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Megan Agajanian
Megan Agajanian
Unknown affiliation
Verified email at email.unc.edu
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Cited by
Year
The whole-genome landscape of Burkitt lymphoma subtypes
RI Panea, CL Love, JR Shingleton, A Reddy, JA Bailey, AM Moormann, ...
Blood, The Journal of the American Society of Hematology 134 (19), 1598-1607, 2019
1392019
Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell
M Puray-Chavez, KM LaPak, TP Schrank, JL Elliott, DP Bhatt, ...
Cell Reports 36 (2), 2021
1312021
WNT activates the AAK1 kinase to promote clathrin-mediated endocytosis of LRP6 and establish a negative feedback loop
MJ Agajanian, MP Walker, AD Axtman, RR Ruela-de-Sousa, DS Serafin, ...
Cell reports 26 (1), 79-93. e8, 2019
752019
PEAK1 acts as a molecular switch to regulate context-dependent TGFβ responses in breast cancer
M Agajanian, A Campeau, M Hoover, A Hou, D Brambilla, SL Kim, ...
PLoS One 10 (8), e0135748, 2015
522015
Identification of a PEAK1/ZEB1 signaling axis during TGFβ/fibronectin-induced EMT in breast cancer
M Agajanian, F Runa, JA Kelber
Biochemical and biophysical research communications 465 (3), 606-612, 2015
472015
Gain-of-function genetic screen of the kinome reveals BRSK2 as an inhibitor of the NRF2 transcription factor
TY Tamir, BM Bowman, MJ Agajanian, D Goldfarb, TP Schrank, T Stohrer, ...
Journal of cell science 133 (14), jcs241356, 2020
222020
A SNAI2-PEAK1-INHBA stromal axis drives progression and lapatinib resistance in HER2-positive breast cancer by supporting subpopulations of tumor cells positive for …
S Hamalian, R Güth, F Runa, F Sanchez, E Vickers, M Agajanian, ...
Oncogene 40 (33), 5224-5235, 2021
132021
Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell. Cell Rep 36: 109364
M Puray-Chavez, KM LaPak, TP Schrank, JL Elliott, DP Bhatt, ...
122021
Protein proximity networks and functional evaluation of the casein kinase 1 gamma family reveal unique roles for CK1γ3 in WNT signaling
MJ Agajanian, FM Potjewyd, BM Bowman, S Solomon, KM LaPak, ...
Journal of Biological Chemistry 298 (6), 2022
62022
DHPS-dependent hypusination of eIF5A1/2 is necessary for TGFβ/fibronectin-induced breast cancer metastasis and associates with prognostically unfavorable genomic alterations in …
R Güth, Y Adamian, C Geller, J Molnar, J Maddela, L Kutscher, K Bhakta, ...
Biochemical and biophysical research communications 519 (4), 838-845, 2019
62019
Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell (preprint)
M Puray-Chavez, KM Lapak, TP Schrank, JL Elliott, DP Bhatt, ...
2021
Kinase Regulation of WNT Signaling
MJ Agajanian
The University of North Carolina at Chapel Hill, 2021
2021
A SNAI2-PEAK1 stromal axis drives progression and lapatinib resistance in HER2-positive breast cancer by supporting a cytokine expression profile that converges on PI3K/Akt …
S Hamalian, R Güth, F Runa, J Molnar, E Vickers, M Agajanian, ...
bioRxiv, 2020.05. 15.098772, 2020
2020
Mesenchymal stromal cells expressing a PEAK1/Cripto axis sustain pro-survival NF-κB signaling in adjacent tumor cells to promote disease progression and therapy resistance
S Hamalian, R Güth, I Zervantonakis, E Duell, JR Lin, P Shisgal, J Molnar, ...
Cancer Research 78 (13_Supplement), 2140-2140, 2018
2018
AAK1 inhibits WNT signaling by promoting clathrin-mediated endocytosis of LRP6
MJ Agajanian, MP Walker, AD Axtman, RR Ruela-de-Sousa, ...
bioRxiv, 258632, 2018
2018
A Transcription-uncoupled Negative Feedback Loop for the 1 WNT Pathway: WNT Activates the AAK1 Kinase to Promote Clathrin-mediated Endocytosis of LRP6
MJ Agajanian, MP Walker, AD Axtman, RR Ruela-de-Sousa, ...
2018
The PEAK1/ZEB1/ITGA1 pathway mediates survival, stemness and TGFbeta-induced EMT in pancreatic cancer
A Gharibi, SL Kim, D Brambilla, Y Adamian, M Hoover, J Lin, M Agajanian, ...
Cancer Research 76 (14_Supplement), 4426-4426, 2016
2016
ITGA1 is a novel biomarker and therapeutic target for blocking stemness in pancreatic cancer.
S Kim, A Gharibi, DC Brambilla, Y Adamian, M Hoover, J Lin, M Agajanian, ...
MOLECULAR BIOLOGY OF THE CELL 27, 2016
2016
Identification of a PEAK1/ZEB1 signaling axis during TGFβ/fibronectin-induced EMT in breast cancer
M Agajanian, JA Kelberauthor
2015
PEAK1 kinase acts as a molecular switch to mediate TGFbeta-induced EMT in breast cancer
M Agajanian, A Campeau, D Brambilla, M Hoover, R Klemke, J Kelber
MOLECULAR BIOLOGY OF THE CELL 25, 2014
2014
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