Ribosomally-synthesised cyclic peptides from plants as drug leads and pharmaceutical scaffolds DJ Craik, MH Lee, FBH Rehm, B Tombling, B Doffek, H Peacock Bioorganic & medicinal chemistry 26 (10), 2727-2737, 2018 | 44 | 2018 |
EGF‐like and other disulfide‐rich microdomains as therapeutic scaffolds BJ Tombling, CK Wang, DJ Craik Angewandte Chemie International Edition 59 (28), 11218-11232, 2020 | 38 | 2020 |
The emerging landscape of peptide-based inhibitors of PCSK9 BJ Tombling, Y Zhang, YH Huang, DJ Craik, CK Wang Atherosclerosis 330, 52-60, 2021 | 26 | 2021 |
Bioactive cyclization optimizes the affinity of a proprotein convertase subtilisin/kexin type 9 (PCSK9) peptide inhibitor BJ Tombling, C Lammi, N Lawrence, EK Gilding, G Grazioso, DJ Craik, ... Journal of Medicinal Chemistry 64 (5), 2523-2533, 2020 | 15 | 2020 |
In Planta Discovery and Chemical Synthesis of Bracelet Cystine Knot Peptides from Rinorea bengalensis TT Dang, LY Chan, BJ Tombling, PJ Harvey, EK Gilding, DJ Craik Journal of Natural Products 84 (2), 395-407, 2021 | 11 | 2021 |
Engineered EGF-A peptides with improved affinity for proprotein convertase subtilisin/kexin type 9 (PCSK9) BJ Tombling, C Lammi, N Lawrence, J Li, A Arnoldi, DJ Craik, CK Wang ACS Chemical Biology 16 (2), 429-439, 2021 | 7 | 2021 |
Increased valency improves inhibitory activity of peptides targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) BJ Tombling, C Lammi, C Bollati, A Anoldi, DJ Craik, CK Wang ChemBioChem 22 (12), 2154-2160, 2021 | 5 | 2021 |
The acyclotide ribe 31 from Rinorea bengalensis has selective cytotoxicity and potent insecticidal properties in Drosophila TT Dang, YH Huang, S Ott, PJ Harvey, EK Gilding, BJ Tombling, LY Chan, ... Journal of Biological Chemistry 298 (10), 2022 | 3 | 2022 |
Improving Stability Enhances In Vivo Efficacy of a PCSK9 Inhibitory Peptide Y Zhang, L Wang, BJ Tombling, C Lammi, YH Huang, Y Li, M Bartolomei, ... Journal of the American Chemical Society 144 (42), 19485-19498, 2022 | 1 | 2022 |
EGF‐artige und andere disulfidreiche Mikrodomänen als therapeutische Molekülgerüste BJ Tombling, CK Wang, DJ Craik Angewandte Chemie 132 (28), 11314-11328, 2020 | 1 | 2020 |
Cystine-knot peptide inhibitors of HTRA1 bind to a cryptic pocket within the active site region Y Li, Y Wei, M Ultsch, W Li, W Tang, B Tombling, X Gao, Y Dimitrova, ... Nature Communications 15 (1), 4359, 2024 | | 2024 |
The development of peptide-based cholesterol-lowering therapeutics B Tombling | | 2021 |
m-Terphenyl-stabilized boron (bis) triflates D Vidovic, DCH Do, BJ Tombling, SP Koo ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 250, 2015 | | 2015 |