Robert A Cherny
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Soluble pool of Aβ amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
CA McLean, RA Cherny, FW Fraser, SJ Fuller, MJ Smith, K Vbeyreuther, ...
Annals of neurology 46 (6), 860-866, 1999
Treatment with a copper-zinc chelator markedly and rapidly inhibits β-amyloid accumulation in Alzheimer's disease transgenic mice
RA Cherny, CS Atwood, ME Xilinas, DN Gray, WD Jones, CA McLean, ...
Neuron 30 (3), 665-676, 2001
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Aβ amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial
CW Ritchie, AI Bush, A Mackinnon, S Macfarlane, M Mastwyk, ...
Archives of neurology 60 (12), 1685-1691, 2003
Alzheimer's disease amyloid-β binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits
CC Curtain, F Ali, I Volitakis, RA Cherny, RS Norton, K Beyreuther, ...
Journal of Biological Chemistry 276 (23), 20466-20473, 2001
Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Aβ
PA Adlard, RA Cherny, DI Finkelstein, E Gautier, E Robb, M Cortes, ...
Neuron 59 (1), 43-55, 2008
Metalloenzyme-like activity of Alzheimer's disease β-amyloid: Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H2O2
C Opazo, X Huang, RA Cherny, RD Moir, AE Roher, AR White, R Cappai, ...
Journal of Biological Chemistry 277 (43), 40302-40308, 2002
Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease
D Kaur, F Yantiri, S Rajagopalan, J Kumar, JQ Mo, R Boonplueang, ...
Neuron 37 (6), 899-909, 2003
Aqueous dissolution of Alzheimer's disease Aβ amyloid deposits by biometal depletion
RA Cherny, JT Legg, CA McLean, DP Fairlie, X Huang, CS Atwood, ...
Journal of Biological Chemistry 274 (33), 23223-23228, 1999
Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export
P Lei, S Ayton, DI Finkelstein, L Spoerri, GD Ciccotosto, DK Wright, ...
Nature medicine 18 (2), 291-295, 2012
Cytosolic β-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease
LE Goldstein, JA Muffat, RA Cherny, RD Moir, MH Ericsson, X Huang, ...
The Lancet 361 (9365), 1258-1265, 2003
Copper in the brain and Alzheimer’s disease
YH Hung, AI Bush, RA Cherny
JBIC Journal of Biological Inorganic Chemistry 15, 61-76, 2010
Overexpression of Alzheimer's disease amyloid-β opposes the age-dependent elevations of brain copper and iron
CJ Maynard, R Cappai, I Volitakis, RA Cherny, AR White, K Beyreuther, ...
Journal of Biological Chemistry 277 (47), 44670-44676, 2002
Mitochondrial oxidative stress causes hyperphosphorylation of tau
S Melov, PA Adlard, K Morten, F Johnson, TR Golden, D Hinerfeld, ...
PloS one 2 (6), e536, 2007
Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-β1-42
PJ Crouch, R Blake, JA Duce, GD Ciccotosto, QX Li, KJ Barnham, ...
Journal of Neuroscience 25 (3), 672-679, 2005
Hypoxia-inducible factor prolyl 4-hydroxylase inhibition: a target for neuroprotection in the central nervous system
A Siddiq, IA Ayoub, JC Chavez, L Aminova, S Shah, JC LaManna, ...
Journal of Biological Chemistry 280 (50), 41732-41743, 2005
Degradation of the Alzheimer disease amyloid β-peptide by metal-dependent up-regulation of metalloprotease activity
AR White, T Du, KM Laughton, I Volitakis, RA Sharples, ME Xilinas, ...
Journal of Biological Chemistry 281 (26), 17670-17680, 2006
Dopamine promotes α‐synuclein aggregation into SDS‐resistant soluble oligomers via a distinct folding pathway
R Cappai, SL Leck, DJ Tew, NA Williamson, DP Smith, D Galatis, ...
The FASEB journal 19 (10), 1377-1379, 2005
Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106− 126
MF Jobling, X Huang, LR Stewart, KJ Barnham, C Curtain, I Volitakis, ...
Biochemistry 40 (27), 8073-8084, 2001
Elevated cortical zinc in Alzheimer disease
D Religa, D Strozyk, RA Cherny, I Volitakis, V Haroutunian, B Winblad, ...
Neurology 67 (1), 69-75, 2006
Increasing Cu bioavailability inhibits Aβ oligomers and tau phosphorylation
PJ Crouch, LW Hung, PA Adlard, M Cortes, V Lal, G Filiz, KA Perez, ...
Proceedings of the National Academy of Sciences 106 (2), 381-386, 2009
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