Rational design and synthesis of highly potent pharmacological chaperones for treatment of N370S mutant Gaucher disease GN Wang, G Reinkensmeier, SW Zhang, J Zhou, LR Zhang, LH Zhang, ... Journal of medicinal chemistry 52 (10), 3146-3149, 2009 | 85 | 2009 |
Cocrystals of nicotinamide and (R)-mandelic acid in many ratios with anomalous formation properties SW Zhang, MT Harasimowicz, MM de Villiers, L Yu Journal of the American Chemical Society 135 (50), 18981-18989, 2013 | 73 | 2013 |
Celecoxib–nicotinamide cocrystal revisited: can entropy control cocrystal formation? SW Zhang, APJ Brunskill, E Schwartz, S Sun Crystal Growth & Design 17 (5), 2836-2843, 2017 | 50 | 2017 |
Covalent complexes of proteasome model with peptide aldehyde inhibitors MG132 and MG101: docking and molecular dynamics study S Zhang, Y Shi, H Jin, Z Liu, L Zhang, L Zhang Journal of molecular modeling 15 (12), 1481-1490, 2009 | 42 | 2009 |
Hot-stage optical microscopy as an analytical tool to understand solid-state changes in pharmaceutical materials N Stieger, M Aucamp, SW Zhang, MM De Villiers Am. Pharm. Rev 15, 32-36, 2012 | 36 | 2012 |
Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 1: Introduction and Process Overview H Ren, KM Maloney, K Basu, MJ Di Maso, GR Humphrey, F Peng, ... Organic Process Research & Development 24 (11), 2445-2452, 2020 | 29 | 2020 |
Formation enthalpies and polymorphs of nicotinamide–R-mandelic acid co-crystals SW Zhang, IA Guzei, MM de Villiers, L Yu, JF Krzyzaniak Crystal Growth & Design 12 (8), 4090-4097, 2012 | 28 | 2012 |
Synthesis of N-substituted ε-hexonolactams as pharmacological chaperones for the treatment of N370S mutant Gaucher disease GN Wang, G Twigg, TD Butters, S Zhang, L Zhang, LH Zhang, XS Ye Organic & biomolecular chemistry 10 (15), 2923-2927, 2012 | 27 | 2012 |
Building a better particle: Leveraging physicochemical understanding of amorphous solid dispersions and a hierarchical particle approach for improved delivery at high drug loadings L Schenck, AKP Mann, Z Liu, M Milewski, S Zhang, J Ren, K Dewitt, ... International journal of pharmaceutics 559, 147-155, 2019 | 23 | 2019 |
Synthesis and biological evaluation of novel 2-arylalkylthio-4-amino-6-benzyl pyrimidines as potent HIV-1 non-nucleoside reverse transcriptase inhibitors H Qin, C Liu, J Zhang, Y Guo, S Zhang, Z Zhang, X Wang, L Zhang, J Liu Bioorganic & medicinal chemistry letters 20 (9), 3003-3005, 2010 | 20 | 2010 |
A Method to Evaluate the Effect of Contact with Excipients on the Surface Crystallization of Amorphous Drugs SW Zhang, L Yu, J Huang, MA Hussain, L Derdour, F Qian, MM de Villiers AAPS PharmSciTech 15 (6), 1516-1526, 2014 | 19 | 2014 |
Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 2: Development of a Robust Process for Phenol Synthesis F Peng, GR Humphrey, KM Maloney, D Lehnherr, M Weisel, F Lévesque, ... Organic Process Research & Development 24 (11), 2453-2461, 2020 | 18 | 2020 |
Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264). Part 5: Completion of the API Free Base via a Direct Chlorosulfonylation Process MJ Di Maso, H Ren, SW Zhang, W Liu, R Desmond, E Alwedi, ... Organic Process Research & Development 24 (11), 2491-2497, 2020 | 12 | 2020 |
Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 3: Development of a One-Pot Formylation–Cyclization Sequence to the … K Basu, D Lehnherr, GE Martin, RA Desmond, Y Lam, F Peng, JYL Chung, ... Organic Process Research & Development 24 (11), 2462-2477, 2020 | 11 | 2020 |
Co‐crystallization with Nicotinamide in Two Conformations Lowers Energy but Expands Volume SW Zhang, J Kendrick, FJJ Leusen, L Yu Journal of pharmaceutical sciences 103 (9), 2896-2903, 2014 | 11 | 2014 |
Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264). Part 6: Development of an Improved Commercial Salt Formation Process KM Maloney, SW Zhang, AE Mohan, AY Lee, P Larpent, H Ren, ... Organic Process Research & Development 24 (11), 2498-2504, 2020 | 6 | 2020 |
Iterative Non-Negative Matrix Factorization Filter for Blind Deconvolution in Photon/Ion Counting SR Griffin, JA Biechele-Speziale, CJ Smith, X You-Dow, JK White, ... Analytical chemistry 91 (8), 5286-5294, 2019 | 4 | 2019 |
Triboluminescence from Pharmaceutical Formulations CJ Smith, SR Griffin, GS Eakins, F Deng, JK White, S Thirunahari, ... Analytical chemistry 90 (11), 6893-6898, 2018 | 3 | 2018 |
Solid‐State Properties SW Zhang, RF Dunn, AY Lee Early Drug Development: Bringing a Preclinical Candidate to the Clinic 1 …, 2018 | | 2018 |
Anomalous Formation Properties of Nicotinamide Co-crystals SW Zhang, L Yu Advances in Organic Crystal Chemistry, 337-353, 2015 | | 2015 |