| A DNA hypomethylation signature predicts antitumor activity of LSD1 inhibitors in SCLC HP Mohammad, KN Smitheman, CD Kamat, D Soong, KE Federowicz, ... Cancer cell 28 (1), 57-69, 2015 | 489 | 2015 |
| Long-range inhibitor-induced conformational regulation of human IRE1α endoribonuclease activity NO Concha, A Smallwood, W Bonnette, R Totoritis, G Zhang, ... Molecular pharmacology 88 (6), 1011-1023, 2015 | 57 | 2015 |
| Structure-based design of a novel SMYD3 inhibitor that bridges the SAM-and MEKK2-binding pockets GS Van Aller, AP Graves, PA Elkins, WG Bonnette, PJ McDevitt, ... Structure 24 (5), 774-781, 2016 | 54 | 2016 |
| A high-throughput dose-response cellular thermal shift assay for rapid screening of drug target engagement in living cells, exemplified using SMYD3 and IDO1 DE McNulty, WG Bonnette, H Qi, L Wang, TF Ho, A Waszkiewicz, ... SLAS DISCOVERY: Advancing Life Sciences R&D 23 (1), 34-46, 2018 | 44 | 2018 |
| Pharmacologic Characterization of JNJ-42226314,[1-(4-Fluorophenyl) indol-5-yl]-[3-[4-(thiazole-2-carbonyl) piperazin-1-yl] azetidin-1-yl] methanone, a Reversible, Selective … RM Wyatt, I Fraser, N Welty, B Lord, M Wennerholm, S Sutton, ... Journal of Pharmacology and Experimental Therapeutics 372 (3), 339-353, 2020 | 23 | 2020 |
| Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1: NRF2) Protein … D Norton, WG Bonnette, JF Callahan, MG Carr, CM Griffiths-Jones, ... Journal of Medicinal Chemistry 64 (21), 15949-15972, 2021 | 16 | 2021 |
| Gut-restricted selective cyclooxygenase-2 (COX-2) inhibitors for chemoprevention of colorectal cancer Z Zhang, A Ghosh, PJ Connolly, P King, T Wilde, J Wang, Y Dong, X Li, ... Journal of Medicinal Chemistry 64 (15), 11570-11596, 2021 | 16 | 2021 |
| Discovery of isoxazole amides as potent and selective SMYD3 inhibitors DS Su, J Qu, M Schulz, CW Blackledge, H Yu, J Zeng, J Burgess, A Reif, ... ACS Medicinal Chemistry Letters 11 (2), 133-140, 2019 | 9 | 2019 |
| Modular protein Ligation: A new paradigm as a Reagent platform for pre-clinical Drug Discovery R Matico, LM Szewczuk, B Pietrak, S Chen, E Dul, WG Bonnette, ... Scientific Reports 9 (1), 13078, 2019 | 2 | 2019 |
| Development of a high-content imaging assay for screening compound aggregation Y Jiang, A Hoffman, G Quinque, WG Bonnette, LM Szewczuk, MA Holbert, ... Analytical biochemistry 559, 30-33, 2018 | 1 | 2018 |
| Mechanism-based irreversible inhibitors of the lysine demethylase LSD1 NW Johnson, J Kasparec, MB Rouse, X Tian, DP Suarez, KC McNulty, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 246, 2013 | | 2013 |
| Full wwPDB X-ray Structure Validation Report i○ JP Leite, L Gales | | |
