Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine W Tai, L He, X Zhang, J Pu, D Voronin, S Jiang, Y Zhou, L Du Cellular & molecular immunology 17 (6), 613-620, 2020 | 1885 | 2020 |
The antihistamine drugs carbinoxamine maleate and chlorpheniramine maleate exhibit potent antiviral activity against a broad spectrum of influenza viruses W Xu, S Xia, J Pu, Q Wang, P Li, L Lu, S Jiang Frontiers in microbiology 9, 411040, 2018 | 46 | 2018 |
Development of protein-and peptide-based HIV entry inhibitors targeting gp120 or gp41 J Pu, Q Wang, W Xu, L Lu, S Jiang Viruses 11 (8), 705, 2019 | 44 | 2019 |
Potent MERS-CoV fusion inhibitory peptides identified from HR2 domain in spike protein of bat coronavirus HKU4 S Xia, Q Lan, J Pu, C Wang, Z Liu, W Xu, Q Wang, H Liu, S Jiang, L Lu Viruses 11 (1), 56, 2019 | 32 | 2019 |
A highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases J Zhou, W Xu, Z Liu, C Wang, S Xia, Q Lan, Y Cai, S Su, J Pu, L Xing, ... Acta Pharmaceutica Sinica B 12 (4), 1652-1661, 2022 | 28 | 2022 |
A five-helix-based SARS-CoV-2 fusion inhibitor targeting heptad repeat 2 domain against SARS-CoV-2 and its variants of concern L Xing, X Xu, W Xu, Z Liu, X Shen, J Zhou, L Xu, J Pu, C Yang, Y Huang, ... Viruses 14 (3), 597, 2022 | 27 | 2022 |
Design and Biological Evaluation of m-Xylene Thioether-Stapled Short Helical Peptides Targeting the HIV-1 gp41 Hexameric Coiled–Coil Fusion Complex G Meng, J Pu, Y Li, A Han, Y Tian, W Xu, T Zhang, X Li, L Lu, C Wang, ... Journal of medicinal chemistry 62 (19), 8773-8783, 2019 | 19 | 2019 |
Revisiting the mechanism of enfuvirtide and designing an analog with improved fusion inhibitory activity by targeting triple sites in gp41 W Xu, J Pu, S Su, C Hua, X Su, Q Wang, S Jiang, L Lu AIDS 33 (10), 1545-1555, 2019 | 19 | 2019 |
A palmitic acid-conjugated, peptide-based pan-CoV fusion inhibitor potently inhibits infection of SARS-CoV-2 Omicron and other variants of concern Q Lan, JFW Chan, W Xu, L Wang, F Jiao, G Zhang, J Pu, J Zhou, S Xia, ... Viruses 14 (3), 549, 2022 | 13 | 2022 |
The analogs of furanyl methylidene rhodanine exhibit broad-spectrum inhibitory and inactivating activities against enveloped viruses, including SARS-CoV-2 and its variants J Pu, X He, W Xu, C Wang, Q Lan, C Hua, K Wang, L Lu, S Jiang Viruses 14 (3), 489, 2022 | 13 | 2022 |
A “two-birds-one-stone” approach toward the design of bifunctional human immunodeficiency virus type 1 entry inhibitors targeting the CCR5 coreceptor and gp41 N-terminal heptad … C Wang, X Wang, H Wang, J Pu, Q Li, J Li, Y Liu, L Lu, S Jiang Journal of Medicinal Chemistry 64 (15), 11460-11471, 2021 | 13 | 2021 |
An amphipathic peptide targeting the gp41 cytoplasmic tail kills HIV-1 virions and infected cells Q Wang, S Su, J Xue, F Yu, J Pu, W Bi, S Xia, Y Meng, C Wang, W Yang, ... Science Translational Medicine 12 (546), eaaz2254, 2020 | 9 | 2020 |
Viral entry inhibitors targeting six-helical bundle core against highly pathogenic enveloped viruses with class I fusion proteins J Pu, JT Zhou, P Liu, F Yu, X He, L Lu, S Jiang Current Medicinal Chemistry 29 (4), 700-718, 2022 | 8 | 2022 |
Rational design of a novel small-molecule HIV-1 inactivator targeting both gp120 and gp41 of HIV-1 J Pu, Y Dai, Q Wang, L Lu, J Zhang, W Xu, L Xie, S Wang, F Yu, X He, ... Frontiers in Pharmacology 11, 613361, 2021 | 7 | 2021 |
Lipopeptide-based pan-CoV fusion inhibitors potently inhibit HIV-1 infection Q Lan, J Pu, Y Cai, J Zhou, L Wang, F Jiao, W Xu, Q Wang, S Xia, L Lu, ... Microbes and Infection 23 (8), 104840, 2021 | 2 | 2021 |
An inducible hACE2 transgenic mouse model recapitulates SARS-CoV-2 infection and pathogenesis in vivo K Liu, M Tang, W Xu, X Meng, H Jin, M Han, J Pu, Y Li, F Jiao, R Sun, ... Proceedings of the National Academy of Sciences 120 (25), e2207210120, 2023 | 1 | 2023 |
A dePEGylated Lipopeptide-Based Pan-Coronavirus Fusion Inhibitor Exhibits Potent and Broad-Spectrum Anti-HIV-1 Activity without Eliciting Anti-PEG Antibodies L Xu, C Wang, W Xu, L Xing, J Zhou, J Pu, M Fu, L Lu, S Jiang, Q Wang International Journal of Molecular Sciences 24 (11), 9779, 2023 | | 2023 |
Peptide-Based HIV Entry Inhibitors J Pu, Q Wang, S Jiang Virus Entry Inhibitors: Stopping the Enemy at the Gate, 15-26, 2022 | | 2022 |
P848 Revisiting enfuvirtide’s mechanism and designing its analog with improved activity by targeting triple sites in gp41 S Jiang, W Xu, J Pu, S Su, C Hua, X Su, Q Wang, L Lu Sexually Transmitted Infections 95 (Suppl 1), A355-A356, 2019 | | 2019 |