| A general alkyl-alkyl cross-coupling enabled by redox-active esters and alkylzinc reagents T Qin, J Cornella, C Li, LR Malins, JT Edwards, S Kawamura, BD Maxwell, ... Science 352 (6287), 801-805, 2016 | 643 | 2016 |
| Practical Ni-catalyzed aryl–alkyl cross-coupling of secondary redox-active esters J Cornella, JT Edwards, T Qin, S Kawamura, J Wang, CM Pan, ... Journal of the American Chemical Society 138 (7), 2174-2177, 2016 | 437 | 2016 |
| Nineteen-step total synthesis of (+)-phorbol S Kawamura, H Chu, J Felding, PS Baran Nature 532 (7597), 90-93, 2016 | 211 | 2016 |
| Simple Sulfinate Synthesis Enables C H Trifluoromethylcyclopropanation R Gianatassio, S Kawamura, CL Eprile, K Foo, J Ge, AC Burns, ... Angewandte Chemie 126 (37), 10009-10013, 2014 | 156 | 2014 |
| Potent Proteasome Inhibitors Derived from the Unnatural cis-Cyclopropane Isomer of Belactosin A: Synthesis, Biological Activity, and Mode of Action S Kawamura, Y Unno, A List, A Mizuno, M Tanaka, T Sasaki, M Arisawa, ... Journal of medicinal chemistry 56 (9), 3689-3700, 2013 | 55 | 2013 |
| Cyclopropane-based conformational restriction of GABA by a stereochemical diversity-oriented strategy: Identification of an efficient lead for potent inhibitors of GABA transports K Nakada, M Yoshikawa, S Ide, A Suemasa, S Kawamura, T Kobayashi, ... Bioorganic & medicinal chemistry 21 (17), 4938-4950, 2013 | 44 | 2013 |
| Synthesis and pharmacological evaluation of nucleoside prodrugs designed to target siderophore biosynthesis in Mycobacterium tuberculosis S Dawadi, S Kawamura, A Rubenstein, R Remmel, CC Aldrich Bioorganic & medicinal chemistry 24 (6), 1314-1321, 2016 | 36 | 2016 |
| Allosteric modulation of protein arginine methyltransferase 5 (PRMT5) RL Palte, SE Schneider, MD Altman, RP Hayes, S Kawamura, BM Lacey, ... ACS Medicinal Chemistry Letters 11 (9), 1688-1693, 2020 | 34 | 2020 |
| Discovery of diaminopyrimidine carboxamide HPK1 inhibitors as preclinical immunotherapy tool compounds BA Vara, SM Levi, A Achab, DA Candito, X Fradera, CA Lesburg, ... ACS Medicinal Chemistry Letters 12 (4), 653-661, 2021 | 27 | 2021 |
| Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates S Kawamura, Y Unno, A Asai, M Arisawa, S Shuto Journal of medicinal chemistry 57 (6), 2726-2735, 2014 | 27 | 2014 |
| Investigation of the noncovalent binding mode of covalent proteasome inhibitors around the transition state by combined use of cyclopropylic strain-based conformational … S Kawamura, Y Unno, M Tanaka, T Sasaki, A Yamano, T Hirokawa, ... Journal of Medicinal Chemistry 56 (14), 5829-5842, 2013 | 27 | 2013 |
| Identification of potent reverse indazole inhibitors for HPK1 EC Yu, JL Methot, X Fradera, CA Lesburg, BM Lacey, P Siliphaivanh, ... ACS Medicinal Chemistry Letters 12 (3), 459-466, 2021 | 23 | 2021 |
| Rational hopping of a peptidic scaffold into non-peptidic scaffolds: structurally novel potent proteasome inhibitors derived from a natural product, belactosin A S Kawamura, Y Unno, T Hirokawa, A Asai, M Arisawa, S Shuto Chemical communications 50 (19), 2445-2447, 2014 | 23 | 2014 |
| Isolation and structure characterization of cytotoxic phorbol esters from the seeds of Croton tiglium Q Du, Y Zhao, H Liu, C Tang, M Zhang, C Ke, Y Ye Planta medica 83 (17), 1361-1367, 2017 | 22 | 2017 |
| Design and synthesis of the stabilized analogs of belactosin A with the unnatural cis-cyclopropane structure S Kawamura, Y Unno, A Asai, M Arisawa, S Shuto Organic & biomolecular chemistry 11 (38), 6615-6622, 2013 | 21 | 2013 |
| The discovery of two novel classes of 5, 5-bicyclic nucleoside-derived prmt5 inhibitors for the treatment of cancer RV Quiroz, MH Reutershan, SE Schneider, D Sloman, BM Lacey, ... Journal of Medicinal Chemistry 64 (7), 3911-3939, 2021 | 18 | 2021 |
| Asymmetric Reductive Dicarbofunctionalization of Alkenes via Nickel Catalysis D Anthony, T Diao Synlett 31 (15), 1443-1447, 2020 | 12 | 2020 |
| Development of a new class of proteasome inhibitors with an epoxyketone warhead: rational hybridization of non-peptidic belactosin derivatives and peptide epoxyketones S Kawamura, Y Unno, A Asai, M Arisawa, S Shuto Bioorganic & Medicinal Chemistry 22 (12), 3091-3095, 2014 | 9 | 2014 |
| Design and synthesis of unprecedented 9-and 10-membered cyclonucleosides with PRMT5 inhibitory activity S Kawamura, RL Palte, HY Kim, J Saurí, C Sondey, MS Mansueto, ... Bioorganic & Medicinal Chemistry 66, 116820, 2022 | 5 | 2022 |
| Ligand–Phospholipid Conjugation: A Versatile Strategy for Developing Long-Acting Ligands That Bind to Membrane Proteins by Restricting the Subcellular Localization of the Ligand S Kawamura, Y Ito, T Hirokawa, E Hikiyama, S Yamada, S Shuto Journal of Medicinal Chemistry 61 (9), 4020-4029, 2018 | 3 | 2018 |
