| Directed dihydroxylation of cyclic allylic alcohols and trichloroacetamides using OsO4/TMEDA TJ Donohoe, K Blades, PR Moore, MJ Waring, JJG Winter, M Helliwell, ... The Journal of organic chemistry 67 (23), 7946-7956, 2002 | 195 | 2002 |
| Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation RA Ward, C Brassington, AL Breeze, A Caputo, S Critchlow, G Davies, ... Journal of medicinal chemistry 55 (7), 3285-3306, 2012 | 183 | 2012 |
| Small molecule binding sites on the Ras: SOS complex can be exploited for inhibition of Ras activation JJG Winter, M Anderson, K Blades, C Brassington, AL Breeze, C Chresta, ... Journal of medicinal chemistry 58 (5), 2265-2274, 2015 | 133 | 2015 |
| Structure-based design of potent and selective inhibitors of the metabolic kinase PFKFB3 S Boyd, JL Brookfield, SE Critchlow, IA Cumming, NJ Curtis, J Debreczeni, ... Journal of medicinal chemistry 58 (8), 3611-3625, 2015 | 92 | 2015 |
| Directed dihydroxylation of allylic trichloroacetamides T Donohoe, K Blades, M Helliwell, P Moore, J Winter, G Stemp Journal of organic chemistry 64 (9), 1999 | 63 | 1999 |
| Hydrogen bonding control in the oxidative cyclisation of 1, 5-dienes TJ Donohoe, JJG Winter, M Helliwell, G Stemp Tetrahedron Letters 42 (6), 971-974, 2001 | 59 | 2001 |
| Discovery of (2R)-N-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent … Q Su, E Banks, G Bebernitz, K Bell, CF Borenstein, H Chen, CE Chuaqui, ... Journal of medicinal chemistry 63 (9), 4517-4527, 2020 | 41 | 2020 |
| A syn selective dihydroxylation of cyclic allylic trichloroacetamides using catalytic osmium tetroxide K Blades, TJ Donohoe, JJG Winter, G Stemp Tetrahedron Letters 41 (24), 4701-4704, 2000 | 34 | 2000 |
| MTH1 substrate recognition—an example of specific promiscuity JWM Nissink, M Bista, J Breed, N Carter, K Embrey, J Read, ... PLoS One 11 (3), e0151154, 2016 | 33 | 2016 |
| Potent, selective small molecule inhibitors of type III phosphatidylinositol-4-kinase α-but not β-inhibit the phosphatidylinositol signaling cascade and cancer cell proliferation MJ Waring, DM Andrews, PF Faulder, V Flemington, JC McKelvie, ... Chemical communications 50 (40), 5388-5390, 2014 | 33 | 2014 |
| Modulators of the human CCR5 receptor. Part 2: SAR of substituted 1-(3, 3-diphenylpropyl)-piperidinyl phenylacetamides JG Cumming, AE Cooper, K Grime, CJ Logan, S McLaughlin, J Oldfield, ... Bioorganic & medicinal chemistry letters 15 (22), 5012-5015, 2005 | 32 | 2005 |
| Thienopyrimidines and Thiazolopyrimidines for Use in Medicine J Bower, A Faull, J Winter US Patent App. 11/628,449, 2007 | 30 | 2007 |
| Discovery of a thiadiazole–pyridazine-based allosteric glutaminase 1 inhibitor series that demonstrates oral bioavailability and activity in tumor xenograft models MRV Finlay, M Anderton, A Bailey, S Boyd, J Brookfield, C Cairnduff, ... Journal of Medicinal Chemistry 62 (14), 6540-6560, 2019 | 22 | 2019 |
| Exploiting structural information in patent specifications for key compound prediction C Tyrchan, J Boström, F Giordanetto, J Winter, S Muresan Journal of chemical information and modeling 52 (6), 1480-1489, 2012 | 22 | 2012 |
| The structure of human GCN2 reveals a parallel, back-to-back kinase dimer with a plastic DFG activation loop motif T Maia de Oliveira, V Korboukh, S Caswell, JJ Winter Holt, M Lamb, ... Biochemical Journal 477 (1), 275-284, 2020 | 20 | 2020 |
| The design and synthesis of novel, potent and orally bioavailable N-aryl piperazine-1-carboxamide CCR2 antagonists with very high hERG selectivity JG Cumming, JF Bower, D Waterson, A Faull, PJ Poyser, P Turner, ... Bioorganic & medicinal chemistry letters 22 (12), 3895-3899, 2012 | 20 | 2012 |
| Discovery of a potent and selective ATAD2 bromodomain inhibitor with antiproliferative activity in breast cancer models JJ Winter-Holt, C Bardelle, E Chiarparin, IL Dale, PRJ Davey, NL Davies, ... Journal of Medicinal Chemistry 65 (4), 3306-3331, 2022 | 17 | 2022 |
| Optimization of an Imidazo[1,2-a]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy W McCoull, S Boyd, MR Brown, M Coen, O Collingwood, NL Davies, ... Journal of Medicinal Chemistry 64 (18), 13524-13539, 2021 | 17 | 2021 |
| A system for encoding and searching Markush structures DA Cosgrove, KM Green, AG Leach, A Poirrette, J Winter Journal of chemical information and modeling 52 (8), 1936-1947, 2012 | 17 | 2012 |
| Pyridine and pyrazine derivatives-083 BC Barlaam, CS Harris, CMP Lambert, G Ouvry, JF Bower, B Delouvrie, ... US Patent 8,017,611, 2011 | 16 | 2011 |
Jason Grant KettlePrincipal Scientist, Medicinal Chemistry, Oncology iMED, AstraZenecaVerified email at astrazeneca.com
