| Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis T Heimburg, A Chakrabarti, J Lancelot, M Marek, J Melesina, AT Hauser, ... Journal of Medicinal Chemistry 59 (6), 2423-2435, 2016 | 132 | 2016 |
| Characterization of histone deacetylase 8 (HDAC8) selective inhibition reveals specific active site structural and functional determinants M Marek, TB Shaik, T Heimburg, A Chakrabarti, J Lancelot, ... Journal of medicinal chemistry 61 (22), 10000-10016, 2018 | 104 | 2018 |
| Synthesis and biological investigation of phenothiazine-based benzhydroxamic acids as selective histone deacetylase 6 inhibitors K Vögerl, N Ong, J Senger, D Herp, K Schmidtkunz, M Marek, M Müller, ... Journal of medicinal chemistry 62 (3), 1138-1166, 2019 | 93 | 2019 |
| Structure-based design and biological characterization of selective histone deacetylase 8 (HDAC8) inhibitors with anti-neuroblastoma activity T Heimburg, FR Kolbinger, P Zeyen, E Ghazy, D Herp, K Schmidtkunz, ... Journal of Medicinal Chemistry 60 (24), 10188-10204, 2017 | 75 | 2017 |
| Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies M Brindisi, J Senger, C Cavella, A Grillo, G Chemi, S Gemma, ... European Journal of Medicinal Chemistry 157, 127-138, 2018 | 48 | 2018 |
| A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing CV Simoben, D Robaa, A Chakrabarti, K Schmidtkunz, M Marek, ... Molecules 23 (3), 566, 2018 | 46 | 2018 |
| Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as SmHDAC8 Inhibitors for the Treatment of Schistosomiasis T Bayer, A Chakrabarti, J Lancelot, TB Shaik, K Hausmann, J Melesina, ... ChemMedChem 13 (15), 1517-1529, 2018 | 27 | 2018 |
| Structure‐Based Design, Synthesis, and Biological Evaluation of Triazole‐Based smHDAC8 Inhibitors DV Kalinin, SK Jana, M Pfafenrot, A Chakrabarti, J Melesina, TB Shaik, ... ChemMedChem 15 (7), 571-584, 2020 | 22 | 2020 |
| Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2 M Marek, E Ramos-Morales, GFA Picchi-Constante, T Bayer, C Norström, ... Cell Reports 37 (12), 110129, 2021 | 11 | 2021 |
| Synthesis, structure-activity relationships, cocrystallization and cellular characterization of novel smHDAC8 inhibitors for the treatment of schistosomiasis E Ghazy, T Heimburg, J Lancelot, P Zeyen, K Schmidtkunz, A Truhn, ... European Journal of Medicinal Chemistry 225, 113745, 2021 | 10 | 2021 |
| Large-Scale Overproduction and Purification of Recombinant Histone Deacetylase 8 (HDAC8) from the Human-Pathogenic Flatworm Schistosoma mansoni M Marek, TB Shaik, S Duclaud, RJ Pierce, C Romier Histone Deacetylases: Methods and Protocols, 109-118, 2016 | 3 | 2016 |
| Asymmetric dimerization in a transcription factor superfamily is promoted by allosteric interactions with DNA AKM Patel, P Vilela, TB Shaik, AG McEwen, I Hazemann, K Brillet, ... Nucleic Acids Research 51 (16), 8864-8879, 2023 | 2 | 2023 |
| Structural Biology of Epigenetic Targets: Exploiting Complexity M Marek, TB Shaik, C Romier Epigenetic Drug Discovery, 11-44, 2019 | 2 | 2019 |
| FINE TUNING SOLUBLE EXPRESSION OF A HEME PROTEIN IN ESCHERICHIA COLI USING LACTOSE AS AN INDUCER TB Shaik, B Pal Journal of Proteins & Proteomics 6 (3), 2015 | 2 | 2015 |
| Structural characterization of nitric oxide-bound soluble Guanylate Cyclase using resonance Raman spectroscopy B Pal, K Tanaka, S Takenaka, TB Shaik, T Kitagawa Journal of Porphyrins and Phthalocyanines 17 (03), 240-246, 2013 | 2 | 2013 |
| Front Cover: Structure‐Based Design, Synthesis, and Biological Evaluation of Triazole‐Based smHDAC8 Inhibitors (ChemMedChem 7/2020) DV Kalinin, SK Jana, M Pfafenrot, A Chakrabarti, J Melesina, TB Shaik, ... ChemMedChem 15 (7), 559-559, 2020 | 1 | 2020 |
| The Cohesin ATPase cycle is mediated by specific conformational dynamics and interface plasticity of SMC1A and SMC3 ATPase domains MV Gomes, P Landwerlin, ML Diebold-Durand, TB Shaik, A Durand, ... bioRxiv, 2022.06. 24.497451, 2022 | | 2022 |
| Specific conformational dynamics of the ATPase head domains and DNA exit gate mediate the Cohesin ATPase cycle P Landwerlin, M Diebold-Durand, T Shaik, E Troesch, C Weber, A Durand, ... | | 2022 |
| Front Cover: Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as SmHDAC8 Inhibitors for the Treatment of … T Bayer, A Chakrabarti, J Lancelot, TB Shaik, K Hausmann, J Melesina, ... ChemMedChem 13 (15), 1488-1488, 2018 | | 2018 |
| Biochemical, biophysical and structural study of histone deacetylase HDAC8 action mechanism and selective inhibition TB Shaik Université de Strasbourg, 2017 | | 2017 |
Manfred JungInstitute of Pharmaceutical Sciences, University of Freiburg; former University of Münster, OttawaVerified email at pharmazie.uni-freiburg.de
