
Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes BB Johnson, MV Cosson, LI Tsansizi, TL Holmes, T Gilmore, K Hampton, ... Cell Reports 43 (1), 2024 | 3 | 2024 |
Acute myeloid leukemia-driven IL-3-dependent upregulation of BCL2 in non-malignant hematopoietic stem and progenitor cells increases venetoclax-induced cytopenias DJ Fowler-Shorten, RS Maynard, K Hampton, A Altera, M Markham, ... Haematologica 109 (5), 1576, 2024 | 1 | 2024 |
Sting agonists activate bone marrow macrophages and synergise with anti-CD47 blockade improving survival in animal models of acute myeloid leukemia RS Maynard, C Hellmich, K Hampton, A Jibril, KM Bowles, SA Rushworth Blood 140 (Supplement 1), 9096-9096, 2022 | 1 | 2022 |
Regulation of intestinal senescence during cholestatic liver disease modulates barrier function and liver disease progression M Moreno-Gonzalez, K Hampton, P Ruiz, G Beasy, FSP Nagies, A Parker, ... JHEP Reports 6 (10), 101159, 2024 | | 2024 |
Low protein diet protects the liver from Salmonella Typhimurium-mediated injury by modulating the mTOR/autophagy axis in macrophages EE Wojtowicz, K Hampton, M Moreno-Gonzalez, CL Utting, Y Lan, P Ruiz, ... Communications Biology 7 (1), 1219, 2024 | | 2024 |
Low protein diet protects liver function upon Salmonella infection by metabolic reprogramming of macrophages EE Wojtowicz, K Hampton, M Moreno-Gonzalez, CL Utting, Y Lan, P Ruiz, ... bioRxiv, 2024.03. 01.582753, 2024 | | 2024 |
The Aging Bone Marrow Niche Disrupts Glutamine Metabolism By Upregulating HSC Derived Glutamine Synthetase C Hellmich, EE Wojtowicz, D Fowler-Shorten, RS Maynard, K Hampton, ... Blood 142, 1304, 2023 | | 2023 |
Multiple Myeloma Induced IL-6 Reprograms Lipid Metabolism through a CD36 Dependent Mechanism M Ehikioya, A Altera, K Hampton, RS Maynard, D Fowler-Shorten, ... Blood 142, 6566, 2023 | | 2023 |
Sting Activation in Bone Marrow Macrophages Targets AML Blasts for Phagocytosis in an ICAM-1 Dependent Mechanism R De Silva, M Markham, RS Maynard, K Hampton, C Hellmich, ... Blood 142, 1597, 2023 | | 2023 |
AML Inhibits Lipid Uptake By the Liver through an HGF/c-MET Dependent Mechanism Which Results in an Increased Supply of Free Fatty Acid to the Tumor RS Maynard, C Hellmich, K Hampton, D Fowler-Shorten, M Markham, ... Blood 142, 6031, 2023 | | 2023 |
Acute Myeloid Leukemia Driven IL-3 Dependent Upregulation of BCL-2 in Non-Malignant Hematopoietic Progenitor Cells Increases Venetoclax Induced Cytopenias D Fowler-Shorten, RS Maynard, K Hampton, M Ehikioya, EE Wojtowicz, ... Blood 142, 293, 2023 | | 2023 |
IL-6 Mediates a Switch in Free Fatty Acid Metabolism from the Liver to the Bone Marrow to Support HSC Expansion during Infection K Hampton, J Mistry, RS Maynard, D Fowler-Shorten, C Hellmich, ... Blood 142, 1332, 2023 | | 2023 |
Sphingomyelinase Regulates the Release of Protumoral Mitochondria Containing-Vesicles from AML Cells M Markham, D Riley, RS Maynard, K Hampton, R De Silva, C Hellmich, ... Blood 142 (Supplement 1), 4337-4337, 2023 | | 2023 |
P469: ACUTE MYELOID LEUKEMIA DRIVES BCL-2 UPREGULATION IN NON MALIGNANT HSPCS WHICH IS TARGETED BY VENETOCLAX AND CAUSES CYTOPENIA D Fowler-Shorten, R Maynard, K Hampton, M Ehikioya, R De Silva, ... HemaSphere 7 (S3), e3268551, 2023 | | 2023 |
P856: MULTIPLE MYELOMA DERIVED IL-6 REDUCES FATTY ACID METABOLISM IN THE LIVER BY DOWNREGULATING CD36 AND CPT1A IN HEPATOCYTES ME Ehikioya, R Maynard, K Hampton, C Hellmich, R De Silva, ... HemaSphere 7 (S3), e4035637, 2023 | | 2023 |
P1341: LC3-ASSOCIATED PHAGOCYTOSIS IS IMPAIRED IN BONE MARROW MACROPHAGES DURING AGEING LEADING TO DEFECTIVE PHAGOCYTOSIS AND ACCUMULATION OF APOPTOTIC DEBRIS WITHIN THE BONE … K Hampton, C Hellmich, R Maynard, A Jibril, J Moore, K Bowles, ... HemaSphere 7 (S3), e10197d2, 2023 | | 2023 |
P431: ACTIVATION OF MACROPHAGE STING ENHANCES PHAGOCYTOSIS OF ACUTE MYELOID LEUKAEMIA R Maynard, C Hellmich, K Hampton, J Moore, A Jibril, R De Silva, ... HemaSphere 7 (S3), e31638b3, 2023 | | 2023 |
P423: ACUTE MYELOID LEUKEMIA REPROGRAMS LIPID METABOLISM BY DOWNREGULATING CD36 EXPRESSION IN HEPATOCYTES. R Maynard, K Hampton, C Hellmich, M Ehikioya, D Fowler-Shorten, ... HemaSphere 7 (S3), e41966d7, 2023 | | 2023 |
Mitochondrial Membrane Potential Defines the HSC Population with Serial Repopulating Potential in Young but Not Aged Animals C Hellmich, E Wojtowicz, RS Maynard, K Hampton, JJ Mistry, JA Moore, ... Blood 140 (Supplement 1), 8580-8581, 2022 | | 2022 |